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Susan G Frackman

from Madison, WI
Age ~74
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Also known as:
Sue G Frackman
Phone and address:
3206 Tallyho Ln, Madison, WI 53705
(608) 236-9405
Related to:
Anna E Frackman, 35
Connected to:
Kyle E Frackman, 45Adam Frackowiak, 45Brandon J Fractious, 40Miriam A Fraction, 35Agnieszka Fraczek, 47Edyta Fraczek, 44Urszula S Fraczek, 78Rhonda L Fraczkowski, 60Zofia A Fraczkowska, 72Heather Frad, 28

Susan Frackman Phones & Addresses

  • 3206 Tallyho Ln, Madison, WI 53705 (608) 236-9405
  • Milwaukee, WI
  • Chicago, IL
  • 3206 Tallyho Ln, Madison, WI 53705 (608) 751-5610

Work

Company: Promega 1997 to 2008 Position: Senoir research scientist

Education

Degree: Doctorates, Doctor of Philosophy School / High School: University of Iowa 1979 to 1984 Specialities: Microbiology

Skills

Molecular Biology • Biotechnology

Emails

s***[email protected]

Industries

Biotechnology

Resumes

Resumes

Susan Frackman Photo 1

Research And Development Project Manager

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Location:
Madison, WI
Industry:
Biotechnology
Work:
Promega 1997 - 2008
Senoir Research Scientist
Promega 1997 - 2008
Research and Development Project Manager
Education:
University of Iowa 1979 - 1984
Doctorates, Doctor of Philosophy, Microbiology
Skills:
Molecular Biology
Biotechnology

Publications

Us Patents

Luminescence-Based Methods And Probes For Measuring Cytochrome P450 Activity

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US Patent:
7692022, Apr 6, 2010
Filed:
Sep 19, 2003
Appl. No.:
10/665314
Inventors:
James J. Cali - Verona WI, US
Dieter Klaubert - Arroyo Grande CA, US
William Daily - Santa Maria CA, US
Samuel Kin Sang Ho - New Bedford MA, US
Susan Frackman - Madison WI, US
Erika Hawkins - Madison WI, US
Keith V. Wood - Mount Horeb WI, US
Assignee:
Promega Corporation - Madison WI
International Classification:
C07D 277/68
C07D 417/04
US Classification:
548178, 530330, 530331
Abstract:
The present invention provides methods, compositions, substrates, and kits useful for analyzing the metabolic activity in cells, tissue, and animals and for screening test compounds for their effect on cytochrome P450 activity. In particular, a one-step and two-step methods using luminogenic molecules, e. g. luciferin or coelenterazines, that are cytochrome P450 substrates and that are also bioluminescent enzyme, e. g. , luciferase, pro-substrates are provided. Upon addition of the luciferin derivative or other luminogenic molecule into a P450 reaction, the P450 enzyme metabolizes the molecule into a bioluminescent enzyme substrate, e. g. , luciferin and/or luciferin derivative metabolite, in a P450 reaction. The resulting metabolite(s) serves as a substrate of the bioluminescent enzyme, e. g. , luciferase, in a second light-generating reaction.

Luminescence-Based Methods And Probes For Measuring Cytochrome P450 Activity

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US Patent:
8106052, Jan 31, 2012
Filed:
Apr 5, 2010
Appl. No.:
12/754164
Inventors:
James J. Cali - Verona WI, US
Dieter Klaubert - Arroyo Grande CA, US
William Daily - Santa Maria CA, US
Samuel Kin Sang Ho - New Bedford MA, US
Susan Frackman - Madison WI, US
Erika Hawkins - Madison WI, US
Keith V. Wood - Mount Horeb WI, US
Assignee:
Promega Corporation - Madison WI
International Classification:
A61K 31/403
A61K 31/4164
A61K 31/422
A61K 31/437
A61K 31/4985
C07D 413/04
C07D 417/04
C07D 471/04
C07D 487/04
US Classification:
514249, 514299, 514367, 514375, 514393, 548466, 548238, 5483114, 548146, 544236, 546113
Abstract:
The present invention provides methods, compositions, substrates, and kits useful for analyzing the metabolic activity in cells, tissue, and animals and for screening test compounds for their effect on cytochrome P450 activity. In particular, a one-step and two-step methods using luminogenic molecules, e. g. luciferin or coelenterazines, that are cytochrome P450 substrates and that are also bioluminescent enzyme, e. g. , luciferase, pro-substrates are provided. Upon addition of the luciferin derivative or other luminogenic molecule into a P450 reaction, the P450 enzyme metabolizes the molecule into a bioluminescent enzyme substrate, e. g. , luciferin and/or luciferin derivative metabolite, in a P450 reaction. The resulting metabolite(s) serves as a substrate of the bioluminescent enzyme, e. g. , luciferase, in a second light-generating reaction.

