Inventors:
Barry C. Buckland - Westfield NJ
Neal C. Connors - Fanwood NJ
Michel M. Chartrain - Westfield NJ
Francis P. Gailliot - Cranford NJ
Randolph L. Greasham - Mountainside NJ
Barbara Jackey - Bloomfield NJ
Brian Heimbuch - North Brunswick NJ
Chanyong Lee - Princeton NJ
Roger C. Olewinski - Milltown NJ
F. Edward Roberts - Princeton NJ
Paul J. Reider - Westfield NJ
Thomas R. Verhoeven - Cranford NJ
Chris H. Senanayake - North Brunswick NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C12P 1302
C12P 722
C12P 4100
Abstract:
A process is disclosed that bioconverts indene to (1S)-amino-(2R)-indanol substantially free of any of its stereoisomers, by the action of a strain of P. putida or Rhodococcus sp. , followed by various chemical step(s), e. g. , chiral specific crystallization, treatment with strong acid in the presence of acetonitrile.