Resumes
Resumes
Jyoti Disa Phones & Addresses
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321 Marielle Dr, King of Prussia, PA 19406 (610) 279-7397 (610) 962-9913
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Norristown, PA
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Kng Of Prussa, PA
Publications
Us Patents
Nucleic Acid Encoding A Bovine Calcitonin Receptor-Like Receptor (Becrlr)
View pageUS Patent:
60748451, Jun 13, 2000
Filed:
Jan 28, 1999
Appl. No.:
9/238796
Inventors:
Nambi V. Aiyar - Berwyn PA
Jyoti Disa - King of Prussia PA
Jyoti Disa - King of Prussia PA
Assignee:
SmithKline Beecham Corporation - Philadelphia PA
International Classification:
C12N 1512
C12N 510
C12N 1563
C07K 14705
C12N 510
C12N 1563
C07K 14705
US Classification:
435 691
Abstract:
BECRLR polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing BECRLR polypeptides and polynucleotides in screening assays to discover compounds that either agonize or antagonize the biological activity of the receptor. Such compounds are expected to be useful in treatment of human diseases, including, but not limited to: infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; diabetes, obesity; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; stroke; ulcers; asthma; allergies; benign prostatic hypertrophy; migraine; vomiting; psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, depression, delirium, dementia, and severe mental retardation; and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome.