Inventors:
Ulla Hansen - Bedford MA, US
Scott Schaus - Boston MA, US
Trevor Grant - Allston MA, US
Joshua Bishop - Southborough MA, US
John Kavouris - Pittsburgh PA, US
Lisa M. Christadore - Pequannock NJ, US
Assignee:
TRUSTEES OF BOSTON UNIVERSITY - Boston MA
International Classification:
A61K 31/4741
A61K 31/4704
US Classification:
514291, 546 90, 514312, 546158
Abstract:
The present invention is directed to methods, compositions and kits for treatment of cancer, e.g. heptacellular carcinoma. In some embodiments, the present invention discloses the use of a small-molecule compound of formulas (I)-(XXVI) as disclosed herein to inhibit transcription factor Late SV40 Factor (LSF) for treatment of cancer, e.g., HCC.