Luminescence-Based Methods And Probes For Measuring Cytochrome P450 Activity

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US Patent:
20090023173, Jan 22, 2009
Filed:
Jul 3, 2008
Appl. No.:
12/217374
Inventors:
James J. Cali - Verona WI, US
Dieter Klaubert - Arroyo Grande CA, US
William Daily - Santa Maria CA, US
Samuel Kin Sang Ho - New Bedford MA, US
Susan Frackman - Madison WI, US
Erika Hawkins - Pembroke, CA
Keith V. Wood - Mt. Horeb WI, US
Assignee:
Promega Corporation - Madison WI
International Classification:
C12Q 1/42
C07D 277/62
C07D 415/00
C12Q 1/26
C07D 487/04
US Classification:
435 18, 548152, 544236, 435 25
Abstract:
The invention provides compounds, compositions, methods, substrates, and kits useful for analyzing the metabolic activity in cells, tissue, and animals and for screening test compounds for their effect on cytochrome P450 activity. In particular, a one-step and two-step methods using luminogenic molecules, e.g. luciferins or coelenterazines, that are cytochrome P450 substrates and that are also bioluminescent enzyme, e.g., luciferase, pro-substrates are provided. The present method further provides a method for stabilizing and prolonging the luminescent signal in a luciferase-based assay using luciferase stabilizing agents such as reversible luciferase inhibitors.

In Vitro Phage Lambda Dna Packaging System

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US Patent:
55081878, Apr 16, 1996
Filed:
Dec 23, 1993
Appl. No.:
8/173743
Inventors:
Susan G. Frackman - Shorewood WI
Phillip P. Franciskovich - Brown Deer WI
James F. Jolly - Glendale WI
Robert A. Luhm - Mequon WI
William A. Riedl - Grafton WI
Assignee:
Pharmacia P-L Biochemicals, Inc. - Milwaukee WI
International Classification:
C12N 120
C12N 700
C12N 1509
US Classification:
4352351
Abstract:
A bacterial preparation capable of packaging phage. lambda. DNA is disclosed. This preparation is in lyophilized form and is stable at ambient temperature. In a preferred form, the preparation contains an over-expressed terminase protein, is prepared from the bacterial strain E. coli Cla [. lambda. c/857 Sam7. DELTA. (cos-Nu1-A)::Kn. sup. r ]/. lambda. pTER and is capable of a packaging efficiency of at least 1. times. 10. sup. 8 pfu/. mu. g wild type. lambda. DNA. The present invention is also a method of creating a phage. lambda. DNA packaging extract comprising the steps of preparing a bacterial extract capable of packaging phage. lambda. and lyophilizing said extract.

Luminescence-Based Methods And Probes For Measuring Cytochrome P450 Activity

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US Patent:
20170191985, Jul 6, 2017
Filed:
Jan 18, 2017
Appl. No.:
15/408662
Inventors:
- Madison WI, US
Dieter Klaubert - Arroyo Grande CA, US
William Daily - Santa Maria CA, US
Samuel Kin Sang Ho - New Bedford MA, US
Susan Frackman - Madison WI, US
Erika Hawkins - Madison WI, US
Keith V. Wood - Mount Horeb WI, US
International Classification:
G01N 33/50
G01N 33/58
C12Q 1/66
Abstract:
The invention provides compounds, compositions, methods, substrates, and kits useful for analyzing the metabolic activity in cells, tissue, and animals and for screening test compounds for their effect on cytochrome P450 activity. In particular, a one-step and two-step methods using luminogenic molecules, e.g. luciferins or coelenterazines, that are cytochrome P450 substrates and that are also bioluminescent enzyme, e.g., luciferase, pro-substrates are provided. The present method further provides a method for stabilizing and prolonging the luminescent signal in a luciferase-based assay using luciferase stabilizing agents such as reversible lucifetrase inhibitors.

Luminescence-Based Methods And Probes For Measuring Cytochrome P450 Activity

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US Patent:
20140380514, Dec 25, 2014
Filed:
Jun 30, 2014
Appl. No.:
14/319219
Inventors:
- Madison WI, US
Dieter Klaubert - Arroyo Grande CA, US
William Daily - Santa Maria CA, US
Samuel Kin Sang Ho - New Bedford MA, US
Susan Frackman - Madison WI, US
Erika Hawkins - Madison WI, US
Keith V. Wood - Mt. Horeb WI, US
International Classification:
C12Q 1/66
A61K 49/00
G01N 33/58
US Classification:
800 3, 435 8, 424 96, 506 10
Abstract:
The invention provides compounds, compositions, methods, substrates, and kits useful for analyzing the metabolic activity in cells, tissue, and animals and for screening test compounds for their effect on cytochrome P450 activity. In particular, a one-step and two-step methods using luminogenic molecules, e.g. luciferins or coelenterazines, that are cytochrome P450 substrates and that are also bioluminescent enzyme, e.g., luciferase, pro-substrates are provided. The present method further provides a method for stabilizing and prolonging the luminescent signal in a luciferase-based assay using luciferase stabilizing agents such as reversible luciferase inhibitors.
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Susan G Frackman from Madison, WI, age ~74 Get Report