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John D Macmicking

from Stamford, CT
Age ~60
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Also known as:
John Mac
Phone and address:
108 Forest St, Stamford, CT 06901
(203) 969-7194
Connected to:
Aaron K Macmillan, 62Alfred R Macmillan, 69Ann Macmillan, 89Anna R Macmillan, 104Anne B Macmillan, 89Austin J Macmillan, 28Bethany T Macmillan, 30Bill Y Macmillan, 79Brendan S Macmillan, 56Cam Macmillan, 63

John Macmicking Phones & Addresses

  • 108 Forest St, Stamford, CT 06901 (203) 969-7194
  • New York, NY
  • Bridgeport, CT

Publications

Us Patents

Transgenic Mouse Deficient In Inducible Nitric Oxide Synthase

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US Patent:
58500049, Dec 15, 1998
Filed:
Feb 28, 1997
Appl. No.:
8/808191
Inventors:
John MacMicking - New York NY
Carl Nathan - Larchmont NY
John S. Mudgett - Scotch Plains NJ
Assignee:
Cornell Research Foundation, Inc. - Ithaca NY
Merck & Co., Inc. - Rahway NJ
International Classification:
C12N 500
C12N 1500
A61K 4900
US Classification:
800 2
Abstract:
The present invention provides an inducible nitric oxide synthase ("iNOS")-deficient transgenic mouse, novel replacement vectors designed for the disruption of the iNOS gene, embryonic stem (ES) cells which are singly allelic relative to the deficient iNOS locus, a host cell line or cell clone carrying a congenitally altered iNOS gene, and a method of producing such a transgenic mouse. The iNOS-deficient transgenic mice can be used to evaluate and/or test their susceptibility to infectious or tumorigenic challenge, autoimmunity, septic shock and inflammatory and allergic diseases.
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John D Macmicking from Stamford, CT, age ~60 Get Report