Michael P Derieg

40175316, Apr 12, 1977

Apr 12, 1976

5/676077

Michael Edward Derieg - Caldwell NJ
James Valentine Earley - Cedar Grove NJ
Rodney Ian Fryer - North Caldwell NJ
Leo Henryk Sternbach - Upper Montclair NJ

Hoffmann-La Roche Inc. - Nutley NJ

C07C 6996

260463

Tricyclic benzodiazepine derivatives ("A") bearing a hydroxylower alkyl substituent in the 1-position and a heterocyclic ring joined between positions 4 and 5 of the benzodiazepine moiety are described. The heterocyclic ring will contain the nitrogen atom appearing at position 4 of the benzodiazepine ring as well as the hetero atom, which may be either oxygen or nitrogen, attached to the carbon atom at the 5-position of the benzodiazepine ring. A bearing an oxygen atom in the new heterocyclic ring may be formed from the corresponding 4,5-unsaturated benzodiazepines by treatment with an epoxide compound in the presence of an acid catalyst. A bearing either a nitrogen or an oxygen atom in the new heterocyclic ring may be prepared by cyclization of the corresponding open compound. A are useful as sedative, muscle relaxant and anti-convulsant agents.

39651517, Jun 22, 1976

Mar 11, 1975

5/557438

Michael Edward Derieg - Caldwell NJ
James Valentine Earley - Cedar Grove NJ
Rodney Ian Fryer - North Caldwell NJ
Leo Henryk Sternbach - Upper Montclair NJ

Hoffmann-La Roche Inc. - Nutley NJ

C07C 9710
C07C10342

260490

Tricyclic benzodiazepine derivatives ("A") bearing a hydroxylower alkyl substituent in the 1-position and a heterocyclic ring joined between positions 4 and 5 of the benzodiazepine moiety are described. The heterocyclic ring will contain the nitrogen atom appearing at position 4 of the benzodiazepine ring as well as the hetero atom, which may be either oxygen or nitrogen, attached to the carbon atom at the 5-position of the benzodiazepine ring. "A" bearing an oxygen atom in the new heterocyclic ring may be formed from the corresponding 4,5-unsaturated benzodiazepines by treatment with an epoxide compound in the presence of an acid catalyst. "A" bearing either a nitrogen or an oxygen atom in the new heterocyclic ring may be prepared by cyclization of the corresponding open compound. "A" are useful as sedative, muscle relaxant and anti-convulsant agents.

40496660, Sep 20, 1977

Apr 12, 1976

5/676020

Michael Edward Derieg - Caldwell NJ
James Valentine Earley - Cedar Grove NJ
Rodney Ian Fryer - North Caldwell NJ
Leo Henryk Sternbach - Upper Montclair NJ

Hoffman-La Roche Inc. - Nutley NJ

C07D21324

2602948R

Tricyclic benzodiazepine derivatives (A) bearing a hydroxylower alkyl substituent in the 1-position and a heterocyclic ring joined between positions 4 and 5 of the benzodiazepine moiety are described. The heterocyclic ring will contain the nitrogen atom appearing at position 4 of the benzodiazepine ring as well as the hetero atom, which may be either oxygen or nitrogen, attached to the carbon atom at the 5-position of the benzodiazepine ring. A bearing an oxygen atom in the new heterocyclic ring may be formed from the corresponding 4,5-unsaturated benzodiazepines by treatment with an epoxide compound in the presence of an acid catalyst. A bearing either a nitrogen or an oxygen atom in the new heterocyclic ring may be prepared by cyclization of the corresponding open compound. A are useful as sedative, muscle relaxant and anti-convulsant agents.

