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Marc Victor Gorenstein

from Centennial, CO
Age ~73
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Also known as:
Marc V Gorenstein
Related to:
Jonathan T Schilling, 69Sabina Pelta
Connected to:
David B Gorenstein, 75Michael J Gorenstein, 43Gerald J Gorentz, 72Victoria A Gorentz, 71Deborah Gorenz, 51Alida A Gores, 73Carissa Gores, 69Courtney M Gores, 33Frank C Gores, 79James P Gores, 69

Marc Gorenstein Phones & Addresses

  • Centennial, CO
  • 58 N Main St APT 201, Natick, MA 01760
  • Norwood, MA
  • Westerville, OH
  • Milford, MA
  • Needham, MA

Work

Company: Waters Jan 1988 Position: Senior scientist, corporate fellow

Education

Degree: PhD School / High School: University of California, Berkeley 1972 to 1979 Specialities: Physics

Skills

Mass Spectrometry • Chromatography • Lc Ms • Hplc • Spectroscopy • Analytical Chemistry • Proteomics • Protein Chemistry • Uv/Vis • R&D • Science • Characterization • Bioinformatics • Protein Expression • Metabolomics • Validation • Life Sciences • Chemistry

Industries

Chemicals

Resumes

Resumes

Marc Gorenstein Photo 1

Senior Scientist, Corporate Fellow

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Location:
1210 Norwest Dr, Norwood, MA 02062
Industry:
Chemicals
Work:
Waters since Jan 1988
Senior Scientist, Corporate Fellow
Harvard/Smithsonian Center for Astrophysics 1983 - 1988
Officer
Education:
University of California, Berkeley 1972 - 1979
PhD, Physics MIT 1968 - 1972
BS, Physics
Skills:
Mass Spectrometry
Chromatography
Lc Ms
Hplc
Spectroscopy
Analytical Chemistry
Proteomics
Protein Chemistry
Uv/Vis
R&D
Science
Characterization
Bioinformatics
Protein Expression
Metabolomics
Validation
Life Sciences
Chemistry

Business Records

Name / Title
Company / Classification
Phones & Addresses
Marc Gorenstein
Principal
Gorenstein
Business Services at Non-Commercial Site
313 Brookline St, Needham, MA 02492

Publications

Us Patents

Method And Apparatus For Determining The Boundaries Of A Detector Response Profile And For Controlling Processes

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US Patent:
6694265, Feb 17, 2004
Filed:
Sep 7, 2001
Appl. No.:
09/949199
Inventors:
Marc V. Gorenstein - Needham MA
Assignee:
Waters Investments Limited - Delaware MA
International Classification:
G06F 1900
US Classification:
702 22, 703 2
Abstract:
An improved method and apparatus for identifying peaks and for determining the boundaries of those peaks, and boundaries of multiple peaks and shoulders within chromatograms. The method and apparatus effects real time identification and determination of the boundaries of these peaks for the purpose of fraction collection. The method and apparatus determines the boundary of a peak within a detector response profile that comprises data points plotted graphically on an X and Y-axis wherein the X-axis represents a first variable and the Y-axis represents a second variable, each variable having a value. The plot at each of the data points has a slope. Data points having a slope which deviates from a consistent value define a peak, and data points having a slope with a consistent value define a baseline.

Method Of Using Data Binning In The Analysis Of Chromatography/Spectrometry Data

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US Patent:
7072773, Jul 4, 2006
Filed:
Nov 16, 2004
Appl. No.:
10/989533
Inventors:
Robert Stephen Plumb - Milford MA, US
Chris Lee Stumpf - Uxbridge MA, US
Marc V. Gorenstein - Needham MA, US
International Classification:
G06F 19/00
G06F 11/30
H01J 49/00
US Classification:
702 32, 702182, 250281
Abstract:
Disclosed herein is a method of analyzing three-dimensional data obtained from a chromatography/spectrometry process, in particular an LC/MS process using a two-dimensional multi-variant statistical analysis. The LC portion permits separation of analytes within a sample. The information obtained from such a procedure typically depends on retention time (R). As the analytes progress through the system, they enter the MS region of the LC/MS system. There they are ionized and a mass detector then detects these ionized species. The information procured from this procedure is generally reported as intensity for a corresponding m/z value. Therefore, an LC/MS system provides at least three pieces of information. Principle component analysis (PCA) is a robust method of multi-variant analysis of this type of data between different samples. However, typically, PCA analysis is performed using only two-dimensional data.

Method Of Using Data Binning In The Analysis Of Chromatography/Spectrometry Data

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US Patent:
7418352, Aug 26, 2008
Filed:
Jun 30, 2006
Appl. No.:
11/480254
Inventors:
Robert Stephen Plumb - Milford MA, US
Chris Lee Stumpf - Uxbridge MA, US
Marc V. Gorenstein - Needham MA, US
International Classification:
G06F 19/00
G06F 11/30
H01J 49/00
US Classification:
702 32, 702182, 250281, 250282
Abstract:
Disclosed herein is a method of analyzing three-dimensional data obtained from a chromatography/spectrometry process, in particular an LC/MS process using a two-dimensional multi-variant statistical analysis. The LC portion permits separation of analytes within a sample. The information obtained from such a procedure typically depends on retention time (R). As the analytes progress through the system, they enter the MS region of the LC/MS system. There they are ionized and a mass detector then detects these ionized species. The information procured from this procedure is generally reported as intensity for a corresponding m/z value. Therefore, an LC/MS system provides at least three pieces of information. Principle component analysis (PCA) is a robust method of multi-variant analysis of this type of data between different samples. However, typically, PCA analysis is performed using only two-dimensional data.

