US Patent:
20190314347, Oct 17, 2019
Inventors:
- Burnaby, CA
Yingzhi BI - Plainsboro NJ, US
Shuai CHEN - Wyncote PA, US
Bruce D. DORSEY - Ambler PA, US
Dimitar B. GOTCHEV - Hatboro PA, US
Richard James HOLLAND - Vancouver, British Columbia, CA
Ramesh KAKARLA - Doylestown PA, US
Duyan NGUYEN - Ambler PA, US
Mark Christopher WOOD - Port Moody, British Columbia, CA
International Classification:
A61K 31/4375
C07D 471/14
C07D 495/14
C07D 513/14
C07D 491/147
C07D 491/22
C07F 9/6561
A61K 31/683
A61K 31/7105
A61K 9/51
A61P 31/20
Abstract:
The present invention includes substituted pyridinone-containing tricyclic compounds, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infection in a patient. In certain embodiments, the compounds and compositions of the invention inhibit and/or reduce HBsAg secretion.