40496678, Sep 20, 1977

Apr 12, 1976

5/675842

Michael Edward Derieg - Caldwell NJ
James Valentine Earley - Cedar Grove NJ
Rodney Ian Fryer - North Caldwell NJ
Leo Henryk Sternbach - Upper Montclair NJ

Hoffmann-La Roche Inc. - Nutley NJ

C07D21324

2602948R

Tricyclic benzodiazepine derivatives ("A") bearing a hydroxylower alkyl substituent in the 1-position and a heterocyclic ring joined between positions 4 and 5 of the benzodiazepine moiety are described. The heterocyclic ring will contain the nitrogen atom appearing at position 4 of the benzodiazepine ring as well as the hetero atom, which may be either oxygen or nitrogen, attached to the carbon atom at the 5-position of the benzodiazepine ring. "A" bearing an oxygen atom in the new heterocyclic ring may be formed from the corresponding 4,5-unsaturated benzodiazepines by treatment with an epoxide compound in the presence of an acid catalyst. "A" bearing either a nitrogen or an oxygen atom in the new heterocyclic ring may be prepared by cyclization of the corresponding open compound. "A" are useful as sedative, muscle relaxant and anti-convulsant agents.

40175324, Apr 12, 1977

Apr 12, 1976

5/676092

Michael Edward Derieg - Caldwell NJ
James Valentine Earley - Cedar Grove NJ
Rodney Ian Fryer - North Caldwell NJ
Leo Henryk Sternbach - Upper Montclair NJ

Hoffmann-La Roche Inc. - Nutley NJ

C07C 6996

260463

Tricyclic benzodiazepine derivatives ("A") bearing a hydroxylower alkyl substituent in the 1-position and a heterocyclic ring joined between positions 4 and 5 of the benzodiazepine moiety are described. The heterocyclic ring will contain the nitrogen atom appearing at position 4 of the benzodiazepine ring as well as the hetero atom, which may be either oxygen or nitrogen, attached to the carbon atom at the 5-position of the benzodiazepine ring. "A" bearing an oxygen atom in the new heterocyclic ring may be formed from the corresponding 4,5-unsaturated benzodiazepines by treatment with an epoxide compound in the presence of an acid catalyst. "A" bearing either a nitrogen or an oxygen atom in the new heterocyclic ring may be prepared by cyclization of the corresponding open compound. "A" are useful as sedative, muscle relaxant and anti-convulsant agents.

40149161, Mar 29, 1977

Apr 12, 1976

5/676091

Michael Edward Derieg - Caldwell NJ
James Valentine Earley - Cedar Grove NJ
Rodney Ian Fryer - North Caldwell NJ
Leo Henryk Sternbach - Upper Montclair NJ

Hoffmann-La Roche Inc. - Nutley NJ

C07C 6996

260463

Tricyclic benzodiazepine derivatives ("A") bearing a hydroxylower alkyl substituent in the 1-position and a heterocyclic ring joined between positions 4 and 5 of the benzodiazepine moiety are described. The heterocyclic ring will contain the nitrogen atom appearing at position 4 of the benzodiazepine ring as well as the hetero atom, which may be either oxygen or nitrogen, attached to the carbon atom at the 5-position of the benzodiazepine ring. "A" bearing an oxygen atom in the new heterocyclic ring may be formed from the corresponding 4,5-unsaturated benzodiazepines by treatment with an epoxide compound in the presence of an acid catalyst. "A" bearing either a nitrogen or an oxygen atom in the new heterocyclic ring may be prepared by cyclization of the corresponding open compound. "A" are useful as sedative, muscle relaxant and anti-convulsant agents.

39975916, Dec 14, 1976

Apr 12, 1976

5/675658

Michael Edward Derieg - Caldwell NJ
James Valentine Earley - Cedar Grove NJ
Rodney Ian Fryer - North Cadwell NJ
Leo Henryk Sternbach - Upper Montclair NJ

Hoffmann-La Roche Inc. - Nutley NJ

C07C14960

260470

Tricyclic benzodiazepine derivatives (A) bearing a hydroxylower alkyl substituent in the 1-position and a heterocyclic ring joined between positions 4 and 5 of the benzodiazepine moiety are described. The heterocyclic ring will contain the nitrogen atom appearing at position 4 of the benzodiazepine ring as well as the hetero atom, which may be either oxygen or nitrogen, attached to the carbon atom at the 5-position of the benzodiazepine ring. "A" bearing an oxygen atom in the new heterocyclic ring may be formed from the corresponding 4,5-unsaturated benzodiazepines by treatment with an epoxide compound in the presence of an acid catalyst. "A" bearing either a nitrogen or an oxygen atom in the new heterocyclic ring may be prepared by cyclization of the corresponding open compound. "A" are useful as sedative, muscle relaxant and anti-convulsant agents.