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Richard J Varsolona

from Scotch Plains, NJ
Age ~60

Richard Varsolona Phones & Addresses

  • 1973 Inverness Dr, Scotch Plains, NJ 07076 (908) 233-7368
  • Roselle, NJ
  • Rahway, NJ
  • Elizabeth, NJ

Resumes

Resumes

Richard Varsolona Photo 1

Sr. Principle Scientist At Wyeth

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Position:
Sr. Principle Scientist at Wyeth, Senior Principal Scientist II at Pfizer Pharmaceuticals
Location:
Greater New York City Area
Industry:
Pharmaceuticals
Work:
Wyeth
Sr. Principle Scientist

Pfizer Pharmaceuticals since 2007
Senior Principal Scientist II

BIPI 2001 - 2007
Senior Principal Scientist

merck 1990 - 2001
scientist
Richard Varsolona Photo 2

Senior Principal Scientist Ii At Wyeth

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Position:
Senior Principal Scientist II at Wyeth, senior Principal Scientist II at Pfizer Pharmaceuticals, Senior Principal Scientist II at Pfizer Global R&D, senior prinicpal scientist II at Pfizer, Senior Principal Scientist II at Wyeth (Now Part of Pfizer), Senior Principal Scientist II at Wyeth Research
Location:
Greater New York City Area
Industry:
Pharmaceuticals
Work:
Wyeth
Senior Principal Scientist II

Pfizer Pharmaceuticals since 2007
senior Principal Scientist II

Pfizer Global R&D since 2007
Senior Principal Scientist II

Pfizer since 2007
senior prinicpal scientist II

Wyeth (Now Part of Pfizer) since 2007
Senior Principal Scientist II

Publications

Us Patents

Thermodynamically Stable Crystal Form Of 4€³-Deoxy-4€³-Epi-Methylamino Avermectin B1A/B1B Benzoic Acid Salt And Processes For Its Preparation

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US Patent:
6486195, Nov 26, 2002
Filed:
Jan 20, 1995
Appl. No.:
08/376318
Inventors:
Raymond Cvetovich - Scotch Plains NJ
James A. McCauley - Belle Mead NJ
Richard Demchak - Langhorne PA
Richard J. Varsolona - Scotch Plains NJ
Assignee:
Merck Co., Inc. - Rahway NJ
International Classification:
A61K 31352
US Classification:
514450, 549264
Abstract:
The most thermodynamically stable crystalline form of the benzoic acid salt of 4″-deoxy-4″-epi-methylamino avermectin B1a/B1b as the hemihydrate is obtained by crystallization from organic solvents containing a controlled amount of water.

Process For Making Hiv Protease Inhibitors

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US Patent:
5618939, Apr 8, 1997
Filed:
Jun 7, 1995
Appl. No.:
8/474926
Inventors:
David Askin - Warren NJ
Paul Reider - Westfield NJ
Kai Rossen - Westfield NJ
Richard J. Varsolona - Scotch Plains NJ
Ralph P. Volante - Cranbury NJ
Kenneth M. Wells - Somerville NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07D40906
C07D40914
C07D40506
C07D24104
US Classification:
544368
Abstract:
A process is disclosed for making a chiral compound of the formula ##STR1## comprising reacting an epoxide compound of the formula ##STR2## and an amide of the formula ##STR3## in the presence of a strong base at a low temperature.

Hiv Protease Inhibitor

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US Patent:
6071916, Jun 6, 2000
Filed:
May 28, 1998
Appl. No.:
9/086021
Inventors:
David Askin - Warren NJ
Robert M. Purick - Edison NJ
R. Scott Hoerrner - Westfield NJ
Paul Reider - Westfield NJ
Richard J. Varsolona - Scotch Plains NJ
Ralph P. Volante - Cranbury NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 31495
C07D40506
US Classification:
514253
Abstract:
This invention relates to a sulfate salt of an HIV protease inhibitor, Compound A, of formula: ##STR1## Compound A is useful in the treatment of AIDS, ARC or HIV infection in adults and children. Processes for making the sulfate salt of Compound A are also disclosed.

