US Patent:
20090311225, Dec 17, 2009
Inventors:
Kanaka Raju Koduri - White Plains NY, US
Assignee:
PSMA Development Company, LLC - Tarrytown NY
International Classification:
A61K 38/17
C07K 14/47
C12N 15/12
C12N 15/85
C12N 5/10
A61K 31/7088
A61K 35/12
A61K 48/00
C12P 21/00
A61P 35/00
C12P 21/02
US Classification:
424 9321, 530350, 514 12, 536 235, 4353201, 435325, 514 44 R, 424 932, 435 696, 435 691
Abstract:
The invention includes cysteine-modified PSMA polypeptides and disulfide-bond-stabilized dimers thereof, compositions and kits containing the cysteine-modified PSMA polypeptides, including dimers thereof, as well as methods of producing and using these compositions. Such methods include methods for eliciting or enhancing an immune response to cells expressing PSMA, methods of producing antibodies to PSMA, including dimeric PSMA, as well as methods of treating cancer, such as prostate cancer.