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Donald C Hou

from Newtown, PA
Age ~70
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Also known as:
Donald Hou Poa, Don C Hou, Donald Chou, Donald Hoy, Janet Ethier
Phone and address:
30 Sibelius Dr, Upper Makefield, PA 18940
(215) 504-2851
Related to:
David H Lee, 55Victor Hou, 61Lisa W Hou, 36Edavis Rd Lee, 65Ray Ming Lin, 71Chi M Hou, 99Liwen Ching HouEllen Hou, 74Irene L Hou, 95Liwen Ching, 62Charlene T Hou, 68Jessie Hou, 61Victor C HouIrene HouWilliam C Hou, 68
Connected to:
Amber R Hou, 29Benjamin B Hou, 54Bingshu Hou, 36Chun J Hou, 66Deyi Hou, 43Diane Hou, 30Dongbin Hou, 39Fong Y Hou, 73Frances M Hou, 58Garvy Hou, 64

Donald Hou Phones & Addresses

  • 30 Sibelius Dr, Newtown, PA 18940 (215) 504-2851
  • 14502 Elmhan Ct, Silver Spring, MD 20906 (301) 603-1318
  • Verona, NJ
  • Berkeley, CA
  • Hamilton, NY
  • Malvern, PA
  • Montclair, NJ
  • Buck, PA
  • Brooklyn, NY

Resumes

Resumes

Donald Hou Photo 1

Cmc Consultant, Chempartner And China Gateway

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Location:
30 Sibelius Dr, Newtown, PA 18940
Industry:
Pharmaceuticals
Work:
Shanghai Chempartner
Cmc Consultant, Chempartner and China Gateway
Chempartner/China Gateway Pharmaceutical Development
Svp, Cmc Business
Merck May 2005 - Nov 2009
Associate Director
Solvay Jan 2003 - Jan 2005
Director, Chemistry
Chirex Jan 2000 - Dec 2002
Director, Chemistry
Education:
University of California, Berkeley 1981 - 1983
Columbia University In the City of New York 1976 - 1981
Doctorates, Doctor of Philosophy, Philosophy, Organic Chemistry University of Rochester 1972 - 1976
Bachelors, Bachelor of Science, Chemistry Hamilton High School 1968 - 1972
Skills:
Gmp
Technology Transfer
Drug Development
Organic Chemistry
Pharmaceutical Industry
Cro
Organic Synthesis
R&D
Ind
Glp
Life Sciences
Regulatory Submissions
Good Laboratory Practice
Research and Development
Chemistry
Languages:
English
Donald Hou Photo 2

Associate Director At Schering-Plough Corporation

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Location:
Greater Philadelphia Area
Industry:
Pharmaceuticals
Donald Hou Photo 3

Donald Hou

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Donald Hou Photo 4

Donald Hou

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Publications

Us Patents

Synthesis Of Temozolomide And Analogs

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US Patent:
7087751, Aug 8, 2006
Filed:
Jan 16, 2002
Appl. No.:
10/050488
Inventors:
Shen-Chun Kuo - Union NJ, US
Janet L. Mas - Green Brook NJ, US
Donald Hou - Newtown PA, US
Assignee:
Schering Corporation - Kenilworth NJ
International Classification:
C07D 487/04
C07D 233/60
C07D 233/88
US Classification:
544179, 5483265
Abstract:
This invention relates to a novel process for the synthesis of Temozolomide, an antitumor compound, and analogs, and to intermediates useful in this novel process.

Synthesis Of Temozolomide And Analogs

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US Patent:
7446209, Nov 4, 2008
Filed:
Jun 14, 2006
Appl. No.:
11/453125
Inventors:
Shen-Chun Kuo - Union NJ, US
Janet L. Mas - Green Brook NJ, US
Donald Hou - Newtown PA, US
Assignee:
Schering Corporation - Kenilworth NJ
International Classification:
C07D 233/66
C07D 487/04
US Classification:
5483265, 544179
Abstract:
This invention relates to a novel process for the synthesis of Temozolomide, an antitumor compound, and analogs, and to intermediates useful in this novel process.

Synthesis Of Temozolomide And Analogs

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US Patent:
20050131227, Jun 16, 2005
Filed:
Jan 21, 2005
Appl. No.:
11/040784
Inventors:
Shen-Chun Kuo - Union NJ, US
Janet Mas - Green Brook NJ, US
Donald Hou - Newtown PA, US
International Classification:
C07D487/04
US Classification:
544179000
Abstract:
This invention relates to a novel process for the synthesis of Temozolomide, an antitumor compound, and analogs, and to intermediates useful in this novel process.

Synthesis Of Temozolomide And Analogs

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US Patent:
20090023919, Jan 22, 2009
Filed:
Sep 26, 2008
Appl. No.:
12/239123
Inventors:
Shen-Chun Kuo - Union NJ, US
Janet L. Mas - Green Brook NJ, US
Donald Hou - Newtown PA, US
International Classification:
C07D 257/12
US Classification:
544179
Abstract:
This invention relates to a novel process for the synthesis of Temozolomide, an antitumor compound, and analogs, and to intermediates useful in this novel process.

