Tsutomu Akama

6452014, Sep 17, 2002

Dec 22, 2000

09/748622

Tsutomu Akama - Redwood City CA
Ryan Holcomb - San Carlos CA
Richard L. Tolman - Los Altos CA

Geron Corporation - Menlo Park CA

A01N 4378

546260, 514394, 548182, 548186, 548189

Thiazolidinedione compounds, compositions, and methods of inhibiting telomerase activity in vitro and treatment of telomerase mediated conditions or diseases ex vivo and in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of conditions or diseases mediated by telomerase activity, such as in the treatment of cancer. Also disclosed are methods for assaying or screening for inhibitors of telomerase activity.

6518268, Feb 11, 2003

Jun 30, 2000

09/608636

Allison C. Chin - Stanford CA
Ryan Holcomb - San Carlos CA
Mieczyslaw A. Piatyszek - Morgan Hill CA
Upinder Singh - Fremont CA
Richard L. Tolman - Los Altos CA
Tsutomu Akama - Redwood City CA
Yutaka Kanda - Tokyo, JP
Akira Asai - Sagamihara, JP
Yoshinori Yamashita - Tokyo, JP
Kaori Endo - Kamakura, JP
Hiroyuki Yamaguchi - Tokyo, JP

Geron Corporation - Menlo Park CA
Kyowa Hakko Kogyo Co., Ltd. - Tokyo

A61K 31535

5142368, 51425402, 514369, 514386, 544133, 544367, 548183

Thiazolidinedione compounds, compositions, and methods of inhibiting telomerase activity in vitro and treatment of telomerase mediated conditions or diseases ex vivo and in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of conditions or diseases mediated by telomerase activity, such as in the treatment of cancer. Also disclosed are novel methods for assaying or screening for inhibitors of telomerase activity.

6613774, Sep 2, 2003

Jan 2, 2001

09/720900

Tsutomu Akama - Redwood City CA
Hiroyuki Nagata - Shizuoka, JP
Atsuhiro Hasegawa - Tokyo, JP
Harumi Ue - Kanagawa, JP
Isami Takahashi - Tokyo, JP
Yutaka Saitoh - Shizuoka, JP
Kenichi Mochida - Kanagawa, JP
Shun-ichi Ikeda - Osaka, JP
Yutaka Kanda - Tokyo, JP

Kyowa Hakko Kogyo Co., Ltd. - Tokyo

A61K 314745

514292, 546 84

LK6-A derivatives which have immmunosuppressive activity, cell growth inhibitory activity, anti-tumor activity, etc. and which are represented by general formula (I): as defined herein, and pharmaceutically acceptable salts thereof.

6812246, Nov 2, 2004

Jun 12, 2003

10/240883

Kenneth M. Snader - Germantown MD
B. Rao Vishnuvajjala - Rockville MD
Tsutomu Akama - Sunnyvale CA

The United States of America as represented by the Department of Health and Human Services - Washington DC

A61K 3135

514456, 549403

The invention provides an aminoflavone having formula (I), wherein each of R and R is H, COCH âR , wherein R is amino alkylamino, dialkylamino, or alkyl- or dialkylaminoalkyl, or an -amino acid residue, provided that at least one of R or R is other than H, and R is H, branched or straight-chain alkyl, hydroxyalkyl, alkanoyloxyalkyl, alkanoyloxy, alkoxy, or alkoxyalkyl, or pharmaceutically acceptable salts thereof. The present invention also provides a pharmaceutical composition comprising an aminoflavone as described above, and a method of inhibiting the growth of a tumor in a host by administering a tumor growth-inhibiting amount of an aminoflavone compound having the formula as described above.

6815449, Nov 9, 2004

Nov 7, 2002

10/289317

Tsutomu Akama - Redwood City CA
Hiroyuki Nagata - Sunto-gun, JP
Atsuhiro Hasegawa - Machida, JP
Harumi Ue - Kawasaki, JP
Isami Takahashi - Tama, JP
Yutaka Saitoh - Numazu, JP
Kenichi Mochida - Hiratsuka, JP
Shun-ichi Ikeda - Sakai, JP
Yutaka Kanda - Machida, JP

Kyowa Hakko Kogyo Co., Ltd. - Tokyo

A61K 314745

514292, 51425303, 5142328, 546 84, 544126, 544361

Compounds having immunosuppressive activity, cell growth inhibitory activity, anti-tumor activity, etc. are represented by formula I: and pharmaceutically acceptable salts thereof.

6869971, Mar 22, 2005

Oct 19, 2000

10/110964

Tsutomu Akama - Sunnyvale CA, US
Akira Asai - San Diego CA, US
Tsutomu Agatsuma - Machida, JP
Shinji Nara - Sunto-gun, JP
Yoshinori Yamashita - Sunto-gun, JP
Tamio Mizukami - Chiyoda-Ku, JP
Shun-ichi Ikeda - Machida, JP
Yutaka Saitoh - Sunto-gun, JP
Yutaka Kanda - Sunto-gun, JP

Kyowa Hakko Kogyo Co., Ltd. - Tokyo

A61K031/403
A61K031/4453
C07D209/52
C07D401/06

514413, 514323, 548453, 546201

UCS 1025 derivatives having antitumor activity or antibacterial activity which are represented by formula (I): wherein Rrepresents hydrogen, lower alkyl, etc. ; Rrepresents hydrogen, or is combined with Rto represent a bond, etc. , or is combined with Rto represent —O(C═O)—, etc. ; Rrepresents hydrogen, etc. , or is combined with Rto represent a bond, etc. ; Rrepresents hydrogen, etc. , or is combined with Rto represent —(C═O)O—, etc. ; Rrepresents hydrogen or is combined with Rto represent a bond; Rrepresents hydrogen, etc. , or is combined with Rto represent a bond; Rrepresents hydrogen or is combined with Rto represent ═O; Rrepresents hydroxy or is combined with Rto represent ═O; represents a single bond or a double bond, and a represents a single bond (two carbon atoms to which a is bound are combined to form a single bond) or an oxygen atom, or pharmaceutically acceptable salts thereof.

7390806, Jun 24, 2008

Jun 14, 2004

10/867465

Ving Lee - Los Altos CA, US
Stephen J. Benkovic - State College PA, US
Stephen J. Baker - Mountain View CA, US
Kirk R. Maples - San Jose CA, US
Tsutomu Akama - Sunnyvale CA, US
Yong-Kang Zhang - San Jose CA, US
Rajeshwar Singh - Edmonton, CA
Vittorio A. Sauro - Edmonton, CA
Chetan Pandit - Edmonton, CA
Zhuoyi Su - Edmonton, CA
Zhixiang Yang - Edmonton, CA

Anacor Pharmaceuticals, Inc. - Palo Alto CA

C07D 484/04
C07D 215/02
C07D 215/20
C07D 239/70
C07D 253/08
A61K 31/47
A61P 31/04
A61P 31/10

514242, 514248, 544 69, 546 13

The structure and preparation of antibiotics incorporating borinic acid complexes are disclosed, especially hydroxyquinoline, imidazole and picolinic acid derivatives, along with compositions of these antibiotics and methods of using the antibiotics and compositions as bactericidal and fungicidal agents as well as therapeutic agents for the treatment of diseases caused by bacteria and fungi.

7465836, Dec 16, 2008

Jun 15, 2004

10/868268

Ving Lee - Los Altos CA, US
Jacob J. Plattner - Berkeley CA, US
Stephen J. Benkovic - State College PA, US
Stephen J. Baker - Mountain View CA, US
Kirk R. Maples - San Jose CA, US
Tsutomu Akama - Sunnyvale CA, US
Yong-Kang Zhang - San Jose CA, US
Rajeshwar Singh - Edmonton, CA
Vittorio A. Sauro - Edmonton, CA

Anacor Pharmaceuticals, Inc. - Palo Alto CA

C07F 9/02

568 8

Compositions and methods of use of borole derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.