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Roger Paul Bakale

from Cardiff by the Sea, CA
Age ~65
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Also known as:
Roger P Bakale, Roger P Bakala
Phone and address:
2119 Via Tiempo, Cardiff By The Sea, CA 92007
Related to:
James A Walker, 88
Connected to:
Avigail Bakaleynik, 56Abdur R Bakali, 67Deborah E Bakalich, 68Fatima Bakali, 71Kyle H Bakalich, 32Salim A Bakali, 63Vahe S Bakalian, 46Dimitrios Bakalis, 36Gazmend P Bakalli, 62Michael L Bakalor, 69

Roger Bakale Phones & Addresses

  • 2119 Via Tiempo, Cardiff, CA 92007
  • Cardiff by the Sea, CA
  • San Diego, CA
  • 8 Devonshire Ln, Malvern, PA 19355 (610) 647-3536
  • 1212 Cornerstone Blvd, Downingtown, PA 19335 (610) 269-0142
  • 4 Comstock Dr, Shrewsbury, MA 01545 (508) 842-6364
  • North Brunswick, NJ
  • Chester, PA
  • Detroit, MI
  • 8 Devonshire Ln, Malvern, PA 19355 (508) 842-6364

Work

Company: Teva pharmaceuticals Nov 2011 to Dec 2014 Position: Senior director, chemical process r and d

Education

Degree: Doctorates, Doctor of Philosophy School / High School: Wayne State University 1983 to 1988 Specialities: Philosophy, Organic Chemistry

Skills

Pharmaceutical Industry • Technology Transfer • Gmp • R&D • Chemistry • Organic Chemistry • Drug Discovery • Validation • Biotechnology • Glp • Clinical Development • Analytical Chemistry • Sop • Pharmaceutics • Clinical Research • Medicinal Chemistry • Cro • Change Control • Research and Development • Pharmacology • Manufacturing • Process Simulation • Standard Operating Procedure

Interests

Civil Rights and Social Action • Education • Environment • Science and Technology • Disaster and Humanitarian Relief • Human Rights • Animal Welfare • Arts and Culture

Industries

Pharmaceuticals

Resumes

Resumes

Roger Bakale Photo 1

Vp, Cmc - Product Development And Mfg

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Location:
San Diego, CA
Industry:
Pharmaceuticals
Work:
Teva Pharmaceuticals Nov 2011 - Dec 2014
Senior Director, Chemical Process R and D
Celgene Nov 2011 - Dec 2014
Vp, Cmc - Product Development and Mfg
Cephalon Jul 2007 - Oct 2011
Senior Director Ww Chemical Process R and D
Sunovion Pharmaceuticals Inc. 1993 - 2007
Executive Director Cprd
Bristol-Myers Squibb 1988 - 1993
Senior Research Investgator Ii
Education:
Wayne State University 1983 - 1988
Doctorates, Doctor of Philosophy, Philosophy, Organic Chemistry Hope College 1977 - 1981
Skills:
Pharmaceutical Industry
Technology Transfer
Gmp
R&D
Chemistry
Organic Chemistry
Drug Discovery
Validation
Biotechnology
Glp
Clinical Development
Analytical Chemistry
Sop
Pharmaceutics
Clinical Research
Medicinal Chemistry
Cro
Change Control
Research and Development
Pharmacology
Manufacturing
Process Simulation
Standard Operating Procedure
Interests:
Civil Rights and Social Action
Education
Environment
Science and Technology
Disaster and Humanitarian Relief
Human Rights
Animal Welfare
Arts and Culture

