Inventors:
Robert G. Roeder - New York NY
Joseph D. Fondell - Baltimore MD
Chao Xingyuan - New York NY
Mitsuhiro Ito - New York NY
Assignee:
The Rockefeller University - New York NY
International Classification:
C12Q 168
Abstract:
Isolated nucleic acid molecules encoding Thyroid Receptor-Associated Proteins (TRAPS) are provided. TRAPS are members of protein complexes that bind to nuclear hormone receptors in a ligand-dependent manner so that the receptor, upon activation by a corresponding hormone, regulates the transcription of a particular gene. Also provided are methods of replicating and expressing such isolated nucleic acid molecules, pharmaceutical compositions comprising TRAPS, and methods of modulating gene expression via administration of therapeutically effective amounts of such pharmaceutical compositions.