Inventors:
Sarma Duddu - Redwood City CA, US
Srinivas Palakodaty - Foster City CA, US
Danforth Miller - San Carlos CA, US
Alan R. Kugler - Montara CA, US
Christopher Frantz - Sunnyvale CA, US
Trixie Tan - Daly City CA, US
Richard Malcolmson - San Mateo CA, US
Keith Washco - Fremont CA, US
Theresa Sweeney - El Granada CA, US
Thomas E. Tarara - Burlingame CA, US
Sarvajna Dwivedi - Redwood City CA, US
Michael A. Eldon - Redwood City CA, US
Assignee:
Nektar Therapeutics - San Carlos CA
International Classification:
A61K 9/14
A61K 31/70
Abstract:
A composition includes particles including at least about 95 wt % of amphotericin B, wherein the particles have a mass median diameter ranging from about 1. 1 μm to about 1. 9 μm. Another composition also includes particles including at least about 95 wt % of amphotericin B, wherein at least about 80 wt % of the particles have a geometric diameter ranging from about 1. 1 μm to about 1. 9 μm. Yet another composition includes particles including amphotericin B, wherein the particles have a mass median diameter less than about 1. 9 μm, and wherein the amphotericin B has a crystallinity level of at least about 20%. Unit dosage forms, delivery systems, and methods may involve similar compositions.