Polymorphic Forms Of A Growth Hormone Secretagogue

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US Patent:
5767124, Jun 16, 1998
Filed:
Oct 23, 1996
Appl. No.:
8/736170
Inventors:
Jerome P. Draper - Elkins Park PA
Michael J. Kaufman - New Hope PA
David C. Dubost - Collegeville PA
James A. McCauley - Belle Mead NJ
Jennifer L. Vandrilla - Cranford NJ
Richard J. Varsolona - Scotch Plains NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 31445
C07D40102
US Classification:
514278
Abstract:
This invention is concerned with polymorphic forms of the compound N-1(R)-(1,2-dihydro-1-methanesulfonylspiro3H-indole-3,4'-piperdin!-1'-y l)carbonyl!-2-(phenylmethyloxy)ethyl!-2-amino-2-methylpropanamide methanesulfonate which is a growth hormone secretagogue that is useful in food animals to promote their growth thereby rendering the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, and to treat medical conditions which are improved by the anabolic effects of growth hormone. The instant polymorphic forms have advantages over the other known forms of N-1(R)-(1,2-dihydro-1-methanesulfonylspiro3H-indole-3,4'-piperdin!-1'-y l)carbonyl!-2-(phenylmethyloxy)-ethyl!-2-amino-2-methylpropanamide methanesulfonate in terms of thermodynamic stability and suitability for inclusion in pharmaceutical formulations. The present invention is also concerned with processes for preparing these polymorphic forms, pharmaceutical formulations comprising these polymorphic forms as active ingredients and the use of the polymorphic form of the compound and their formulations in the treatment of certain disorders.

New Finasteride Processes

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US Patent:
5468860, Nov 21, 1995
Filed:
Jan 29, 1993
Appl. No.:
8/010734
Inventors:
Ulf H. Dolling - Westfield NJ
James A. McCauley - Belle Mead NJ
Richard J. Varsolona - Scotch Plains NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07D22104
US Classification:
546 77
Abstract:
Disclosed is a new process for producing finasteride which involves reacting the magnesium halide salt of 17. beta. B-carboalkoxy-4-aza-5. alpha. -androst-1-en-3-one with t-butylamino magnesium halide, present in at least a 2:1 molar ratio to the ester, formed from t-butyl amine and an aliphatic/aryl magnesium halide at ambient temperature in an inert organic solvent under an inert atmosphere followed by heating and recovering said product finasteride. Also disclosed are two polymorphic crystalline Forms I and II of finasteride, and methods of their production.

Process For Making Hiv Protease Inhibitors

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US Patent:
5693803, Dec 2, 1997
Filed:
Jun 7, 1995
Appl. No.:
8/474800
Inventors:
David Askin - Warren NJ
Kai Rossen - Westfield NJ
Paul Reider - Westfield NJ
Richard J. Varsolona - Scotch Plains NJ
Ralph P. Volante - Cranbury NJ
Kenneth M. Wells - Somerville NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07D40506
C07D40514
US Classification:
544364
Abstract:
Intermediates of structural formula ##STR1## can be made by reacting a primary or secondary amine with glycosidol or an activated derivative thereof. The process and intermediates are useful for synthesizing HIV protease inhibitor compounds.

Pyrazinone Thrombin Inhibitors

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US Patent:
5866573, Feb 2, 1999
Filed:
Apr 21, 1997
Appl. No.:
8/837682
Inventors:
Philip E.. Sanderson - Philadelphia PA
Terry A.. Lyle - Lederach PA
Bruce D. Dorsey - Maple Glen PA
Richard J. Varsolona - Scotch Plains NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 31495
C07D40112
C07D40312
C07D41312
US Classification:
5142358
Abstract:
Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: ##STR1## for example: ##STR2##.

Process For Making Hiv Protese Inhibitors

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US Patent:
5861512, Jan 19, 1999
Filed:
Sep 16, 1997
Appl. No.:
8/929970
Inventors:
David Askin - Warren NJ
Kai Rossen - Westfield NJ
Paul Reider - Westfield NJ
Richard J. Varsolona - Scotch Plains NJ
Ralph P. Volante - Cranbury NJ
Kenneth M. Wells - Somerville NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07D24104
US Classification:
544390
Abstract:
Intermediates of structural formula ##STR1## can be made by reacting a primary or secondary amine with glycosidol or an activated derivative thereof. The process and intermediates are useful for synthesizing HIV protease inhibitor compounds.
Richard J Varsolona from Scotch Plains, NJ, age ~60 Get Report