Synthesis Of 1-(Allyloxycarbonyl)-Methyl-3-(Hydroxyethyl)-4-Beta-Naphthoxythiocarbony Lthio-2-Azetidinones And Hydroxy Protected Analogs Thereof

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US Patent:
47678534, Aug 30, 1988
Filed:
Jul 21, 1986
Appl. No.:
6/887394
Inventors:
Donald Hou - Verona NJ
Assignee:
Schering Corporation - Kenilworth NJ
International Classification:
C07D20508
C07D51304
C07D40312
C07F 718
US Classification:
540357
Abstract:
A multi-step stereospecific process for preparing (3S,4R,5R)-1-(allyloxycarbonyl)-methyl-3-(1-hydroxyethyl)-4-beta-naphthoxy thiocarbonylthio-2-azetidinones, stereoisomers thereof or hydroxy protected analogs thereof from anhydropenicillin. The azetidinones are intermediates useful for producing penems which are a known group of antibacterial compounds. The process involves protecting the hydroxy group of anhydropenicillin with a readily removable hydroxy protecting group, then converting the resulting compound by ozonolysis followed by reaction with a trialklyl phosphite, then hydrolysis to remove the methylidene group at the 2-position of anhydropenicillin. The resulting compound is converted to the unprotected 4-beta-naphthoxy thiocarbonylthio derivative by reaction with allyl alcohol and HCl followed by reaction with O-2-napththalenylcarbonochloridothioate, or to the protected compound by reaction with silver imidazolate and allyl alcohol followed by reaction with O-2-naphthalenylcarbonochloridothioate.

Process For Preparing Intermediates For The Synthesis Of D1 Antagonists

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US Patent:
56706669, Sep 23, 1997
Filed:
May 19, 1995
Appl. No.:
8/445404
Inventors:
Donald Hou - Verona NJ
Richard W. Draper - North Caldwell NJ
Gary M. Lee - Murray Hill NJ
Janet L. Mas - Scotch Plains NJ
Assignee:
Schering Corporation - Kenilworth NJ
International Classification:
C07D31728
C07D31906
US Classification:
549373
Abstract:
Disclosed are a process and intermediates of the formulae ##STR1## wherein X. sup. - is halide, BF. sub. 4. sup. -, R. sup. 3 SO. sub. 3. sup. -, wherein R. sup. 3 is C. sub. 1 -C. sub. 6 alkyl, CF. sub. 3, C. sub. 1 -C. sub. 6 alkylphenyl or phenyl, and Q is a group of the formula ##STR2## wherein R is C. sub. 1 -C. sub. 6 alkyl; useful for preparing benzazepine intermediates of the formula ##STR3## These benzazepine intermediates are useful for preparing benzazepines having activity as selective D1 receptor antagonists.

Process For Preparing Benzazepine Intermediates For The Synthesis Of D1 Antagonists

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US Patent:
54611474, Oct 24, 1995
Filed:
Sep 27, 1993
Appl. No.:
8/127667
Inventors:
Donald Hou - Verona NJ
Richard W. Draper - North Caldwell NJ
Gary M. Lee - Murray Hill NJ
Janet L. Mas - Scotch Plains NJ
Assignee:
Schering Corporation - Kenilworth NJ
International Classification:
C07C21770
C07C27116
C07D22314
US Classification:
540576
Abstract:
Disclosed are a process and intermediates of the formula ##STR1## wherein R is --CH. sub. 3 or --C(O)--OR. sup. 1, and R. sup. 1 is C. sub. 1 -C. sub. 6 alkyl or --CH. sub. 2 C. sub. 6 H. sub. 5 ; or the formula ##STR2## wherein: R. sup. 2 is H or OH, R is --C(O)OR. sup. 1 and R. sup. 1 is C. sub. 1 -C. sub. 6 alkyl or --CH. sub. 2 C. sub. 6 H. sub. 5, or where R. sup. 2 is H, R can also be CH. sub. 3 ; for preparing benzazepine intermediates of the formula ##STR3## The benzazepine intermediates are useful for preparing benzazepines having activity as selective D1 receptor antagonists.

Synthesis Of Azetidinones Using Cucl

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US Patent:
48763381, Oct 24, 1989
Filed:
Jun 7, 1988
Appl. No.:
7/203385
Inventors:
Donald Hou - Verona NJ
Dinesh Gala - East Brunswick NJ
Martin Steinman - Livingston NJ
Assignee:
Schering Corporation - Kenilworth NJ
International Classification:
C07D70508
US Classification:
540357
Abstract:
A multi-step stereospecific process for preparing (3S,4R,5R)-1-(allyloxycarbonyl)-methyl-3-(1-hydroxyethyl)-4-beta-naphthoxy thi ocarbonylthio-2-azetidinone, stereoisomers thereof or hydroxy protected analogs thereof from anhydropenicillin. The azetidinones are intermediates useful for producing penems which are a known group or antibacterial compounds. The process involves protecting the hydroxy group of anhydropenicillin with a readily removable hydroxy protecting group, then reacting the resulting compound by treatment with oxygen and cuprous chloride in methanol, followed by reaction with ozone to produce a hydroxy protected dithiobis azetidinone and convert the methylidene groups originally in the 2-position of anhydropenicillin and in the bis-compound, to a (methoxycarbonyl)-carbonyl group. The resulting compound is converted to the unprotected dithiobis compound by reaction with ammonium hydroxide, then allyliodoacetate followed by an acid. Reaction of the resulting compound with zinc and a mineral acid followed by reaction with 0-2-naphthalenylcarbonochloridothioate converts the unprotected dithiobis compound to 1-(allyloxycarbonyl)methyl-3-(1-hydroxyethyl)-4-beta-naphthoxy (thiocarbonyl)thio-2-azetidinone.
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Donald C Hou from Newtown, PA, age ~70 Get Report