US Patent:
20090324612, Dec 31, 2009
Inventors:
Daniel L. KAUFMAN - Los Angeles CA, US
Lorraine WASHBURN - San Dimas CA, US
Dan ZEKZER - Encinitas CA, US
International Classification:
A61K 39/395
G01N 33/567
A61K 38/16
A61K 31/7088
US Classification:
4241581, 435 721, 514 12, 514 44 R
Abstract:
Compositions and methods for modulating neural outgrowth, including treating neural damage, via the major histocompatibility complex I (“MHC I”) molecule. Methods for identifying agents that reduce MHC I-induced inhibition of neurite outgrowth. Methods for promoting neural outgrowth comprising administering MHC I molecules (native, recombinant, or those encoded by gene fusion) or biologically-active fragments thereof. Pharmaceutical compositions comprising vectors comprising nucleic acid sequences encoding MHC I in operable linkage with a promoter and a pharmaceutically-acceptable carrier or diluent. Small interfering RNA (“siRNA”) that down-regulates expression of an MHC I gene.