US Patent:
20070264319, Nov 15, 2007
Inventors:
David Lebo - Warminster PA, US
Juny Lee - Monmouth Junction NJ, US
Je Phil Ryoo - Princeton NJ, US
Oliver Toigo - Churchville PA, US
Francis Cupo - Yardley PA, US
International Classification:
A61K 31/44
A61K 47/00
A61K 47/14
A61K 47/44
A61K 9/70
A61P 1/08
US Classification:
424449000, 514304000, 514772700, 514782000, 514785000
Abstract:
A transdermal antiemesis system, preferably in the form of a drug-in-adhesive matrix patch, is disclosed comprising an effective antiemesis amount of a selective serotonin (5-HT) receptor antagonist as an antiemetic incorporated in a skin adhesive composition containing at least one permeation enhancer and a water-insoluble pressure-sensitive adhesive. A preferred antiemetic is granisetron base. The transdermal antiemesis system of this invention provides controlled release of the active antiemetic ingredient from the skin-contacting adhesive formulation of a transderrnal patch, and maintains a sustained transdermal delivery of the antiemetic.