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Lihren R Chen

from Wayland, MA
Age ~60

Lihren Chen Phones & Addresses

  • 82 Hawthorne Rd, Wayland, MA 01778
  • 129 Page Rd, Bedford, MA 01730
  • 1643 Cambridge St, Cambridge, MA 02138
  • San Diego, CA
  • 426 Trapelo Rd, Belmont, MA 02478
  • 21 Madison Ave #2, Cambridge, MA 02140

Publications

Us Patents

Inhibitors Of Phospholipase Enzymes

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US Patent:
6500853, Dec 31, 2002
Filed:
Oct 11, 2000
Appl. No.:
09/686616
Inventors:
Jasbir S. Seehra - Lexington MA
John C. McKew - Arlington MA
Frank Lovering - Acton MA
Jean E. Bemis - Arlington MA
YiBin Xiang - Acton MA
Lihren Chen - Cambridge MA
John L. Knopf - Acton MA
Assignee:
Genetics Institute, LLC - Cambridge MA
International Classification:
A61K 31405
US Classification:
514415, 548509, 548250, 514339, 514381, 5462774
Abstract:
This invention concerns compounds and pharmaceutical compositions useful for treating or preventing inflammatory conditions in a mammal, the methods comprising administration of novel pharmaceutically useful compounds of the general formulae: or pharmaceutically acceptable salts thereof, wherein R -R are as defined in the specification.

Methods For The Use Of Inhibitors Of Cytosolic Phospholipase A2

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US Patent:
7605156, Oct 20, 2009
Filed:
May 27, 2005
Appl. No.:
11/140390
Inventors:
John C. McKew - Arlington MA,
Steve Y. Tam - Wellesley MA,
Katherine L. Lee - West Newton MA,
Lihren Chen - Cambridge MA,
Paresh Thakker - Boston MA,
Fuk-Wah Sum - Pomona NY,
Mark L. Behnke - Somerville MA,
Baihua Hu - Audubon PA,
James D. Clark - Acton MA,
Wei Li - Acton MA,
Valerie Clerin - Watertown MA,
Suzana Marusic - Reading MA,
Kevin Pong - Robbinsville NJ,
Assignee:
Wyeth - Madison NJ
International Classification:
A61K 31/54
US Classification:
5142282, 514374, 514375, 514381, 514386, 514406, 514414, 5142335, 51425409, 514256, 514365, 514339, 514345, 544 582, 544143, 544333, 544373, 546 16, 546201, 5462774, 546115
Abstract:
This invention provides methods for the use of substituted indole compounds of the general formula:.

Omega-Deoxy-Azasugars

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US Patent:
5596005, Jan 21, 1997
Filed:
Dec 23, 1993
Appl. No.:
8/172880
Inventors:
Tetsuya Kajimoto - Kumamoto,
Lihren Chen - San Diego CA
Assignee:
The Scripps Research Institute - LaJolla CA
International Classification:
A61K 3144
C07D21140
US Classification:
514335
Abstract:
Omega-deoxy-azapyranose compounds, processes of making and using the same are disclosed, as are a process of making omega-deoxy-azafuranose compounds.

11-Beta Hsd1 Inhibitors

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US Patent:
2010002, Feb 4, 2010
Filed:
Aug 11, 2009
Appl. No.:
12/539232
Inventors:
Jason Shaoyun Xiang - Winchester MA,
Eddine Saiah - Brookline MA,
Steve Y. Tam - Wellesley MA,
John C. McKew - Arlington MA,
Lihren Chen - Bedford MA,
Manus Ipek - Watertown MA,
Katherine Lee - West Newton MA,
Jianchang Li - Carlisle MA,
Wei Li - Acton MA,
Tarek Suhayl Mansour - New City NY,
Vipin Suri - Waltham MA,
Richard Vargas - Lexington MA,
Yuchuan Wu - Acton MA,
Jinbo Lee - Andover MA,
Eva Binnun - Boston MA,
Douglas P. Wilson - Ayer MA,
International Classification:
A61K 31/5377
A61K 31/497
A61K 31/4965
A61K 31/4545
US Classification:
5142358, 51425301, 51425502, 514318
Abstract:
This invention relates to inhibiting 11βHSD1.

