Inventors:
Ludwig Bär - Erlangen, DE
Oliver Hayden - Herzogenaurach, DE
Michael Johannes Helou - Regensburg, DE
Mischa Megens - Millbrae CA, US
Mathias Reisbeck - Obertraubling, DE
Manfred Rührig - Lauf a.d. Pegnitz, DE
Sandro Francesco Tedde - Erlangen, DE
Assignee:
The Regents of the University of California - Berkeley CA
Siemens Aktiengesellschaft - Munich
International Classification:
C12Q 1/02
C12M 1/42
B82Y 15/00
US Classification:
435 29, 4352871, 977838, 977902
Abstract:
A magnetic flow cytometry apparatus for detection of cells labeled with magnetic nanoparticles has at least one pair of oppositely oriented magnets to provide between the magnets a first magnetic field region with a low magnetic field strength and to provide at poles of the magnets second magnetic field regions with a high magnetic field strength. The magnetic labeled cells provided within a flow input into the magnetic flow cytometry apparatus are enriched in at least one of the second magnetic field regions and supplied to the first magnetic field region, where a magnetic field is applied to the enriched magnetic labeled cells to measure the magnetic relaxation of the magnetic labeled cells in response to the applied magnetic field.