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Serguei A Soukharev

from Melbourne, FL
Age ~59

Serguei Soukharev Phones & Addresses

  • Melbourne, FL
  • Wheeling, IL
  • Northbrook, IL
  • 7421 Mahaska Dr, Derwood, MD 20855 (301) 948-1581
  • Bethesda, MD
  • Gaithersburg, MD
  • Detroit, MI
  • 7421 Mahaska Dr, Derwood, MD 20855

Resumes

Resumes

Serguei Soukharev Photo 1

Senior Analyst

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Work:
Scotiabank
Senior Analyst
Education:
Peoples’ Friendship University of Russia 1972 - 1978
Masters, Civil Engineering
Serguei Soukharev Photo 2

Gerente De Mantenimiento

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Work:
Ministerio De Transportes Y Telecomunicaciones Sep 2002 - Sep 2013
Inspector Dgac

Flexair Sac Sep 2002 - Sep 2013
Gerente De Mantenimiento

Publications

Us Patents

Fluorescent Substrates For Detecting Organophosphatase Enzyme Activity

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US Patent:
7374900, May 20, 2008
Filed:
Mar 16, 2004
Appl. No.:
10/553650
Inventors:
Serguei Soukharev - Derwood MD, US
David Hammond - Laytonsville MD, US
Assignee:
The American National Red Cross - Rockville MD
International Classification:
C12Q 1/42
C07F 9/12
US Classification:
435 21, 549220
Abstract:
Disclosed are compounds of the formula (I): wherein R, R, R, R, and Rare selected from the group consisting of H and groups or atoms other than H, and Rand Rare halo or hydrogen; X, X, and Xare independently O or S; provided that Rand Rare not simultaneously H, when all of X, X, and Xare O; and of the formula (II) wherein R-Rare selected from the group consisting of H and groups or atoms other than H; X-Xare independently O or S; n and m are 0 or 1 but m and n cannot be 0 simultaneously; R-Rcan be H or any substituent so long as the compound of formula II upon hydrolysis provides a fluorescent compound. These compounds are useful as substrates with high specificity for organophosphatase particularly human paraoxonase and bacterial organophosphorus hydrolase. Also disclosed is a method for detecting and/or measuring the paraoxonase activity in a fluid comprising contacting the fluid with a fluorescent substrate and measuring the fluorescence of the fluorescent product formed.

Plasma Protein-Binding Ligands

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US Patent:
20080160501, Jul 3, 2008
Filed:
May 2, 2007
Appl. No.:
11/797318
Inventors:
David J. Hammond - Laytonsville MD, US
Serguei Soukharev - Derwood MD, US
Assignee:
The American National Red Cross - Falls Church VA
International Classification:
C12Q 1/00
US Classification:
435 4
Abstract:
The invention provides an isolated or purified peptide that binds at least one plasma protein. In one embodiment, the isolated or purified peptide binds to fibrinogen, comprises no more than 10 amino acids, and comprises an amino acid sequence Xaa-Xaa-Xaa-Xaa-Xaa, and amino acid sequence Gly-Xaa-Arg-Xaa, or an amino acid sequence selected from specific amino acid sequences provided herein. Alternatively, the isolated or purified protein binds to α1 proteinase inhibitor and/or a protein complex comprising Apo-A1 lipoprotein and paraoxonase. The peptide comprises no more than 10 amino acids and comprises an amino acid sequence Xaa-Xaa-His-Xaa-Xaa, and amino acid sequence His-Xaa-Xaa-Xaa-Xaa-Xaa, or an amino acid sequence selected from specific amino acid sequence provided herein. In addition, the invention provides isolated or purified peptide that binds to von Willebrand Factor. The peptide comprises an amino acid sequence Xaa-Xaa-Xaa, an amino acid sequence Tyr-Leu-Xaa-Xaa-Xaa-Thr, or an amino acid sequence selected from specific amino acid sequences provided herein.

Fluorescent Substrates For Detecting Organophosphatase Enzyme Activity

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US Patent:
20100255521, Oct 7, 2010
Filed:
Jan 3, 2007
Appl. No.:
11/648679
Inventors:
Serguei Soukharev - Derwood MD, US
David Hammond - Laytonsville MD, US
International Classification:
C12Q 1/42
C07F 9/12
US Classification:
435 21, 549220
Abstract:
Disclosed are compounds of the formula (I): wherein R, R, R, R, and Rare selected from the group consisting of H and groups or atoms other than H, and Rand Rare halo or hydrogen; X, X, and Xare independently O or S; provided that Rand Rare not simultaneously H, when all of X, X, and Xare O; and of the formula (II) wherein R-Rare selected from the group consisting of H and groups or atoms other than H; X-Xare independently O or S; n and m are 0 or 1 but m and n cannot be 0 simultaneously; R-Rcan be H or any substituent so long as the compound of formula II upon hydrolysis provides a fluorescent compound. These compounds are useful as substrates with high specificity for organophosphatase particularly human paraoxonase and bacterial organophosphorus hydrolase. Also disclosed is a method for detecting and/or measuring the paraoxonase activity in a fluid comprising contacting the fluid with a fluorescent substrate and measuring the fluorescence of the fluorescent product formed.
Serguei A Soukharev from Melbourne, FL, age ~59 Get Report