Inventors:
Nicholas D. Adams - Collegeville PA, US
Joelle Lorraine Burgess - Collegeville PA, US
Michael Gerard Darcy - Collegeville PA, US
Carla A. Donatelli - Collegeville PA, US
Steven David Knight - Collegeville PA, US
Kenneth Allen Newlander - Collegeville PA, US
Lance Ridgers - Collegeville PA, US
Martha A. Sarpong - Collegeville PA, US
Stanley J. Schmidt - Collegeville PA, US
Assignee:
GlaxoSmithKline LLC - Philadelph PA
International Classification:
C07D 401/14
C07D 413/14
C07D 498/04
Abstract:
Invented is a method of inhibiting the activity/function of PI3 kinases using quinoline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoline derivatives.