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Sean F Covalla

from Thetford Center, VT
Age ~43
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Related to:
Emma S Cushman, 35Elizabeth C CovallaVincent P Clark, 77Carmen CalabroFrances CalabroEdward Sylvia, 68
Connected to:
Lois E Covall, 109Karen L Covalt, 81Melissa Covalt, 50Tiffanie J Covalt, 35James P Covan, 43John B Covan, 45John N Covanes, 78Aaron Covany, 41Joel J Covar, 65Alan Covarrubias, 31

Sean Covalla Phones & Addresses

  • 2137 Academy Rd, Thetford Ctr, VT 05075
  • Thetford Center, VT
  • Lebanon, NH
  • Amherst, MA
  • 265 Colchester Ave, Burlington, VT 05401 (802) 859-9325
  • 77 Rose St, Burlington, VT 05401 (802) 658-3227
  • Belmont, VT
  • Thetford Ctr, VT

Work

Company: Mascoma corp. Dec 2007 Position: Research associate ii

Education

Degree: B.A. School / High School: University of Vermont 1999 to 2003 Specialities: Biology

Skills

Microbiology • Fermentation • Biochemistry • Biotechnology • Biofuels • Cell Culture • Protein Purification • Laboratory • Molecular Biology • Lifesciences • Pcr • Protein Expression • Research • Microscopy • Cell • Life Sciences • Cell Based Assays

Emails

i***[email protected]

Industries

Biotechnology

Resumes

Resumes

Sean Covalla Photo 1

Research Associate Iii

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Location:
2137 Academy Rd, Thetford Center, VT 05075
Industry:
Biotechnology
Work:
Mascoma Corp. since Dec 2007
Research Associate II
University of Massachusetts Amherst Apr 2005 - Nov 2007
Research Fellow
Education:
University of Vermont 1999 - 2003
B.A., Biology
Skills:
Microbiology
Fermentation
Biochemistry
Biotechnology
Biofuels
Cell Culture
Protein Purification
Laboratory
Molecular Biology
Lifesciences
Pcr
Protein Expression
Research
Microscopy
Cell
Life Sciences
Cell Based Assays

Publications

Us Patents

Heterologous Expression Of Urease In Anaerobic, Thermophilic Hosts

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US Patent:
20130171708, Jul 4, 2013
Filed:
Dec 6, 2010
Appl. No.:
13/514519
Inventors:
Sean Covalla - Lebanon NH, US
International Classification:
C12N 15/52
C12P 7/10
US Classification:
435165, 4352523
Abstract:
The invention is directed to the heterologous expression of urease in anaerobic thermophilic hosts, such as , and other related genera. For example, the anaerobic thermophilic host can be . The host cells express the catalytic subunits of the urease enzyme together with the accessory proteins ureDEFG that facilitate protein folding and nickel activation. The invention further relates to the use of urea as a nitrogen source in the growth of microorganisms involved in consolidated bioprocessing systems.

Acetate Toxicity Tolerance In Recombinant Microbial Host Cells

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US Patent:
20210155944, May 27, 2021
Filed:
Sep 18, 2018
Appl. No.:
16/648625
Inventors:
- Budapest, HU
Sean Covalla - Thetford Center VT, US
Allan Froehlich - Norwich VT, US
International Classification:
C12N 15/81
C12N 9/92
C12N 9/12
C12N 9/90
C12N 9/10
C12N 9/04
C07K 14/395
C12N 9/00
C12P 7/06
Abstract:
Acetate is a potent microbial inhibitor which can affect the performance of yeast in ethanolic fermentation. The present disclosure provides a recombinant microbial host cell having (i) a first genetic modification for increasing the activity of one or more proteins that function in a first metabolic pathway to convert acetate into an alcohol in the microbial host cell; (ii) a second genetic modification for increasing the activity of one or more proteins that function in a second metabolic pathway to import glycerol in the recombinant microbial host cell (iii) a third genetic modification for increasing the activity of one or more proteins that function in a third metabolic pathway to convert a C5 carbohydrate into ethanol in the microbial host cell. The recombinant microbial host cell comprises and natively expresses native proteins that function in a fourth native metabolic pathway to produce glycerol in the microbial host cell.

Mutations In Iron-Sulfur Cluster Proteins That Improve Xylose Utilization

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US Patent:
20200115697, Apr 16, 2020
Filed:
Sep 18, 2019
Appl. No.:
16/575350
Inventors:
- Budapest, HU
Brooks Henningsen - Lebanon NH, US
Sean Covalla - Thetford Center VT, US
International Classification:
C12N 9/92
C07K 14/395
C12P 7/06
Abstract:
There is provided an engineered host cells comprising (a) one or more mutations in one or more endogenous genes encoding a protein associated with iron metabolism; and (b) at least one gene encoding a polypeptide having xylose isomerase activity, and methods of their use thereof.

Support For Bottles

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US Patent:
20180339295, Nov 29, 2018
Filed:
May 26, 2017
Appl. No.:
15/606591
Inventors:
- Rexdale, CA
Sean COVALLA - Thetford Center VT, US
International Classification:
B01L 9/00
B65D 23/00
B01L 3/00
Abstract:
A support that comprises a plate having a first side and a second side opposed to the first side. The plate has a sample section including bottle-receiving members defined in the first side and configured for holding the bottles in a fixed position relative to the plate, and first conduit-receiving openings extending from the first side to the second side for receiving conduits extending from the bottles. The plate has a manifold section including second conduit-receiving openings extending from the first side to the second side for receiving the conduits. The plate has a channel section including channels defined in the second side and extending between the first conduit-receiving openings and the second conduit-receiving openings for receiving the conduits therein. The support may be used for example on a shaker. A method for retaining bottles and conduits connected to the bottles is also discussed.

Mutations In Iron-Sulfur Cluster Proteins That Improve Xylose Utilization

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US Patent:
20180251750, Sep 6, 2018
Filed:
Jan 31, 2018
Appl. No.:
15/884449
Inventors:
- Budapest, HU
Brooks Henningsen - Lebanon NH, US
Sean Covalla - Thetford Center VT, US
International Classification:
C12N 9/92
C07K 14/395
C12P 7/06
Abstract:
There is provided an engineered host cells comprising (a) one or more mutations in one or more endogenous genes encoding a protein associated with iron metabolism; and (b) at least one gene encoding a polypeptide having xylose isomerase activity, and methods of their use thereof.

Mutations In Iron-Sulfur Cluster Proteins That Improve Xylose Utilization

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US Patent:
20160040153, Feb 11, 2016
Filed:
Aug 10, 2015
Appl. No.:
14/821955
Inventors:
- Budapest, HU
Brooks Henningsen - Lebanon NH, US
Sean Covalla - Thetford Center VT, US
International Classification:
C12N 9/92
C12P 7/06
Abstract:
There is provided an engineered host cells comprising (a) one or more mutations in one or more endogenous genes encoding a protein associated with iron metabolism; and (b) at least one gene encoding a polypeptide having xylose isomerase activity, and methods of their use thereof.
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Sean F Covalla from Thetford Center, VT, age ~43 Get Report