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Sharon B Shechter

from Andover, MA
Age ~54
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Also known as:
Sagi S Shechter, Shechter Sharon Bright, Sharon Bright, Sharon Schecter, Shechter Sagi, Sharon R
Related to:
Janet M Shechter, 68
Connected to:
Allen B Shechter, 73Asaf Shechter, 45Aya Shechter, 44Joel L Shechter, 78Oded Shechter, 75Allen L Shechtman, 67Barbara R Shechtman, 79Ellen H Shechtman, 74Karl J Shechtman, 93Melanie G Shechtman, 67

Sharon Shechter Phones & Addresses

  • Andover, MA
  • North Conway, NH
  • Cowan, TN
  • Manchester, TN
  • 24 Summit St, North Andover, MA 01845 (978) 258-1111 (978) 655-1558
  • Madison, NH
  • Reading, MA
  • Newton, MA
  • 18 Ivy Ln, Andover, MA 01810

Education

Degree: Graduate or professional degree

Resumes

Resumes

Sharon Shechter Photo 1

Drug Design

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Location:
Andover, MA
Industry:
Pharmaceuticals
Work:
Silicon Therapeutics
Project Manager
Silicon Therapeutics
Principal Investigator
Shechter Computational Solutions
Chief Executive Officer
Karyopharm Therapeutics Inc. Dec 2009 - Oct 2013
Founding Member and Head of Computational Discovery
Karyopharm Therapeutics Inc. Jan 2012 - Jul 2013
Lead Scientist, Project Manager and Efficacy Screening
Education:
University of Massachusetts Lowell 2017 - 2021
Doctorates, Doctor of Philosophy, Biochemistry, Philosophy Northeastern University 2004 - 2007
Master of Science, Masters, Master of Arts, Bioinformatics University of Antwerp 1995 - 1997
Master of Business Administration, Masters, Business University of Antwerp 1993 - 1995
Master of Business Administration, Masters, Business Administration The Hebrew University of Jerusalem 1992 - 1995
Bachelor of Applied Science, Bachelors The Hebrew University of Jerusalem 1989 - 1991
Bachelor of Applied Science, Bachelors Yigal Alon High School
The Hebrew University of Jerusalem
Skills:
Biotechnology
Bioinformatics
Drug Discovery
Life Sciences
Protein Chemistry
In Vitro
Biochemistry
Chemistry
Molecular Biology
Drug Design
Leadership
Cross Functional Team Leadership
Lifesciences
Strategy
Validation
Animal Models
Cell Biology
Research
R&D
Pharmaceutical Industry
Start Ups
Cell Culture
Technology Transfer
In Vivo
Training
Biomarker Discovery
Business Development
Analysis
Pcr
Elisa
Access
C#
Computational Chemistry
Teaching
Project Management
Analytics
Signal Processing
Css
Testing
Microsoft Sql Server
Digital Imaging
Microsoft Excel
Medical Imaging
Management
Science
Computational Biology
Research and Development
Consulting
Interests:
Children
Languages:
Hebrew
English
Dutch
Sharon Shechter Photo 2

Sharon Shechter

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Publications

Us Patents

Nuclear Transport Modulators And Uses Thereof

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US Patent:
20110275607, Nov 10, 2011
Filed:
Mar 5, 2011
Appl. No.:
13/041377
Inventors:
Sharon Shacham - Newton MA, US
Michael Kauffman - Newton MA, US
Vincent P. Sandanayaka - Northboro MA, US
Sharon Shechter - Andover MA, US
Assignee:
KARYOPHARM THERAPEUTICS, INC. - Newton MA
International Classification:
A61K 31/4196
C07D 401/12
A61K 31/4439
C07D 403/12
C07D 417/04
A61K 31/427
C07D 401/14
A61K 31/444
A61P 35/00
A61P 29/00
A61P 11/00
A61P 1/16
A61P 13/12
A61P 31/12
C07D 249/08
US Classification:
5142102, 5482684, 514383, 5462724, 514340, 5482666, 5482674, 548202, 514365, 546256, 514333
Abstract:
The invention generally relates to the field of nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to new substituted-heterocyclic azole compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity such as in treating cancer and other neoplastic disorders, inflammatory diseases, disorders of abnormal tissue growth and fibrosis including cardiomyopathy, pulmonary fibrosis, hepatic fibrosis, glomerulonephritis, and other renal disorders, and for the treatment of viral infections (both acute and chronic).

Olefin Containing Nuclear Transport Modulators And Uses Thereof

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US Patent:
20120258986, Oct 11, 2012
Filed:
Jan 16, 2012
Appl. No.:
13/350864
Inventors:
Vincent P. Sandanayaka - Northboro MA, US
Sharon Shacham - Newton MA, US
Sharon Shechter - Andover MA, US
Dilara McCauley - Natick MA, US
Assignee:
KARYOPHARM THERAPEUTICS, INC. - Natick MA
International Classification:
C07D 413/06
C07D 413/14
A61K 31/4439
C07D 401/06
C07D 249/08
A61P 9/10
A61P 35/00
A61P 31/12
A61P 29/00
A61P 19/02
A61P 17/00
A61P 17/06
A61K 31/4245
A61K 31/4196
US Classification:
514340, 548143, 514364, 5462691, 5462724, 5482694, 514383
Abstract:
The invention generally relates to the field of nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to new substituted-heterocyclic azole compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity such as in treating cancer and other neoplastic disorders, inflammatory diseases, disorders of abnormal tissue growth and fibrosis including cardiomyopathy, pulmonary fibrosis, hepatic fibrosis, glomerulonephritis, and other renal disorders, and for the treatment of viral infections (both acute and chronic).