Publications

Us Patents

Methods Of Treating Muscle Spasms Using N-Desmethylzopiclone

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US Patent:
6458791, Oct 1, 2002
Filed:
Jan 9, 2002
Appl. No.:
10/040475
Inventors:
Thomas P. Jerussi - Framingham MA
Chrisantha H. Senanayake - Shrewsbury MA
Paul D. Rubin - Sudbury MA
Yaping Hong - Framingham MA
Roger A. Bakale - Shrewsbury MA
Tingjian Xiang - Thousand Oaks MA
Fran A. McConville - Grafton MA
Assignee:
Sepracor, Inc. - Marlborough MA
International Classification:
A61K 31495
US Classification:
514249
Abstract:
The invention is directed to compositions comprising, and methods of using, racemic N-desmethylzopiclone, optically pure (+)-N-desmethylzopiclone, and optically pure (-)-N-desmethylzopiclone in the treatment and prevention of diseases and conditions in mammals. The invention is further directed to novel methods of preparing N-desmethylzopiclone, optically pure (+)-N-desmethylzopiclone, and optically pure (-)-N-desmethylzopiclone.

Methods Of Making And Using N-Desmethylzopiclone

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US Patent:
6506753, Jan 14, 2003
Filed:
Jun 11, 2001
Appl. No.:
09/877103
Inventors:
Thomas P. Jerussi - Framingham MA
Chrisantha H. Senanayake - Shrewsbury MA
Paul D. Rubin - Sudbury MA
Yaping Hong - Framingham MA
Roger A. Bakale - Shrewsbury MA
Tingjian Xiang - Thousand Oaks CA
Fran A. McConville - Grafton MA
Assignee:
Sepracor, Inc. - Marlborough MA
International Classification:
A61K 3150
US Classification:
514249
Abstract:
The invention is directed to compositions comprising, and methods of using, racemic N-desmethylzopiclone, optically pure (+)-N-desmethylzopiclone, and optically pure (-)-N-desmethylzopiclone in the treatment and prevention of diseases and conditions in mammals. The invention is further directed to novel methods of preparing N-desmethylzopiclone, optically pure (+)-N-desmethylzopiclone, and optically pure (-)-N-desmethylzopiclone.

Norastemizole Polymorphs

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US Patent:
6627646, Sep 30, 2003
Filed:
Jul 17, 2001
Appl. No.:
09/907556
Inventors:
Roger P. Bakale - Shrewsbury MA
Chris Senanayake - Shrewsbury MA
Yaping Hong - Princeton NJ
Kostas Saranteas - Peabody MA
Martin P. Redmon - Oxford MA
Stephen A. Wald - Sudbury MA
Assignee:
Sepracor Inc. - Marlborough MA
International Classification:
A61K 31445
US Classification:
514322, 514303, 514313, 546199
Abstract:
Polymorphic crystalline forms of the antihistaminic drug norasternizole are disclosed. Processes for the production of the preferred polymorph are also disclosed.

Method Of Resolving Amlodipine Racemate

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US Patent:
6822099, Nov 23, 2004
Filed:
Dec 20, 2002
Appl. No.:
10/325686
Inventors:
Chris H. Senanayake - Danbury CT
Gerald J. Tanoury - Hudson MA
Harold S. Wilkinson - Marlborough MA
Roger P. Bakale - Shrewsbury MA
Andrei A. Zlota - Sharon MA
Assignee:
Sepracor, Inc. - Marlborough MA
International Classification:
C07D21380
US Classification:
546355, 546321, 546319, 546356
Abstract:
The invention relates to methods of resolving racemic amlodipine into enantiomerically enriched compositions by precipitation with tartaric acid in the presence of a non-aqueous solvent, such as N,Nâ-dimethylacetamide. The molar ratio of tartaric acid:amlodipine is preferably less than 0. 25:1. 0 or greater than 0. 75:1.

