Wallace G Strycker

40617602, Dec 6, 1977

Oct 4, 1976

5/729164

Herbert John Havera - Edwardsburg MI
Wallace Glenn Strycker - Goshen IN

Miles Laboratories, Inc. - Elkhart IN

A61K 31445

424267

Compounds having the generic structure, ##STR1## and their nontoxic, pharmacologically acceptable salts are useful in the chemotherapy of arrhythmias in individuals for whom such therapy is indicated. In the preceding structural formula: R. sup. 1 is a 2-pyridyl, 3-pyridyl, or 4-pyridyl radical; n is an integer of the set 1-3; and R. sup. 2 is a hydrogen atom, a hydroxyl, or an equivalent alkoxyl group having from 1 to 3 carbon atoms.

52120660, May 18, 1993

Nov 14, 1991

7/791380

James P. Albarella - Granger IN
Todd K. Cast - South Bend IN
David W. Michaels - Elkhart IN
Wallace G. Strycker - Goshen IN

Miles Inc. - Elkhart IN

C12Q 154
C12Q 128

435 28

Disclosed is a novel diagnostic reagent system for the detection of hydroperoxides or substances which react with peroxidatively active substances resulting in the liberation of hydroperoxides which reagent system comprises a chromogenic oxidation indicator and a peroxidase or a peroxidatively active substance, together with an inhibitor of color generation selected from the group of 1,4-disubstituted semicarbazides, thiosemicarbazides and 1,5-disubstituted carbazides as inhibitors of color generation. By inhibiting the generation of color formed by oxidation of the chromogenic indicator, the indicator's usefulness in discriminating between varying concentrations of analyte is enhanced.

43049133, Dec 8, 1981

Oct 2, 1980

6/193150

Herbert J. Havera - Edwardsburg MI
Wallace G. Strycker - Goshen IN

Miles Laboratories, Inc. - Elkhart IN

C07D45506

546 95

Disclosed are trans-2-substituted-amido-hexahydrobenzo[a]quinolizines represented by the formula: ##STR1## In the above formula, R. sup. 1 and R. sup. 2 are independently --H or --OCH. sub. 3 or when taken together are ##STR2## R. sup. 3 is --H or --CH. sub. 3 and R. sup. 4 is ##STR3## These compounds, and their pharmacologically acceptable, non-toxic, acid addition salts are useful as anti-hypertensive agents.

39949044, Nov 30, 1976

Mar 8, 1976

5/664920

Herbert John Havera - Edwardsburg MI
Wallace Glenn Strycker - Goshen IN

Miles Laboratories, Inc. - Elkhart IN

C07D40114

2602937

Compounds having the generic structure, ##SPC1## And their nontoxic, pharmacologically acceptable salts are useful in the chemotherapy of arrhythmias in individuals for whom such therapy is indicated. In the preceding structural formula: R. sup. 1 is a 2-pyridyl, 3-pyridyl, or 4-pyridyl radical; n is an integer of the set 1-3; and R. sup. 2 is a hydrogen atom, a hydroxyl, or an equivalent alkoxyl group having from 1 to 3 carbon atoms.

41105362, Aug 29, 1978

Apr 18, 1977

5/788154

Herbert J. Havera - Edwardsburg MI
Wallace G. Strycker - Goshen IN

Miles Laboratories, Inc. - Elkhart IN

C07D41314
A61K 31535

544139

Derivatives of 5-(indol-3-yl)hydantoin characterized by the generic structural formula, ##STR1## and their pharmacologically compatible salts are useful in the treatment of cardiac arrythmias in individuals for whom such therapy is indicated. In the preceding structural formula, A is a hydrogen atom, a halogeno, alkyl, hydroxyl, or an alkoxyl radical; n is 0 or 1; R is a hydrogen atom or a phenyl group; X is a methylene, ethylene, trimethylene, or 2-hydroxytrimethylene radical; and Z is a monoalkylamino radical containing 1-4 carbon atoms, a dialkylamino radical containing 2-8 carbon atoms, a morpholino, piperid-1-yl, 4-phenyl-piperid-1-yl, or a 4-hydroxy-4-phenyl-piperid-1-yl radical.

40062325, Feb 1, 1977

Nov 15, 1974

5/524297

Shin Hayao - Tokyo, JA
Herbert John Havera - Edwardsburg MI
Wallace Glenn Strycker - Goshen IN

Miles Laboratories, Inc. - Elkhart IN

A61K 31495

424250

3-substituted-5,5-diphenylhydantoin derivatives in which the 5,5-diphenylhydantoin moiety is attached at C. sub. 3 by a loweralkylene bridge to a 4-phenyl-1-piperidyl, 4-hydroxy-4-phenyl-1-piperidyl, 4-phenyl-1,2,3,6-tetrahydropyridyl, 4-phenyl-1-piperazinyl, or loweralkylamino group are useful in the treatment of cardiac arrhythmias in mammals. One or both of the 5,5-diphenyl substituents optionally can be substituted in the ortho-, meta-, or para-positions with halogeno, lowerakyl, loweralkoxy, amino or nitro groups.

42307104, Oct 28, 1980

Oct 23, 1978

5/953356

Herbert J. Havera - Edwardsburg MI
Wallace G. Strycker - Goshen IN

Miles Laboratories, Inc. - Elkhart IN

A61K 3147
C07D45506

424258

Disclosed are novel 2-substituted anilino-hexahydrobenzo[a]quinolizines of the formula: ##STR1## wherein R and R' are independently H or --OCH. sub. 3 and R" is ##STR2## These compounds, and their pharmacologically acceptable, non-toxic acid addition salts are useful as anti-hypertensive agents. Certain of the compounds disclosed herein elicit this effect without producing concomitant cardiac stimulation.