Nancie A Senko

54687748, Nov 21, 1995

Mar 14, 1995

8/403318

Guy A. Schiehser - Yardley PA
Craig E. Caufield - Plainsboro NJ
Nancie A. Senko - Plainsboro NJ
Gregory F. VonBurg - Princeton NJ

American Home Products Corporation - Madison NJ

A61K 3134
C07D30746

514471

There are disclosed compounds of the formula: ##STR1## wherein X is O; R. sup. 1 and R. sup. 2 are each, independently, hydrogen, C. sub. 1 -C. sub. 10 alkyl, C. sub. 3 -C. sub. 20 cycloalkyl, phenylloweralkyl, or substituted phenylloweralkyl substituted by halo, lower alkyl, lower alkoxy, halo lower alkyl, amino, monoloweralkylamino, diloweralkylamino or sulfonamido; A is O, S, NR, or a chemical bond; R, if present, is hydrogen or loweralkyl; m is 0-15; n is 3-12; p is 0-15, where m+p=2-15; and the pharmacologically acceptable salts thereof. Also disclosed is a method for treating immunoimmflammatory conditions in mammals which comprises administering to a mammal so afflicted an effective amount of a compound having the formula above wherein X, R. sup. 1, R. sup. 2, A, R, if present, m and p are as listed above and n=3-12 and m+p=2-15.

53669932, Nov 22, 1994

Jun 3, 1993

8/071627

Guy A. Schiehser - Yardley PA
Craig E. Caufield - Plainsboro NJ
Nancie A. Senko - Plainsboro NJ
Gregory F. VonBurg - Princeton NJ

American Home Products Corporation - Madison NJ

C07D33316
A61K 3138

514445

There are disclosed compounds of the formula: ##STR1## wherein X is O, S or NR; R is hydrogen or lower alkyl; R. sup. 1 and R. sup. 2 are each, independently, hydrogen, C. sub. 1 -C. sub. 10 alkyl, C. sub. 3 -C. sub. 20 cycloalkyl, phenylloweralkyl, or substituted phenylloweralkyl substituted by halo, lower alkyl, lower alkoxy, halo lower alkyl, amino, monoloweralkylamino, diloweralkylamino or sulfonamido; A is O, S, NR, or a chemical bond; m is 0-15; n is 0-20; p is 0-15, where m+p. ltoreq. 15; and the pharmacologically acceptable salts thereof, which by virtue of their ability to inhibit PLA. sub. 2, are of use as antiinflammatory agents and there is also disclosed a method for the treatment of immunoinflammatory conditions, such as allergy, anaphylaxis, asthma and inflammation in mammals, as well as in the modulation of PAF-mediated biological processes, such as embryonic implantation, thus making the compounds useful as antifertility agents.

54201535, May 30, 1995

Sep 8, 1994

8/303304

Guy A. Schiehser - Yardley PA
Craig E. Caufield - Plainsboro NJ
Nancie A. Senko - Plainsboro NJ
Gregory F. VonBurg - Princeton NJ

American Home Products Corporation - Madison NJ

A61K 3140
C07D20724

514423

There are disclosed compounds of the formula: ##STR1## wherein X is NR; R is hydrogen or lower alkyl; R. sup. 1 and R. sup. 2 are each, independently, hydrogen, C. sub. 1 -C. sub. 10 alkyl, C. sub. 3 -C. sub. 20 cycloalkyl, phenylloweralkyl, or substituted phenylloweralkyl substituted by halo, lower alkyl, lower alkoxy, halo lower alkyl, amino, monoloweralkylamino, diloweralkylamino or sulfonamido; A is O, S, NR, or a chemical bond; m is 0-15; n is 0-20; p is 0-15, where m+p. ltoreq. 15; and the pharmacologically acceptable salts thereof, which by virtue of their ability to inhibit PLA. sub. 2, are of use as antiinflammatory agents and there is also disclosed a method for the treatment of immunoinflammatory conditions, such as allergy, anaphylaxis, asthma and inflammation in mammals, as well as in the modulation of PAF-mediated biological processes, such as embryonic implantation, thus making the compounds useful as antifertility agents.