Inventors:
JOSEPH M. DIRIENZO - Drexel Hill PA, US
International Classification:
A61K 39/395
C12N 15/62
C12N 15/63
C12N 5/09
C07K 14/195
C07K 19/00
C12N 15/31
A61P 35/00
A61P 31/10
A61K 31/7088
C12N 9/96
A61K 38/46
US Classification:
4241831, 435188, 536 232, 4353201, 435375, 424 943, 5303917, 536 237, 514 44 R, 530350
Abstract:
This invention provides, a recombinant polypeptide encoding a chimera. The chimera includes a DNase I fragment or a homologue thereof and a Cdt fragment or a homologue thereof. Further, the invention provides methods, utilizing the recombinant polypeptide encoding the chimera, such as a method for inhibiting the proliferation of a neoplastic cell, a method for treating a neoplastic disease in a human subject, a method for inhibiting or suppressing a neoplastic disease in a human subject, and a method for reducing the symptoms associated with a neoplastic disease in a human subject.