Inhibitors Of Cytosolic Phospholipase A2

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US Patent:
2010002, Feb 4, 2010
Filed:
Jun 19, 2009
Appl. No.:
12/488020
Inventors:
John C. McKew - Arlington MA,
Katherine L. Lee - Newton MA,
Lihren Chen - Bedford MA,
Richard Vargas - Brighton MA,
James D. Clark - Acton MA,
Cara Williams - Methuen MA,
Valerie Clerin - Watertown MA,
Suzana Marusic - Reading MA,
Kevin Pong - Robbinsville NJ,
International Classification:
A61K 31/5377
C07D 209/04
C07D 403/02
C07D 413/02
A61K 31/405
A61K 31/497
A61P 29/00
A61P 19/02
A61P 25/00
A61P 7/02
US Classification:
5142352, 548491, 544373, 544143, 514415, 51425409
Abstract:
This invention provides chemical inhibitors of the activity of various phospholipase enzymes, particularly cytosolic phospholipase Aenzymes (cPLA), more particularly including inhibitors of cytosolic phospholipase Aalpha enzymes (cPLAα). In some embodiments, the inhibitors have the Formula I:wherein the constituent variables are as defined herein.

Inhibitors Of Cytosolic Phospholipase A

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US Patent:
8283373, Oct 9, 2012
Filed:
Jun 19, 2009
Appl. No.:
12/488182
Inventors:
John C. McKew - Arlington MA,
Katherine L. Lee - Newton MA,
Lihren Chen - Bedford MA,
Richard Vargas - Brighton MA,
James D. Clark - Acton MA,
Cara Williams - Methuen MA,
Valerie Clerin - Watertown MA,
Suzana Marusic - Reading MA,
Kevin Pong - Robbinsville NJ,
Assignee:
Pfizer Inc. - New York NY
International Classification:
A61K 31/404
US Classification:
514415
Abstract:
This invention provides chemical inhibitors of the activity of various phospholipase enzymes, particularly cytosolic phospholipase Aenzymes (cPLA), more particularly including inhibitors of cytosolic phospholipase Aalpha enzymes (cPLAα). In some embodiments, the inhibitors have the Formula I:.

Methods For The Use Of Inhibitors Of Cytosolic Phospholipase A2

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US Patent:
7906548, Mar 15, 2011
Filed:
Aug 11, 2009
Appl. No.:
12/539074
Inventors:
John C. McKew - Arlington MA,
Steve Y. Tam - Wellesley MA,
Katherine L. Lee - West Newton MA,
Lihren Chen - Cambridge MA,
Paresh Thakker - Boston MA,
Fuk-Wah Sum - Pomona NY,
Mark L. Behnke - Somerville MA,
Baihua Hu - Audubon PA,
James D. Clark - Acton MA,
Wei Li - Acton MA,
Valerie Clerin - Watertown MA,
Suzana Marusic - Reading MA,
Kevin Pong - Robbinsville NJ,
Assignee:
Wyeth LLC - Madison NJ
International Classification:
A01N 43/38
US Classification:
514415
Abstract:
This invention provides methods for the use of substituted indole compounds of the general formula:.

Methods For Treating Asthmatic Conditions

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US Patent:
7713964, May 11, 2010
Filed:
Nov 22, 2002
Appl. No.:
10/302171
Inventors:
John C. McKew - Arlington MA,
Steven Y. Tam - Wellesley MA,
Katherine L. Lee - West Newton MA,
Lihren Chen - Cambridge MA,
Paresh Thakker - Boston MA,
Fuk-Wah Sum - Pomona NY,
Mark Behnke - Sommerville MA,
Baihua Hu - Audubon PA,
James D. Clark - Acton MA,
Assignee:
Wyeth LLC - Madison NJ
International Classification:
A61K 31/54
A61K 31/535
A61K 31/497
A61K 31/44
A61K 31/425
A61K 31/41
A61K 31/415
A61K 31/40
US Classification:
5142282, 514374, 514375, 514381, 514406, 514414, 5142335, 51425409, 514365, 514278, 514339, 514826
Abstract:
This invention provides methods for treating in mammals asthma and asthmatic conditions using substituted indole compounds of the general formula:.
Lihren R Chen from Wayland, MA, age ~60 Get Report