US Patent:
20210324056, Oct 21, 2021
Inventors:
- Tokyo, JP
Chad J. SWANSON - Woodcliff Lake NJ, US
Yong ZHANG - Woodcliff Lake NJ, US
Shobha DHADDA - Woodcliff Lake NJ, US
Jinping WANG - Woodcliff Lake NJ, US
Lynn KRAMER - Woodcliff Lake NJ, US
International Classification:
C07K 16/18
A61K 31/542
A61P 25/28
Abstract:
Provided herein are methods of reducing clinical decline in a subject having early Alzheimer's disease, methods of converting an amyloid positive subject having early Alzheimer's disease to amyloid negative, methods of reducing brain amyloid level in a subject, and methods of preventing Alzheimer's disease, the methods comprising administering a composition comprising a therapeutically effective amount of at least one anti-Aβ protofibril antibody. In some embodiments, the subject is ApoE4-positive. In some embodiments, the at least one anti-Aβ protofibril antibody is BAN2401.