Kyungjin Kim

6916833, Jul 12, 2005

Mar 4, 2004

10/793296

Kyungjin Kim - Livingston NJ, US
Emily Aijun Liu - Nutley NJ, US
Steven Gregory Mischke - Florham Park NJ, US

Hoffmann-La Roche Inc. - Nutley NJ

A61K031/445
C07D211/40
C07D211/50
C07D211/42

514328, 546217

The present invention provides compounds having formula (I): and formula (II): wherein X, n, and R-Rare defined herein, or a pharmaceutically acceptable salt thereof. The invention also provides a pharmaceutical composition comprising a therapeutically effective amount of a compound represented by formula (I) or (II) and a pharmaceutically acceptable carrier or excipient. The invention further provides a method for treating cancer comprising administering to a patient in need of such treatment a therapeutically effective amount of a compound represented by formula (I) or (II).

7060713, Jun 13, 2006

Mar 18, 2005

11/083750

Kyungjin Kim - Livingston NJ, US
Emily Aijun Liu - Nutley NJ, US
Steven Gregory Mischke - Florham Park NJ, US

Hoffmann-La Roche Inc. - Nutley NJ

A61K 31/445
C07D 211/40
C07D 211/44

514328, 546216, 546217

The present invention provides compounds having formula (II):.

7803816, Sep 28, 2010

Sep 25, 2006

11/526523

Steven Joseph Berthel - Mendham Township NJ, US
Shawn David Erickson - Leonia NJ, US
Nader Fotouhi - Basking Ridge NJ, US
Robert Francis Kester - West Orange NJ, US
Kyungjin Kim - Livingston NJ, US
Steven Gregory Mischke - Florham Park NJ, US
Yimin Qian - Wayne NJ, US
Kshitij Chhabilbhai Thakkar - Clifton NJ, US
Jefferson Wright Tilley - North Caldwell NJ, US
Hong Wang - Nutley NJ, US

Hoffmann-La Roche Inc. - Nutley NJ

A61K 31/454
C07D 403/02

514322, 546199

Provided herein are compounds of the formula (I):.

8188098, May 29, 2012

May 1, 2009

12/433921

Shawn David Erickson - Leonia NJ, US
Paul Gillespie - Westfield NJ, US
Kevin Richard Guertin - Verona NJ, US
Prabha Saba Karnachi - Hillsborough NJ, US
Kyungjin Kim - Livingston NJ, US
Chun Ma - Edgewater NJ, US
Warren William McComas - Denville NJ, US
Lida Qi - Leonia NJ, US
Jefferson Wright Tilley - North Caldwell NJ, US
Qiang Zhang - Parsippany NJ, US

Hoffmann-La Roche Inc. - Nutley NJ

A01N 43/90
A61K 31/519
C07D 487/00

5142621, 544262

Provided herein are compounds of the formula (I):.

8420647, Apr 16, 2013

Jan 13, 2011

13/005566

Caterina Bissantz - Village-Neuf, FR
Henrietta Dehmlow - Loerrach, DE
Shawn David Erickson - Leonia NJ, US
Kyungjin Kim - Livingston NJ, US
Rainer E. Martin - Basel, CH
Ulrike Obst Sander - Reinach BL, CH
Hans Richter - Grenzach-Wyhlen, DE
Christoph Ulmer - Fischingen, DE

Hoffmann-La Roche Inc. - Nutley NJ

A61K 31/498

514249, 544353

This invention relates to novel phenyl amide or pyridyl amide derivatives of the formula.

7262297, Aug 28, 2007

Apr 30, 2004

10/836507

Steven Joseph Berthel - Mendham Township NJ, US
Adrian Wai-Hing Cheung - Glen Rock NJ, US
Kyungjin Kim - Livingston NJ, US
Kshitij Chhabilbhai Thakkar - Nutley NJ, US
Weiya Yun - Warren NJ, US

Hoffmann-La Roche Inc. - Nutley NJ

C07D 239/00
C07D 487/00

544249, 544250

The invention relates to pyrimido[5,4-e][1,2,4]triazine-5,7-diamine compounds which are useful for inhibiting protein tyrosine phosphatases, particularly PTP1B, and are useful for lowering blood glucose concentrations in mammals.

20020151554, Oct 17, 2002

Jan 9, 2002

10/042619

Li Chen - Westfield NJ, US
Qingjie Ding - Bridgewater NJ, US
Paul Gillespie - Westfield NJ, US
Kyungjin Kim - Livingston NJ, US
Allen Lovey - North Caldwell NJ, US
Warren McComas - Denville NJ, US
John Mullin - Hawthorne NJ, US
Agostino Perrotta - Bloomfield NJ, US

A61K031/496
C07D417/02

514/254020, 544/369000

Disclosed are novel diaminothiazoles that are selective inhibitors of Cdk4. These compounds and their pharmaceutically acceptable salts and esters are anti-proliferative agents useful in the treatment or control of solid tumors, in particular breast, colon, lung and prostate tumors. Also disclosed are pharmaceutical compositions containing these compounds as well as intermediates useful in the preparation of the compounds.

20070021445, Jan 25, 2007

Jul 18, 2006

11/488863

Steven Berthel - Mendham Township NJ, US
Adrian Cheung - Glen Rock NJ, US
Kyungjin Kim - Livingston NJ, US
Shiming Li - Edison NJ, US
Kshitij Thakkar - Clifton NJ, US
Weiya Yun - Warren NJ, US

A61K 31/519
C07D 487/04

514264110, 544279000

The present invention comprises pyridopyrimidinediamine compounds of the general formula I: The compounds of the present invention are potent inhibitors of PTP1B. Accordingly, the invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and diabetes-related diseases.