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Qimin Zhan

from Pittsburgh, PA
Age ~65

Qimin Zhan Phones & Addresses

  • 5830 Elwood St, Pittsburgh, PA 15232 (412) 665-0351
  • 335 Side Dr, Gaithersburg, MD 20878 (301) 947-8736
  • 7 Seurat Ln, Gaithersburg, MD 20878 (301) 947-8736
  • North Potomac, MD
  • Rockville, MD
  • Bethesda, MD
  • 5830 Elwood St APT 1, Pittsburgh, PA 15232 (610) 209-2037

Work

Position: Service Occupations

Publications

Us Patents

Methods For Identifying Inhibitors Of Gadd45 Polypeptide Activity And Inhibitors Of Such Activity

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US Patent:
7005419, Feb 28, 2006
Filed:
Jun 20, 2003
Appl. No.:
10/600158
Inventors:
Xin Wei Wang - Rockville MD, US
Curtis C. Harris - Garrett Park MD, US
Jill D. Coursen - Boston MA, US
Qimin Zhan - Pittsburgh PA, US
Assignee:
The United States of America as represented by the Department of Health and Human Services - Washington DC
International Classification:
A61K 38/00
US Classification:
514 12, 514 2, 530329, 435 6, 435 71, 424 851
Abstract:
The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA base-damaging agent by administration of novel inhibitors of GADD45 polypeptide activity. The invention further provides polypeptides which interfere with the ability of Cdc2/cyclin B1 complexes to cause a pause at the G2/M stage of the cell cycle in response to GADD45, and nucleic acids which encode such polypeptides.

Methods Of Identifying Inhibitors Of Gadd45 Polypeptide Activity, And Inhibitors Of Such Activity

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US Patent:
7125850, Oct 24, 2006
Filed:
Dec 7, 2005
Appl. No.:
11/297160
Inventors:
Xin Wei Wang - Rockville MD, US
Curtis C. Harris - Garrett Park MD, US
Jill D. Coursen - Boston MA, US
Qimin Zhan - Pittsburgh PA, US
Assignee:
The United States of America as represented by the Department of Health and Human Sevices - Washington DC
International Classification:
A61K 38/00
A61K 38/04
C07K 7/00
US Classification:
514 17, 514 12, 514 13, 514 15, 514 16, 530329, 530324, 530326, 530327, 530328
Abstract:
The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA base-damaging agent by administration of novel inhibitors of GADD45 polypeptide activity. The invention further provides polypeptides which interfere with the ability of Cdc2/cyclin B1 complexes to cause a pause at the G2/M stage of the cell cycle in response to GADD45, and nucleic acids which encode such polypeptides.

Method Of Identifying Inhibitors Of Gadd45 Polypeptide Activity, And Inhibitors Of Such Activity

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US Patent:
7438892, Oct 21, 2008
Filed:
Aug 17, 2006
Appl. No.:
11/506947
Inventors:
Xin Wei Wang - Rockville MD, US
Curtis C. Harris - Garrett Park MD, US
Albert J. Fornace - Bethesda MD, US
Jill D. Coursen - Boston MA, US
Qimin Zhan - Pittsburgh PA, US
Assignee:
The United States of Americas as represented by the Secretary of the Department of Health and Human Services - Washington DC
International Classification:
A61K 49/00
G01N 33/53
G01N 33/574
US Classification:
424 91, 435 71, 435 723
Abstract:
The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA base-damaging agent by administration of novel inhibitors of GADD45 polypeptide activity. The invention further provides polypeptides which interfere with the ability of Cdc2/cyclin B1 complexes to cause a pause at the G2/M stage of the cell cycle in response to GADD45, and nucleic acids which encode such polypeptides.

Methods For Identifying Inhibitors Of Gadd45 Polypeptide Activity, And Inhibitors Of Such Activity

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US Patent:
6613318, Sep 2, 2003
Filed:
Mar 24, 2000
Appl. No.:
09/534811
Inventors:
Xin Wei Wang - Rockville MD
Curtis C. Harris - Garrett Park MD
Jill D. Coursen - Boston MA
Qimin Zhan - Pittsburgh PA
Assignee:
The United States of America as represented by the Department of Health and Human Services - Washington DC
International Classification:
A61K 4500
US Classification:
424 851, 435 6, 435 71, 514 12, 530350, 530386, 5303881
Abstract:
The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA base-damaging agent by administration of novel inhibitors of GADD45 polypeptide activity. The invention further provides polypeptides which interfere with the ability of Cdc2/cyclin B1 complexes to cause a pause at the G2/M stage of the cell cycle in response to GADD45, and nucleic acids which encode such polypeptides.
Qimin Zhan from Pittsburgh, PA, age ~65 Get Report