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Silvia Corvera

from Westborough, MA
Age ~65
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Also known as:
Sylvia Corvera, Silvia Czeck, Corvera Silvia
Phone and address:
75 Ruggles St, Westboro, MA 01581
(508) 366-8641
Related to:
Manuel A Fernandez, 81Taryn Fernandez Akaka, 60
Connected to:
Claudia Corvera, 50Connie Corvera, 52Daniel A Corvera, 43Diego A Corvera, 35Mario Corvera, 44Rodolfo B Corvera, 43Donna L Corvese, 68Amanda B Corvetto, 38Debra J Corvey, 71Rebecca J Corvey, 71

Silvia Corvera Phones & Addresses

  • 75 Ruggles St, Westborough, MA 01581 (508) 366-8641
  • 18 Waterline Dr, Mashpee, MA 02649 (508) 477-1850
  • Wrentham, MA
  • New Rochelle, NY
  • Palo Alto, CA
  • North Attleboro, MA
  • 75 Ruggles St, Westborough, MA 01581

Publications

Us Patents

Methods And Compositions For Controlling Appetite And Modulating Insulin Sensitivity

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US Patent:
7767402, Aug 3, 2010
Filed:
Jun 21, 2004
Appl. No.:
10/873364
Inventors:
Silvia Corvera - Westborough MA, US
Assignee:
University of Massachusetts - Boston MA
International Classification:
G01N 33/566
G01N 33/567
C12N 5/0775
A61K 38/00
US Classification:
435 71, 435 78, 435333, 435334, 435335, 530303, 530304, 536 231
Abstract:
The invention features methods of enhancing whole body insulin sensitivity by modulating the endoplasmic reticulum (ER) stress response pathway in adipose cells. In one aspect, the methods involve targeting chaperone proteins important in the ER stress response pathway, for example, BiP and ERO-1. Another aspect features targeting the upstream transcription factors (e. g. , CHOP-1 and XBP-1) of the genes encoding the chaperone proteins (and/or other ER proteins). Screening assays for identification of modulators of these ER proteins and/or transcription factors are also featured.

Lipid Binding Molecules And Methods Of Use

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US Patent:
20040192601, Sep 30, 2004
Filed:
Aug 4, 2003
Appl. No.:
10/634679
Inventors:
Silvia Corvera - Westborough MA, US
David Lambright - Marlboro MA, US
International Classification:
A61K049/00
G01N033/53
C07K014/775
US Classification:
514/012000, 424/009600, 530/324000, 435/007200
Abstract:
The invention relates to new lipid binding molecules that include a lipid binding domain and a reporter group. The new molecules can be used, for example, to detect and visualize lipids, such as phosphatidylinositol 3-phosphate.

Modulation Of Apoptosis

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US Patent:
20050123571, Jun 9, 2005
Filed:
Jun 7, 2004
Appl. No.:
10/863012
Inventors:
Aldo Rossini - Sudbury MA, US
Rita Bortell - Shirley MA, US
Dale Greiner - Hubbardston MA, US
John Mordes - Waban MA, US
Silvia Corvera - Westborough MA, US
Malini Pandarpurkar - Farmington Hills MI, US
Helle Markholst - Charlottenlund, DK
Lars Hornum - Kirke Eskilstrup, DK
International Classification:
C12Q001/68
C07H021/04
C12N009/64
A61K039/00
US Classification:
424277100, 435006000, 435069100, 435226000, 435320100, 435325000, 536023200
Abstract:
The present invention relates, at least in part, to methods of modulating apoptosis in cells, comprising contacting the cell with a compound that modulates the expression, post-translational modification, or activity of Ian4, leucine-rich protein of 130 kD, GRP78, GRP94, or hsp60. The subject methods can be used to treat a variety of different disorders, for example, autoimmune disease and neoplasia. The invention also pertains to methods for identifying compounds that modulates the activity of Ian-4, leucine-rich protein of 130 kD, GRP78, GRP94, or hsp60.

Method Of Identifying Protein Kinase Modulators And Uses Therefore

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US Patent:
20060035301, Feb 16, 2006
Filed:
Jan 26, 2005
Appl. No.:
11/044652
Inventors:
Silvia Corvera - Westborough MA, US
Assignee:
UNIVERSITY OF MASSACHUSETTS - Boston MA
International Classification:
C12Q 1/48
US Classification:
435015000
Abstract:
Methods of identifying AMPK or AK modulators are provided. In particular, methods that feature identifying modulators of AK and its associated substrates (including AMP, ATP or AMP and ATP) or AMPK or activities associated therewith, are provided. Therapeutic methods utilizing compounds identified according to the methods of the invention are also provided.

Receptor-Activated Reporter Systems

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US Patent:
59898933, Nov 23, 1999
Filed:
Aug 8, 1994
Appl. No.:
8/287537
Inventors:
Michael P. Czech - Wrentham MA
Silvia Corvera - Wrentham MA
Assignee:
University of Massachusetts Medical Center - Worcester MA
International Classification:
C12N 121
US Classification:
4352523
Abstract:
The invention discloses a chimeric GLUT transporter including a GLUT receptor polypeptide fused to a domain of a detectable heterologous polypeptide and cells expressing such reporter constructs. Cells expressing a detectably-tagged chimeric GLUT transporter are used in methods of screening candidate compounds for their ability to agonize or antagonize an interaction between a ligand and a receptor, e. g. , insulin. In addition, a 30 amino acid intracellular retention sequence is disclosed.

Targeting Nrip1 To Alleviate Metabolic Disease

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US Patent:
20220220461, Jul 14, 2022
Filed:
Oct 8, 2021
Appl. No.:
17/497367
Inventors:
- Boston MA, US
Emmanouela Tsagkaraki - Worcester MA, US
Sarah M. Nicoloro - Holden MA, US
Silvia Corvera - Westborough MA, US
International Classification:
C12N 9/22
C12N 15/11
C12N 5/077
C12N 15/90
A61P 3/04
A61K 35/35
Abstract:
Provided herein are methods and compositions for disrupting expression of nuclear receptor interacting protein 1 (Nrip1) in adipose cells, and methods of use of such adipose cells for treating, or reducing risk of, a condition associated with an elevated body mass index (BMI).

Human Adipose Tissue White And `Brown-On-White` Progenitors For Reconstructive And Metabolic Therapies

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US Patent:
20210284964, Sep 16, 2021
Filed:
Jan 21, 2021
Appl. No.:
17/154147
Inventors:
- Boston MA, US
Silvia Corvera - Westborough MA, US
International Classification:
C12N 5/077
C12N 5/071
A61K 35/28
Abstract:
Methods for preparation of prospectively identified human adipose stem cells enriched populations thereof, e.g., for therapy.

Human Adipose Tissue Progenitors For Autologous Cell Therapy For Lipodystrophy

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US Patent:
20210095251, Apr 1, 2021
Filed:
Aug 10, 2018
Appl. No.:
16/634377
Inventors:
- Boston MA, US
Silvia Corvera - Westborough MA, US
International Classification:
C12N 5/077
A61K 35/35
Abstract:
Methods for preparation of human adipose stem cells, enriched populations thereof, and white adipose cells derived therefrom, for treatment of lipodystrophy.
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Silvia Corvera from Westborough, MA, age ~65 Get Report