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Mehdi M Numa

from San Diego, CA
Age ~53
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Also known as:
Mehdi D Numa, Medhi Numa
Phone and address:
3403 42Nd St, San Diego, CA 92105
Related to:
Heather Numa Numa, 32Olivia M Numa, 29
Connected to:
Amy L Numa, 43David J Numa, 27Hebed Numa, 50Michaelle Numa, 80Ingibjorg Numadottir, 64Mark L Numainville, 50Nabih N Numair, 46Susan B Numair, 69Ali Numan, 48Karriem A Numan, 48

Mehdi Numa Phones & Addresses

  • 3403 42Nd St, San Diego, CA 92105

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Mehdi Numa Photo 1

Mehdi Numa

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Location:
Greater San Diego Area
Industry:
Pharmaceuticals
Mehdi Numa Photo 2

Mehdi Numa

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Publications

Us Patents

Heterocyclic Derivatives As Modulators Of Ion Channels

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US Patent:
8343763, Jan 1, 2013
Filed:
Feb 22, 2012
Appl. No.:
13/402519
Inventors:
Nicole Hilgraf - San Diego CA, US
Peter Diederik Jan Grootenhuis - San Diego CA, US
Mehdi Numa - San Diego CA, US
Dean Stamos - Carlsbad CA, US
Corey Anderson - San Diego CA, US
Tara Whitney - San Diego CA, US
Assignee:
Vertex Pharmaceuticals Incorporated - Cambridge MA
International Classification:
A61K 31/427
A61P 29/00
A61P 19/02
A61P 25/06
A61P 25/00
A61P 25/08
A61P 25/28
A61P 25/24
A61P 25/22
A61P 9/06
A61P 25/18
A61P 21/00
A61P 1/00
A61P 13/10
A61P 9/12
US Classification:
435375, 514370
Abstract:
The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

Process For Preparing Modulators Of Cystic Fibrosis Transmembrane Conductance Regulator

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US Patent:
8344147, Jan 1, 2013
Filed:
Oct 21, 2010
Appl. No.:
12/909750
Inventors:
Narendra Bhalchandra Ambhaikar - Hyderabad, IN
Robert Hughes - San Diego CA, US
Dennis James Hurley - San Marcos CA, US
Elaine Chungmin Lee - Cambridge MA, US
Benjamin Littler - Carlsbad CA, US
Mehdi Numa - San Diego CA, US
Stefanie Roeper - Cambridge MA, US
Urvi Sheth - San Diego CA, US
Assignee:
Vertex Pharmaceutical Incorporated - Cambridge MA
International Classification:
C07D 487/08
C07D 215/56
US Classification:
546156, 548453
Abstract:
The present invention relates to processes for preparing solid state forms of N-(4-(7-azabicyclo[2. 2. 1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1, 4-dihydroquinoline-3-carboxamide, including Compound 1 Form A, Compound 1 Form A-HCl, Compound 1 Form B, and Compound 1 Form B-HCl, any combination of these forms, pharmaceutical compositions thereof, and methods of treatment therewith.

Modulators Of Atp-Binding Cassette Transporters

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US Patent:
8575209, Nov 5, 2013
Filed:
Nov 17, 2010
Appl. No.:
12/948162
Inventors:
Sara S. Hadida Ruah - La Jolla CA, US
Peter D. J. Grootenhuis - San Diego CA, US
Fredrick F. Van Goor - San Diego CA, US
Jinglan Zhou - San Diego CA, US
Brian Bear - Oceanside CA, US
Mark T. Miller - San Diego CA, US
Jason McCartney - Cardiff by the Sea CA, US
Mehdi Numa - San Diego CA, US
Xiaoqing Yang - San Diego CA, US
Assignee:
Vertex Pharmaceuticals Incorporated - Cambridge MA
International Classification:
A61K 31/36
C07D 405/12
US Classification:
514414, 548526
Abstract:
Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

Heterocyclic Chromene-Spirocyclic Piperidine Amides As Modulators Of Ion Channels

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US Patent:
8598164, Dec 3, 2013
Filed:
May 6, 2011
Appl. No.:
13/102335
Inventors:
Edward Adam Kallel - Escondido CA, US
Mark Thomas Miller - San Diego CA, US
Joseph Pontillo - San Diego CA, US
Vijayalaksmi Arumugam - San Marcos CA, US
Nicole Hilgraf - San Diego CA, US
Jason McCartney - Cardiff by the Sea CA, US
Peter Diederik Jan Grootenhuis - San Diego CA, US
Corey Anderson - San Diego CA, US
Mehdi Numa - San Diego CA, US
Bryan A. Frieman - San Diego CA, US
Brian Richard Bear - Oceanside CA, US
Assignee:
Vertex Pharmaceuticals Incorporated - Cambridge MA
International Classification:
C07D 491/22
C07D 498/22
A61K 31/5386
A61K 31/438
US Classification:
5142295, 544 71, 546 17, 514278
Abstract:
The invention relates to heterocyclic chromene-spirocyclic piperidine amides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