Nuclear Transport Modulators And Uses Thereof

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US Patent:
20130317031, Nov 28, 2013
Filed:
May 9, 2013
Appl. No.:
13/891044
Inventors:
Sharon Shechter - Andover MA, US
Sharon Shacham - Newton MA, US
Dilara McCauley - Cambridge MA, US
Erkan Baloglu - Stoneham MA, US
Assignee:
Karyopharm Therapeutics Inc. - Natick MA
International Classification:
C07D 249/08
A61K 31/497
A61K 31/454
A61K 45/06
C07D 403/12
C07D 401/12
C07D 413/12
A61K 31/5377
A61K 31/4196
US Classification:
5142362, 51425505, 514326, 514383, 544132, 544405, 546210, 5482666, 5482676
Abstract:
The present invention relates to compounds of formula I:and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the compounds of formula I, and methods of using said compounds, salts and compositions in the treatment of various disorders associated with CRM1 activity.

Nuclear Transport Modulators And Uses Thereof

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US Patent:
20220177445, Jun 9, 2022
Filed:
Aug 23, 2021
Appl. No.:
17/409150
Inventors:
- Newton MA, US
Sharon Shacham - Newton MA, US
Dilara McCauley - Arlington MA, US
Trinayan Kashyap - Framingham MA, US
William Senapedis - Millis MA, US
Yosef Landesman - Brookline MA, US
Gali Golan - Mesilat Zion, IL
Ori Kalid - Pardes Hanna, IL
Sharon Shechter - Andover MA, US
International Classification:
C07D 401/06
C07D 249/08
C07D 403/06
C07D 405/06
C07D 413/06
C07D 417/06
Abstract:
The present invention relates to compounds of formula I:and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the compounds of formula I or their pharmaceutically acceptable salts, and methods of using said compounds, salts and compositions in the treatment of various disorders associated with CRM1 activity.

Compounds For The Prevention And Treatment Of Diseases And The Use Thereof

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US Patent:
20230132265, Apr 27, 2023
Filed:
Jun 8, 2022
Appl. No.:
17/835363
Inventors:
- Norcross GA, US
Peter G. Traber - Alpharetta GA, US
Raphael Nir - Needham MA, US
Sharon Shechter - Andover MA, US
Joseph M. Johnson - Arlington MA, US
Ryan George - Framingham MA, US
International Classification:
A61K 31/7056
A61P 1/16
A61P 9/00
A61P 13/12
A61K 45/06
C07H 17/00
C07H 17/02
C07H 99/00
Abstract:
Aspects of the invention relate to novel synthetic compounds having binding affinity with galectin proteins.

Compounds For The Prevention And Treatment Of Medical Disorders And Uses Thereof

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US Patent:
20230116370, Apr 13, 2023
Filed:
Jul 8, 2022
Appl. No.:
17/861023
Inventors:
- Norcross GA, US
Eliezer ZOMER - Newton MA, US
Peter G. TRABER - Gladwyne PA, US
Joseph M. JOHNSON - Arlington MA, US
Ryan GEORGE - Framingham MA, US
Sharon SHECHTER - Andover MA, US
International Classification:
A61K 31/519
A61P 3/10
A61K 45/06
C07D 487/04
Abstract:
Aspects of the invention relate to compounds, pharmaceutical compositions, methods for the manufacturing of compounds and methods for treatment of various disorders mediated at least in part by one or more galectins.

Substituted Benzofuranyl And Benzoxazolyl Compounds And Uses Thereof

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US Patent:
20210403459, Dec 30, 2021
Filed:
Mar 18, 2021
Appl. No.:
17/205797
Inventors:
- Newton MA, US
Sharon Shacham - Newton MA, US
William Senapedis - Millis MA, US
Dilara McCauley - Arlington MA, US
Yosef Landesman - Brookline MA, US
Gali Golan - Mesilat Zion, IL
Ori Kalid - Pardes Hanna, IL
Sharon Shechter - Andover MA, US
International Classification:
C07D 405/14
C07D 405/12
C07D 409/14
C07D 413/12
C07D 417/12
C07D 307/81
C07D 413/14
C07D 491/048
C07D 491/08
Abstract:
The invention generally relates to substituted benzofuranyl and substituted benzoxazolyl compounds, and more particularly to a compound represented by Structural Formula A:or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula A, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.

Nuclear Transport Modulators And Uses Thereof

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US Patent:
20210251968, Aug 19, 2021
Filed:
Feb 19, 2021
Appl. No.:
17/179512
Inventors:
- Cambridge MA, US
Sharon Shechter - Andover MA, US
Sharon Shacham - Newton MA, US
Dilara McCauley - Arlington MA, US
Erkan Baloglu - Stoneham MA, US
Assignee:
Biogen MA Inc. - Cambridge MA
International Classification:
A61K 31/4196
C07D 403/12
C07D 413/12
C07D 249/08
A61K 31/454
A61K 31/497
A61K 31/5377
A61K 45/06
C07D 401/12
C07D 401/10
Abstract:
Compounds of formula I:and pharmaceutically acceptable salts, solvates, or hydrates thereof, pharmaceutical compositions comprising the compounds of formula I, and methods of making and using the compounds, salts, solvates, or hydrates and the compositions in the treatment of various disorders associated with CRM1 activity.
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Sharon B Shechter from Andover, MA, age ~54 Get Report