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Kenneth Stauderman Phones & Addresses

  • 3615 Lotus St, San Diego, CA 92106
  • La Jolla, CA
  • San Antonio, TX
  • Cincinnati, OH
  • 3615 Lotus Dr, San Diego, CA 92106

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Kenneth Stauderman Photo 1

Vice-President, Research At Calcimedica

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Location:
Greater San Diego Area
Industry:
Biotechnology
Experience:
CalciMedica (Privately Held; Biotechnology industry): Vice-President, Research,  (April 2007-Present) TorreyPines Therapeutics (Biotechnology industry): Executive Director of Cell Biology & Lead Discovery,  (2000-2007) Merck Research Labs ...

Publications

Us Patents

Composition Comprising A Cell Comprising A Stim1 Protein And An Agent That Modulates Intracellular Calcium And Methods Of Use

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US Patent:
7645588, Jan 12, 2010
Filed:
Mar 3, 2004
Appl. No.:
10/547720
Inventors:
Jack Roos - San Diego CA,
Kenneth A. Stauderman - San Diego CA,
Gonul Velicelebi - San Diego CA,
Paul J. Digregorio - San Diego CA,
Kari Lynn Ohlsen - San Diego CA,
Assignee:
CalciMedica, Inc. - La Jolla CA
International Classification:
G01N 33/53
C12P 21/02
C07K 14/435
A61K 33/06
US Classification:
435 72, 435 691, 530350, 424682
Abstract:
Methods are provided for identifying agents that modulate intracellular calcium. Also provided are methods of modulating calcium within cells and methods of identifying proteins involved in modulating intracellular calcium.

Methods Of Modulating And Of Identifying Agents That Modulate Intracellular Calcium

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US Patent:
20040009537, Jan 15, 2004
Filed:
Jan 13, 2003
Appl. No.:
10/342844
Inventors:
Jack Roos - San Diego CA,
Kenneth Stauderman - San Diego CA,
Gonul Velicelebi - San Diego CA,
International Classification:
C12Q001/68
G01N033/53
G01N033/567
C12N005/06
US Classification:
435/007200, 435/348000, 435/006000
Abstract:
Methods are provided for identifying agents that modulate intracellular calcium. Also provided are methods of modulating calcium within cells and treating disease by modulating intracellular calcium. Also provided are methods of screening for nucleic acids encoding candidate ion transport proteins and methods of identifying nucleic acids encoding ion transport proteins.

Compounds That Modulate Intracellular Calcium

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US Patent:
20130245025, Sep 19, 2013
Filed:
Jan 3, 2013
Appl. No.:
13/733795
Inventors:
Gonul Velicelebi - San Diego CA,
Kenneth A. Stauderman - San Diego CA,
Jeffrey P. Whitten - Santee CA,
Yazhong Pei - San Diego CA,
Jianguo Cao - San Diego CA,
Zhijun Wang - San Diego CA,
Evan Rogers - San Diego CA,
Brian Dyck - San Diego CA,
Jonathan Grey - San Diego CA,
Assignee:
CalciMedica, Inc. - La Jolla CA
International Classification:
C07D 333/38
C07D 471/04
C07D 417/12
C07D 409/12
C07D 495/04
C07D 413/12
C07D 491/048
US Classification:
514249, 548217, 514375, 546121, 514300, 546115, 514302, 544355, 544350, 544237, 514248, 549 50, 514443, 549 69, 514447, 548178, 514367, 546146, 514307, 548126, 514361
Abstract:
Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

Compounds That Modulate Intracellular Calcium

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US Patent:
20130231344, Sep 5, 2013
Filed:
Jan 4, 2013
Appl. No.:
13/734087
Inventors:
Kenneth A. Stauderman - San Diego CA,
Jeffrey P. Whitten - Santee CA,
Yazhong Pei - San Diego CA,
Jianguo Cao - San Diego CA,
Zhijun Wang - San Diego CA,
Evan Rogers - San Diego CA,
Brian Dyck - San Diego CA,
Jonathan Grey - San Diego CA,
Assignee:
CalciMedica, Inc. - La Jolla CA
International Classification:
C07D 409/04
C07D 417/04
C07D 471/04
C07D 413/14
C07D 417/14
C07D 409/14
C07D 333/38
US Classification:
514249, 5483657, 514406, 549 60, 514444, 5462804, 514336, 548204, 514365, 549 59, 544405, 51425505, 5483047, 514394, 548159, 514367, 546167, 514314, 546213, 514326, 544333, 514256, 548467, 514414, 546139, 544238, 51425205, 51425202, 546121, 514300, 544353, 435375
Abstract:
Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

Compounds That Modulate Intracellular Calcium

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US Patent:
20130123265, May 16, 2013
Filed:
Jan 4, 2013
Appl. No.:
13/734827
Inventors:
Gonul Velicelebi - San Diego CA,
Kenneth A. Stauderman - San Diego CA,
Frank King - Herts,
Yazhong Pei - San Diego CA,
Jeffrey P. Whitten - Santee CA,
Assignee:
CalciMedica, Inc. - La Jolla CA
International Classification:
C07D 403/04
A61K 31/506
A61K 31/444
A61K 31/4436
A61K 31/4439
A61K 31/415
A61K 31/381
C07D 495/04
C07D 401/14
C07D 401/04
C07D 409/12
C07D 231/38
C07D 333/68
C07D 333/38
A61K 45/06
A61K 31/5025
US Classification:
514248, 435375, 514256, 514333, 514337, 514341, 514407, 514443, 514447, 544235, 544333, 546256, 5462754, 5462811, 5483725, 549 48, 549 69
Abstract:
Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases, disorders or conditions that would benefit from inhibition of SOC channel activity.

