US Patent:
20090048153, Feb 19, 2009
Inventors:
Shambhu D. Varma - Ellicott City MD, US
John Petrali - Churchville MD, US
Assignee:
UNIVERSITY OF MARYLAND, BALTIMORE - Baltimore MD
The Government of the United States, as represented by the Secretary of the Army - Fort Detrick MD
International Classification:
A61K 38/28
A61K 31/185
A01N 37/12
A61K 31/405
A61K 31/56
A61K 31/355
A61K 31/7004
US Classification:
514 4, 514578, 514 23, 514563, 514458, 514420, 514183
Abstract:
One embodiment of the present invention provides a composition, comprising, in amounts effective to treat sulfur mustard or half sulfur mustard induced toxicity or skin damage: an agent that inhibits alkylation of —SH and >NH protein groups; an agent that reduces —SS— to SH; a scavenger of reactive oxygen species; a substrate that maintains tissue reduction-oxidation status; an agent that protects against invading inflammatory cells and associated oxidative stress; an antagonist of prostaglandin synthesis; and an agent that induces tissue regeneration. Methods of using the composition are also provided.