Kenneth R Wada

6472144, Oct 29, 2002

Mar 20, 2001

09/813922

Patricia J. Malin - Palo Alto CA
Kenneth R. Wada - San Jose CA
Peter J. Dehlinger - Palo Alto CA

Cellstat Technologies, Inc. - Belmont CA

C12Q 100

435 4, 4352871, 4352884, 422 8201, 422 8202, 204400, 204403

High-throughput screening method and apparatus are described. The method includes placing cells on a substrate defining a plurality of discrete microwells, at a well density of greater than about 100/cm , with the number of cells in each well being less than about 1000, and where the cells in each well have been exposed to a selected agent. The change in conductance in each well is determined by applying a low-voltage, AC signal across a pair of electrodes paced in that well, and synchronously measuring the conductance across the electrodes, to monitor the level of growth or metabolic activity of cells contained in each well. Also disclosed is an apparatus for carrying out the screening method.

7354704, Apr 8, 2008

Oct 29, 2002

10/284053

Patricia J. Malin - Palo Alto CA, US
Kenneth R. Wada - San Jose CA, US
Peter J. Dehlinger - Palo Alto CA, US

CellStat Technologies, Inc. - Palo Alto CA

C12Q 1/00
C40B 30/06
C40B 30/10

435 4, 506 10, 506 12

High-throughput screening method and apparatus arm described. The method includes placing cells on a substrate defining a plurality of discrete microwells, at a well density of greater than about 100/cm, with the number of cells in each well being less than about 1000, and where the cells in each well have been exposed to a selected agent. The change in conductance in each well is determined by applying a low-voltage, AC signal across a pair of electrodes placed in that well, and synchronously measuring the conductance across the electrodes, to monitor the level of growth or metabolic activity of cells contained in each well. Also disclosed is an apparatus for carrying out the screening method.

62355201, May 22, 2001

May 14, 1999

9/202658

Patricia J. Malin - Palo Alto CA
Kenneth R. Wada - San Jose CA
Peter J. Dehlinger - Palo Alto CA

Cellstat Technologies, Inc. - Belmont CA

C12M 134

4352871

High-throughout screening method and apparatus are described. The method includes placing cells on a substrate defining a plurality of discrete microwells, at a well density of greater than about 100/cm. sup. 2, with the number of sells in each well being less that about 1000, and where the cells in each well have been exposed to a selected agent. The change in conductance in each well is determined by applying a low-voltage, AC signal across a pair of electrodes placed in that well, and synchronously measuring the conductance across the electrodes, to monitor the level of growth or metabolic activity of cells contained in each well. Also disclosed is an apparatus for carrying out the screening method.

56437420, Jul 1, 1997

Mar 23, 1995

8/374542

Patricia J. Malin - Palo Alto CA
Kenneth Richard Wada - Cupertino CA
Oskar Werner Huber - Belmont CA

CellStat Technologies, Inc. - Belmont CA

C12Q 100
C12M 134
C12M 142

435 29

This invention provides an improved system for monitoring and recording cell cultures. A method for measuring a delay period for an alternating current voltage applied across a pair of pins improves the stability of measurements made with the improved system. A method for applying a voltage across a pair of pins which avoids exceeding a pre-established voltage avoids the possibility of damaging and/or destroying cells while monitoring their culture.

50080814, Apr 16, 1991

Oct 11, 1988

7/256022

David A. Blau - Cupertino CA
John Meadows - Los Altos Hills CA
Thomas M. Sherlock - Los Altos Hills CA
Fred Stengel - Redwood City CA
Robert M. Studholme - Saratoga CA
Kenneth R. Wada - San Jose CA
Christopher J. Kepner - San Jose CA

KD Group - Mountain View CA

G01N 3500

422 64

Computer-controlled method and apparatus for automatic melt index testing, including a housing with a base carrying a heater block having a bore therein for receiving a metal cartridge. A cartridge carousel is rotatably carried on the base, and carries a plurality of such cartridges, each cartridge having a plug at the bottom end thereof with a orifice through the plug, and each cartridge having a bore therein for receiving a sample of a test substance and for receiving a piston on top of the pellets. A lift arm grasps the cartridges, one at a time, and places each cartridge into the heater block, under the control of a microcomputer, by both lifting and rotating the transfer arm. The transfer arm includes a solenoid-operated grip for grasping the cartridges. The test unit carries a lift mechanism with a weight mounted atop a tamping rod, and an optical sensor for determining the height of the weight relative to the lift machinism. The weight is lowered by the lifting mechanism until it bears down upon the pellets, and then the cartridge is heated until the test substance melts.