Methods Of Treating And Preventing A Convulsive State

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US Patent:
6946464, Sep 20, 2005
Filed:
Jan 13, 2003
Appl. No.:
10/340957
Inventors:
Thomas P. Jerussi - Framingham MA, US
Chrisantha H. Senanayake - Shrewsbury MA, US
Paul D. Rubin - Sudbury MA, US
Yaping Hong - Framingham MA, US
Roger A. Bakale - Shrewsbury MA, US
Tingjian Xiang - Northboro MA, US
Fran A. McConville - Grafton MA, US
Assignee:
Sepracor Inc. - Marlborough MA
International Classification:
A61K031/50
A61K031/495
US Classification:
514249, 514250, 514 58
Abstract:
The invention is directed to compositions comprising, and methods of using, racemic N-desmethylzopiclone, optically pure (+)-N-desmethylzopiclone, and optically pure (−)-N-desmethylzopiclone in the treatment and prevention of diseases and conditions in mammals. The invention is further directed to novel methods of preparing N-desmethylzopiclone, optically pure (+)-N-desmethylzopiclone, and optically pure (−)-N-desmethylzopiclone.

Levalbuterol Salt

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US Patent:
7256310, Aug 14, 2007
Filed:
Dec 8, 2003
Appl. No.:
10/728873
Inventors:
Paul McGlynn - Marlborough MA, US
Roger Bakale - Shrewsbury MA, US
Craig Sturge - Falmouth, CA
Assignee:
Sepracor Inc. - Marlborough MA
International Classification:
C07C 215/00
C07C 205/00
US Classification:
564355, 568706
Abstract:
Levalbuterol L-tartrate affords crystals possessing properties desirable for use in a metered dose inhaler.

Preparation Of Chiral Amides And Amines

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US Patent:
8097760, Jan 17, 2012
Filed:
Mar 30, 2007
Appl. No.:
12/281819
Inventors:
Hang Zhao - Westborough MA, US
Stefan G. Koenig - Shrewsbury MA, US
Charles P. Vandenbossche - Waltham MA, US
Surendra Singh - Shrewsbury MA, US
Harold Scott Wilkinson - Westborough MA, US
Roger P. Bakale - Malvern PA, US
Assignee:
Sunovion Pharmacuticals Inc. - Marlborough MA
International Classification:
C07C 321/00
C07C 323/00
C07C 381/00
C07C 211/00
US Classification:
564192, 564307
Abstract:
This invention provides a convenient method for converting oximes into enamides. The process does not require the use of metallic reagents. Accordingly, it produces the desired compounds without the concomitant production of a large volume of metallic waste. The enamides are useful precursors to amides and amines. The invention provides a process to convert a prochiral enamide into the corresponding chiral amide. In an exemplary process, a chiral amino center is introduced during hydrogenation through the use of a chiral hydrogenation catalyst. In selected embodiments, the invention provides methods of preparing amides and amines that include the 1,2,3,4-tetrahydro-N-alkyl-1-naphthalenamine or 1,2,3,4-tetrahydro-1-naphthalenamine substructure.

Process For Preparation Of Trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-1Napthalenamine

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US Patent:
8329950, Dec 11, 2012
Filed:
Jan 25, 2012
Appl. No.:
13/358155
Inventors:
Judy Caron - Westwood MA, US
Thomas Wessel - Lenox MA, US
Karim Lalji - West Vancouver CA, US
Mark Varney - Laguna Niguel CA, US
Roger P. Bakale - Malvern PA, US
Surendra P. Singh - Shrewsbury MA, US
H. Scott Wilkinson - Westborough MA, US
Xiping Su - Woodbridge CT, US
Zhengxu Han - Shrewsbury MA, US
Stefan G. Koenig - Shrewsbury MA, US
Assignee:
Sunovion Pharmaceuticals Inc. - Marlborough MA
International Classification:
C07C 209/62
US Classification:
564308, 564415
Abstract:
One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e. g. , menopause, mood disorders, anxiety disorders, or cognitive disorders. The first component of the pharmaceutical composition is a sedative eszopiclone. The second component of the pharmaceutical composition is trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine. The present invention also relates to a method of treating menopause, perimenopause, mood disorders, anxiety disorders, and cognitive disorders.
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Roger Paul Bakale from Cardiff by the Sea, CA, age ~65 Get Report