Modulators Of Atp-Binding Cassette Transporters

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US Patent:
20070244159, Oct 18, 2007
Filed:
Apr 9, 2007
Appl. No.:
11/786001
Inventors:
Sara Hadida Ruah - La Jolla CA, US
Peter Grootenhuis - San Diego CA, US
Frederick Van Goor - San Diego CA, US
Jinglan Zhou - San Diego CA, US
Brian Bear - Oceanside CA, US
Mark Miller - San Diego CA, US
Jason McCartney - Cardiff by the Sea CA, US
Mehdi Numa - San Diego CA, US
International Classification:
A61K 31/454
A61K 31/42
A61K 31/4178
A61K 31/405
C07D 413/02
C07D 403/02
US Classification:
514323000, 514378000, 514397000, 514414000, 514419000, 514381000, 546201000, 548253000, 548311100, 548465000, 548495000, 548243000
Abstract:
Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

Heterocyclic Derivatives As Modulators Of Ion Channels

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US Patent:
20110098328, Apr 28, 2011
Filed:
Oct 28, 2010
Appl. No.:
12/913869
Inventors:
Nicole Hilgraf - San Diego CA, US
Peter Diederik Jan Grootenhuis - San Diego CA, US
Mehdi Numa - San Diego CA, US
Dean Stamos - Carlsbad CA, US
Corey Anderson - San Diego CA, US
Tara Whitney - San Diego CA, US
Assignee:
VERTEX PHARMACEUTICALS INCORPORATED - Cambridge MA
International Classification:
A61K 31/427
C12N 1/00
A61P 29/00
A61P 25/00
A61P 25/06
A61P 19/02
A61P 25/08
A61P 25/24
A61P 25/22
A61P 1/00
A61P 3/10
A61P 31/18
A61P 21/00
A61P 13/00
A61P 13/02
US Classification:
514370, 4353171
Abstract:
The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

Modulators Of Atp-Binding Cassette Transporters

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US Patent:
20120309758, Dec 6, 2012
Filed:
Jun 8, 2012
Appl. No.:
13/492164
Inventors:
Urvi Sheth - San Diego CA, US
Lev T.D. Fanning - San Marcos CA, US
Mehdi Numa - San Diego CA, US
Hayley Binch - Encinitas CA, US
Dennis James Hurley - San Marcos CA, US
Jinglan Zhou - San Diego CA, US
Sara S. Hadida Ruah - La Jolla CA, US
Anna R. Hazlewood - San Diego CA, US
Alina Silina - San Diego CA, US
Rajendran Vairagoundar - Kalamazoo MI, US
Fredrick F. Van Goor - San Diego CA, US
Peter Diederik Jan Grootenhuis - San Diego CA, US
Martyn C. Botfield - Concord MA, US
Assignee:
Vertex Pharmaceuticals Incorporated - Cambridge MA
International Classification:
A61K 31/47
A61K 31/4709
C12N 5/071
C07D 215/56
C07D 413/12
A61K 31/5377
A61P 29/00
A61P 25/08
A61P 25/16
A61P 25/28
A61P 25/00
A61P 3/00
A61P 11/00
A61P 1/18
A61P 19/10
A61P 3/10
A61P 27/02
A61P 11/06
A61P 15/08
C07D 401/12
US Classification:
5142352, 546156, 514312, 435375, 544128
Abstract:
The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

Process For Preparing Modulators Of Cystic Fibrosis Transmembrane Conductance Regulator

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US Patent:
20130072687, Mar 21, 2013
Filed:
Nov 16, 2012
Appl. No.:
13/678840
Inventors:
Vertex Pharmaceuticals Incorporated - Cambridge MA, US
Robert Hughes - San Diego CA, US
Dennis James Hurley - San Marcos CA, US
Elaine Chungmin Lee - Cambridge MA, US
Benjamin Littler - Carlsbad CA, US
Mehdi Numa - San Diego CA, US
Stefanie Roeper - Medford MA, US
Urvi Sheth - San Diego CA, US
Assignee:
Vertex Pharmaceuticals Incorporated - Cambridge MA
International Classification:
C07D 487/08
US Classification:
546156
Abstract:
The present invention relates to processes for preparing solid state forms of N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide, including Compound 1 Form A, Compound 1 Form A-HCl, Compound 1 Form B, and Compound 1 Form B-HCl, any combination of these forms, pharmaceutical compositions thereof, and methods of treatment therewith.
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Mehdi M Numa from San Diego, CA, age ~53 Get Report