Thomas Peter Nigra

6586473, Jul 1, 2003

Jan 12, 2000

09/481813

Thomas P. Nigra - Easton MD
Eugene H. Gans - Westport CT

Medicis Pharmaceutical Corporation - Scottsdale AZ

A61K 3120

514560, 514723

A topical composition for delivering an effective amount of a pharmaceutically acceptable drug, including laureth-4, propylene glycol, dimethylsorbide, and a pharmaceutically acceptable diluent is described as an improved drug delivery composition. Further, a method of transepithelial delivery of a drug to a human by topical application to the skin of a human of a composition including laureth-4, propylene glycol, dimethylsorbide, a pharmaceutically acceptable diluent of water and ethanol and an effective amount of a pharmaceutically acceptable drug has beneficial delivery effects.

20080207545, Aug 28, 2008

Oct 20, 2004

11/885384

Glenn D. Hoke - Mt. Airy MD, US
Thomas P. Nigra - Washington DC, US

A61K 31/7088
A61P 17/00
A61P 35/04
A61P 13/00

514 44

The invention relates generally to the use of anti-sense oligonucleotides, small interfering RNA, and ribozymes to modulate expression of the human steroid 5α-reductase gene and thereby modulate levels of dihydrotestosterone (DHT). Elevated levels of DHT are associated with various disorders including, but not limited to, skin diseases, hair loss, hirsuitism, and benign prostatic hyperplasia. The invention specifically relates to formulations of these anti-sense oligonucleotides, small interfering RNA, and ribozymes for administration to treat and prevent disorders

60281057, Feb 22, 2000

Jun 7, 1995

8/484548

Thomas P. Nigra - Easton MD

A01N 3700
A01N 3114

514560

A topical composition for delivering an effective amount of a pharmaceutically acceptable drug, including laureth-4, propylene glycol, dimethylsorbide, and a pharmaceutically acceptable diluent is described as an improved drug delivery composition. Further, a method of transepithelial delivery of a drug to a human by topical application to the skin of a human of a composition including laureth-4, propylene glycol, dimethylsorbide, a pharmaceutically acceptable diluent of water and ethanol and an effective amount of a pharmaceutically acceptable drug has beneficial delivery effects.