US Patent:
20040048256, Mar 11, 2004
Inventors:
Michele Agee - Wallingford CT, US
John Alsobrook - Madison CT, US
David Anderson - Branford CT, US
Constance Berghs - New Haven CT, US
Ferenc Boldog - North Haven CT, US
Catherine Burgess - Wethersfield CT, US
Stacie Casman - North Haven CT, US
Elina Catterton - Madison CT, US
John Chant - Branford CT, US
Amitabha Chaudhuri - Madison CT, US
Julie Bokor - Gainesville FL, US
Vincent DiPippo - East Haven CT, US
Shlomit Edinger - New Haven CT, US
Andrew Eisen - Rockville MD, US
Karen Ellerman - Branford CT, US
Esha Gangolli - Madison CT, US
Valerie Gerlach - Branford CT, US
Loic Giot - Madison CT, US
Linda Gorman - Branford CT, US
Xiaojia Guo - Branford CT, US
Vladimir Gusev - Madison CT, US
Weizhen Ji - Branford CT, US
Ramesh Kekuda - Norwalk CT, US
Nikolai Khramtsov - Branford CT, US
Martin Leach - Madison CT, US
Denise Lepley - Branford CT, US
Li Li - Branford CT, US
Xiaohong Liu - Lexington MA, US
Uriel Malyankar - Branford CT, US
Charles Miller - Guilford CT, US
Chean Ooi - Branford CT, US
Tatiana Ort - Milford CT, US
Muralidhara Padigaru - Branford CT, US
Meera Patturajan - Branford CT, US
Carol Pena - Guilford CT, US
Daniel Rieger - Branford CT, US
Mark Rothenberg - Clinton CT, US
Suresh Shenoy - Branford CT, US
Richard Shimkets - Guilford CT, US
Steven Spaderna - Berlin CT, US
Kimberly Spytek - New Haven CT, US
Raymond Taupier - East Haven CT, US
Nancy Twomlow - Madison CT, US
Corine Vernet - Branford CT, US
Edward Voss - Wallingford CT, US
Bryan Zerhusen - Branford CT, US
Mei Zhong - Branford CT, US
International Classification:
C12Q001/68
C07H021/04
C12N009/00
C07K014/47
C12P021/02
C12N005/06
US Classification:
435/006000, 435/069100, 435/183000, 435/320100, 435/325000, 530/350000, 536/023200, 514/012000
Abstract:
The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
