Inventors:
Arthur D. Patten - Wilmington DE
Gregory Pacofsky - Wilmington DE
Steven P. Seitz - Swarthmore PA
Emeka A. Akamike - Bear DE
Robert J. Cherney - Newark DE
Robert F. Kaltenbach - Wilmington DE
Michael J. Orwat - Wilmington DE
Assignee:
The DuPont Merck Pharmaceutical Company - Wilmington DE
International Classification:
A61K 3147
Abstract:
Anticancer compounds of formula I: ##STR1## and pharmaceutically acceptable salts thereof, wherein: R. sup. 1, R. sup. 2, R. sup. 3, R. sup. 9 and R. sup. 10 are independently selected from the group H, C. sub. 1 -C. sub. 4 alkyl, OR. sup. 4, N(R. sup. 4). sub. 2, NO. sub. 2, CN, F, Cl, Br, I, Ph, and CF. sub. 3, and NHC(O)R. sup. 4 ; R. sup. 4 is independently selected from the group H, C. sub. 1 -C. sub. 4 alkyl, Ph, and CH. sub. 2 Ph; X. sup. 1 and Y. sup. 1, and X. sup. 2 and Y. sup. 2 when present, join together to form: a benzene ring substituted with 1-4 R. sup. 3 ; a five membered heterocycle having 1-2N, NH, O or S atoms and substituted with 1-2 R. sup. 3 ; a six membered heterocycle having 1-2N and substituted with 1-2 R. sup. 3 ; or the group: ##STR2## wherein one of W or Z is C. dbd.