Compounds That Modulate Intracellular Calcium

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US Patent:
20130079348, Mar 28, 2013
Filed:
Mar 2, 2011
Appl. No.:
13/581984
Inventors:
Gonul Velicelebi - San Diego CA,
Kenneth A. Stauderman - San Diego CA,
Jeffrey P. Whitten - Santee CA,
Jianguo Cao - San Diego CA,
Zhijun Wang - San Diego CA,
Evan Rogers - San Diego CA,
Brian Dyck - San Diego CA,
Jonathan Grey - San Diego CA,
Assignee:
CalciMedica, Inc. - La Jolla CA
International Classification:
C07D 409/12
C07D 417/12
C07D 333/38
C07D 471/04
US Classification:
514249, 546121, 514300, 548180, 514367, 548465, 514414, 549 69, 514447, 5462814, 514336, 544235, 514248, 544355, 549 60
Abstract:
Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

Gamma-Secretase Modulatory Compounds, Methods For Identifying Same, And Uses Therefor

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US Patent:
20120289558, Nov 15, 2012
Filed:
Nov 8, 2010
Appl. No.:
13/508511
Inventors:
Maria Z. Kounnas - San Diego CA,
Elizabeth J. Ackermann - Del Mar CA,
Kenneth A. Stauderman - San Diego CA,
Gonul Velicelebi - San Diego CA,
Steve Wagner - San Diego CA,
International Classification:
C07D 417/10
A61K 31/427
G01N 27/62
G01N 33/573
US Classification:
514370, 435 71, 548193, 435 792, 435 23, 548198
Abstract:
In accordance with the present invention, it has been discovered that compounds which modulate the γ-secretase enzyme to make more of the shorter, less toxic and less aggregation-prone Aβ peptides (such as Aβ37 and Aβ38), while making less of the longer and more toxic and aggregation-prone AB peptides (such as AB40 and AB42) are useful as gamma-secretase modulators. In addition, these GSM compounds have further been discovered to have the selective property of modulating the formation of various AB peptides, while not inhibiting the overall activity of the γ-secretase enzyme. Thus, such compounds do not impede other critical functions of the γ-secretase enzyme, such as generating fragments from Notch that appear to control gene expression and cell differentiation. Therefore, in accordance with the present invention, there are provided screening assays useful for determining whether test compounds have GSM activity; accordingly, invention assays facilitate the identification of new gamma-secretase modulators. Such screening assays can be performed in a variety of ways, e.g., by assessing whether test compounds: lower the level of Aβ42 peptide, increase the level of Aβ37 and/or Aβ38 peptides, have substantially no effect on the processing of other γ-secretase substrates, and/or interact with at least one component of the γ-secretase complex. Also provided in accordance with the present invention are compounds having gamma-secretase modulatory activity as identified by any of the methods described herein; methods for producing formulations useful for modulating gamma-secretase activity, as well as the resulting formulations; methods for modulating gamma-secretase activity employing compounds identified according to invention methods and/or invention formulations, and the like.

Inhibitors Of Store Operated Calcium Release

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US Patent:
20120149673, Jun 14, 2012
Filed:
Feb 17, 2012
Appl. No.:
13/399017
Inventors:
Jeffrey P. Whitten - Santee CA,
Yazhong Pei - San Diego CA,
Kenneth A. Stauderman - San Diego CA,
Jack Roos - San Diego CA,
Assignee:
CalciMedica, Inc. - La Jolla CA
International Classification:
A61K 31/397
A61K 31/422
A61K 31/381
A61K 31/5375
A61K 31/4995
A61K 31/496
A61K 31/506
A61K 31/5377
A61K 31/538
A61P 13/12
A61P 27/02
A61P 1/16
A61P 11/00
A61P 1/00
A61P 17/00
A61P 19/02
A61P 21/00
A61P 11/02
A61P 15/02
A61P 19/10
A61P 37/06
A61P 3/10
A61P 7/06
A61P 11/06
A61P 17/06
A61P 25/00
A61P 29/00
C12N 5/071
US Classification:
51421002, 435375, 514378, 514445, 5142312, 514249, 51425213, 514275, 5142318, 5142305
Abstract:
Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases, disorders or conditions that would benefit from inhibition of SOC channel activity.
Kenneth Stauderman from San Diego, CA, age ~69 Get Report