Resumes
Resumes
Bu Wang Phones & Addresses
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San Diego, CA
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San Marcos, CA
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New York, NY
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Nashua, NH
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Chelmsford, MA
Publications
Us Patents
Intracellular Delivery Of Biomolecules To Induce Tolerance
View pageUS Patent:
20190111082, Apr 18, 2019
Filed:
May 3, 2017
Appl. No.:
16/098404
Inventors:
- Watertown MA, US
Bu WANG - Watertown MA, US
Scott LOUGHHEAD - Watertown MA, US
Howard BERNSTEIN - Cambridge MA, US
Armon R. SHAREI - Watertown MA, US
Finola MOORE - Watertown MA, US
Bu WANG - Watertown MA, US
Scott LOUGHHEAD - Watertown MA, US
Howard BERNSTEIN - Cambridge MA, US
Armon R. SHAREI - Watertown MA, US
Finola MOORE - Watertown MA, US
International Classification:
A61K 35/18
A61P 37/06
C12M 1/12
C12N 15/85
C12M 3/06
A61K 39/385
A61K 35/19
C12N 5/078
A61P 37/06
C12M 1/12
C12N 15/85
C12M 3/06
A61K 39/385
A61K 35/19
C12N 5/078
Abstract:
The present invention provides methods for inducing tolerance and/or suppressing an immune response to an antigen by passing a cell suspension containing an anucleate cell through a constriction, wherein the constriction deforms the cell thereby causing a perturbation of the cell such that an antigen and/or tolerogenic factor enters the cell. In some embodiments, the anucleate cell is delivered to an individual and the antigen is delivered to and processed in a tolerogenic environment to induce tolerance and/or suppress an immune response to the antigen.