Inventors:
Xin Wei Wang - Rockville MD, US
Curtis C. Harris - Garrett Park MD, US
Jill D. Coursen - Boston MA, US
Qimin Zhan - Pittsburgh PA, US
Assignee:
The United States of America as represented by the Department of Health and Human Sevices - Washington DC
International Classification:
A61K 38/00
A61K 38/04
C07K 7/00
US Classification:
514 17, 514 12, 514 13, 514 15, 514 16, 530329, 530324, 530326, 530327, 530328
Abstract:
The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA base-damaging agent by administration of novel inhibitors of GADD45 polypeptide activity. The invention further provides polypeptides which interfere with the ability of Cdc2/cyclin B1 complexes to cause a pause at the G2/M stage of the cell cycle in response to GADD45, and nucleic acids which encode such polypeptides.