Apparatus And Method For Identifying Peaks In Liquid Chromatography/Mass Spectrometry Data And For Forming Spectra And Chromatograms

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US Patent:
7645984, Jan 12, 2010
Filed:
Feb 11, 2005
Appl. No.:
10/588967
Inventors:
Marc V. Gorenstein - Needham MA, US
Robert S. Plumb - Milford MA, US
Chris L. Stumpf - Uxbridge MA, US
Assignee:
Waters Technologies Corporation - Milford MA
International Classification:
H01J 49/00
B01D 59/44
G06F 19/00
G01R 23/16
US Classification:
250281, 250282, 250288, 250397, 702 76, 702196, 702 28, 702 32
Abstract:
Chromatograms and mass spectra produced by an LC/MS system are analyzed by creating a two-dimensional data matrix of the spectral and chromatographic data. The two-dimensional matrix can be created by placing the spectra generated by the mass spectrometer portion of the LC/MS system in successive columns of the data matrix. In this way, the rows of the data matrix correspond to chromatographic data and the columns of the data matrix correspond to the spectra. A two-dimensional filter is specified and applied to the data matrix to enhance the ability of the system to detect peaks associated with ions. The two-dimensional filter is specified according to desired criteria. Rank-1 and rank-2 filters can be specified to improve computational efficiency. One method of applying the two-dimensional filter is through convolution of the data matrix with the two-dimensional filter to produce an output data matrix. Peaks corresponding to detected ions are identified in the output data matrix.

Apparatus And Method For Identifying Peaks In Liquid Chromatography/Mass Spectrometry Data And For Forming Spectra And Chromatograms

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US Patent:
8017908, Sep 13, 2011
Filed:
Dec 18, 2009
Appl. No.:
12/641812
Inventors:
Marc V. Gorenstein - Needham MA, US
Robert S. Plumb - Milford MA, US
Chris L. Stumpf - Uxbridge MA, US
Assignee:
Waters Technologies Corporation - Milford MA
International Classification:
H01J 49/26
H01J 49/00
B01D 59/44
US Classification:
250282, 250281, 250288, 250397, 702 76, 702 28, 702 32, 702196
Abstract:
Chromatograms and mass spectra produced by an LC/MS system are analyzed by creating a two-dimensional data matrix of the spectral and chromatographic data. The two-dimensional matrix can be created by placing the spectra generated by the mass spectrometer portion of the LC/MS system in successive columns of the data matrix. In this way, the rows of the data matrix correspond to chromatographic data and the columns of the data matrix correspond to the spectra. A two-dimensional filter is specified and applied to the data matrix to enhance the ability of the system to detect peaks associated with ions. The two-dimensional filter is specified according to desired criteria. Rank-1 and rank-2 filters can be specified to improve computational efficiency. One method of applying the two-dimensional filter is through convolution of the data matrix with the two-dimensional filter to produce an output data matrix. Peaks corresponding to detected ions are identified in the output data matrix.

Generation And Use Of A Catalog Of Polypeptide-Related Information For Chemical Analyses

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US Patent:
8105838, Jan 31, 2012
Filed:
Jun 5, 2006
Appl. No.:
11/914600
Inventors:
Marc V. Gorenstein - Needham MA, US
Scott Geromanos - Middletown NJ, US
Jeffrey Cruz Silva - Beverly MA, US
Guo-Zhong Li - Westborough MA, US
Assignee:
Waters Technologies Corporation - Milford MA
International Classification:
G01N 33/00
US Classification:
436 86, 436 87, 436 89
Abstract:
A method () for performing chemical analyses includes digesting a reference sample to obtain precursors associated with a peptide in the sample (), separating the precursors to determine values associated with retention times of the separated precursors (), ionizing the separated precursors to form precursor ions (), mass analyzing the precursor ions to determine values associated with mass and with ion intensity (), and storing a

Correction Of Deadtime Effects In Mass Spectrometry

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US Patent:
8106350, Jan 31, 2012
Filed:
Feb 22, 2006
Appl. No.:
11/816643
Inventors:
Martin Green - Cheshire, GB
Jason Lee Wildgoose - Stockport, GB
Marc V. Gorenstein - Needham MA, US
Assignee:
Micromass UK Limited - Manchester
International Classification:
H01J 49/26
US Classification:
250282, 250281, 250287, 702 19, 702 28
Abstract:
A method of mass spectrometry is disclosed wherein distortions in a mass spectrum are corrected for by determining or estimating the number of ions Qwhich arrived in an itime bin, wherein: Formula (I) and wherein qis the actual total number of ion arrival events recorded in the itime bin and x is an integer corresponding to the number of time bins which correspond with an estimated deadtime period.

Methods And Apparatus For Performing Retention-Time Matching

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US Patent:
8143066, Mar 27, 2012
Filed:
Jun 5, 2006
Appl. No.:
11/916320
Inventors:
Marc V. Gorenstein - Needham MA, US
Scott J. Geromanos - Middletown NJ, US
Jeffrey Cruz Silva - Beverly MA, US
Guo-Zhong Li - Westborough MA, US
Assignee:
Waters Technologies Corporation - Milford MA
International Classification:
G01N 33/00
US Classification:
436 86, 436 87, 436 89
Abstract:
A method () for analyzing chemicals includes fractionating a complex sample into at least two sample portions that each includes portions of two polypeptides though in different concentration ratios, digesting and performing LC/MS on each of the sample portions (, and associating precursor ions observed via LC/MS with their corresponding polypeptide in response to LC/MS provided intensity data (). A set of precursor ions that has substantially similar intensity ratios in both sample portions is determined to be associated with the same polypeptide.
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Marc Victor Gorenstein from Centennial, CO, age ~73 Get Report