Jeffrey S Campbell

6342639, Jan 29, 2002

Jun 17, 1999

09/335447

Jeffrey Allen Campbell - Fremont CA
Lawrence Emerson Fisher - Mountain View CA
Charles Alois Dvorak - Palo Alto CA
Paul Leo McGrane - Mountain View CA

Syntex (U.S.A.) LLC - Palo Alto CA

C07C32106

568 52, 568 56, 568 58

This invention provides processes for the preparation of a compound of Formula I: wherein: Y is hydroxy or XONX, where each X is independently hydrogen, lower alkyl or lower acyl; R is hydrogen or lower alkyl; R is hydrogen, lower alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, or R and R together with the carbon atom to which they are attached form a cycloalkyl or heterocyclo group; R is aryl; and n is 0, 1 or 2. The invention also provides novel aryl haloalkyl sulfide intermediates useful for the preparation of compounds of Formula I and novel methods of preparing aryl alkyl sulfides.

6376506, Apr 23, 2002

Dec 22, 1999

09/469677

Chris Allen Broka - Foster City CA
Jeffrey Allen Campbell - Cheshire CT
Arlindo Lucas Castelhano - New City NY
Jian Jeffrey Chen - Santa Clara CA
Robert Than Hendricks - Palo Alto CA
Michael Joseph Melnick - Ann Arbor MI
Keith Adrian Murray Walker - Los Altos Hills CA

Syntex (U.S.A.) LLC - Palo Alto CA
Agouron Pharmaceuticals, Inc. - La Jolla CA

A61K 31435

514292, 546 87

This invention relates to sulfamides of formula (I) that are inhibitors of metalloproteases, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.

6420573, Jul 16, 2002

Nov 9, 2001

09/991143

Jeffrey Allen Campbell - Fremont CA
Lawrence Emerson Fisher - Mountain View CA
Charles Alois Dvorak - Palo Alto CA
Paul Leo McGrane - Mountain View CA

Syntex (U.S.A.) LLP - Palo Alto CA

C07D30906

549425, 549426, 549427, 564300, 568 52, 568 56, 568 58

This invention provides processes for the preparation of a compound of Formula I: wherein: Y is hydroxy or XONX, where each X is independently hydrogen, lower alkyl or lower acyl; R is hydrogen or lower alkyl; R is hydrogen, lower alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, or R and R together with the carbon atom to which they are attached form a cycloalkyl or heterocyclo group; R is aryl; and n is 0, 1 or 2. The invention also provides novel aryl haloalkyl sulfide intermediates useful for the preparation of compounds of Formula I and novel methods of preparing aryl alkyl sulfides.

6492394, Dec 10, 2002

Dec 22, 1999

09/469660

Chris Allen Broka - Foster City CA
Jeffrey Allen Campbell - Fremont CA
Jian Jeffrey Chen - Santa Clara CA
Sharon Marie Dankwardt - Foster City CA
Nancy Delaet - San Diego CA
Leslie Ann Robinson - Los Altos CA
Keith Adrian Murray Walker - Los Altos CA

Syntex (U.S.A.) LLC - Palo Alto CA

A61K 31445

514321, 5142275, 5142278, 5142282, 5142312, 5142338, 5142345, 5142352, 5142355, 514255, 514311, 514314, 514318, 514322, 514323, 514326, 514337, 514338, 514339, 514394, 514412, 514419, 514422, 514438, 514443, 514464, 544 584, 544124, 544128, 544139, 544143, 544153, 544159, 544363, 544370, 544373, 544377, 544386, 546193, 546197, 546199, 546201, 546229, 546264, 5462734, 5462774, 548495, 548517, 548518, 548561, 549 59, 549 75, 549 76, 549 77, 549440, 549448, 549452

A compound of the Formula (I): wherein Z, R , R, and Ar are as defined in the specification. This invention also relates to sulfonamide compounds of the Formula (I) that are inhibitors of procollagen C-proteinase, pharmaceutical compositions containing them, methods for their use, and methods for preparing the compounds.

6787559, Sep 7, 2004

Oct 9, 2002

10/267727

Chris Allen Broka - Foster City CA
Jeffrey Allen Campbell - Fremont CA
Jian Jeffrey Chen - Santa Clara CA
Sharon Marie Dankwardt - Foster City CA
Nancy Delaet - San Diego CA
Leslie Ann Robinson - Los Altos CA
Keith Adrian Murray Walker - Los Altos CA

Syntex (U.S.A.) LLC. - Palo Alto CA

A61K 31445

514321, 5142275, 5142278, 5142282, 5142312, 5142338, 5142345, 514318, 514338, 514394, 514412, 514419, 514422, 514443, 514464, 546193, 546197, 546201, 546229, 5462734, 5462774, 549440, 549448, 549452

This invention relates to certain sulfonamide derivatives that are inhibitors of procollagen C-proteinase, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.

6844366, Jan 18, 2005

Oct 9, 2002

10/267292

Chris Allen Broka - Foster City CA, US
Jeffrey Allen Campbell - Fremont CA, US
Jian Jeffrey Chen - Santa Clara CA, US
Sharon Marie Dankwardt - Foster City CA, US
Nancy Delaet - San Diego CA, US
Leslie Ann Robinson - Los Altos CA, US
Keith Adrian Murray Walker - Los Altos CA, US

Syntex (U.S.A.) LLC - Palo Alto CA

A61K 31165
C07C25904

514575, 5142222, 5142378, 514255, 514331, 514357, 514438, 544 59, 544106, 544398, 546229, 546266, 549 74, 549623

This invention relates to certain sulfonamide derivatives that are inhibitors of procollagen C-proteinase, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.

6872744, Mar 29, 2005

Sep 26, 2002

10/255891

Chris Allen Broka - Foster City CA, US
Jeffrey Allen Campbell - Cheshire CT, US

Syntex (U.S.A.) LLC - Palo Alto CA

A61K031/40
C07D209/36

514418, 548484

This invention relates to compounds, which are generally anti-inflammatory and analgesic compounds, and which are represented by Formula I: wherein A is a —CH—, —O—, —S—, or —S(O)—; and the other substituents are as defined in the specification; or individual isomers, mixtures of isomers, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents.

7074939, Jul 11, 2006

Feb 25, 2005

11/065841

Chris Allen Broka - Foster City CA, US
Jeffrey Allen Campbell - Cheshire CT, US

Roche Palo Alto LLC - Palo Alto CA

C07D 209/36

548484

This invention relates to compounds, which are generally anti-inflammatory and analgesic compounds, and which are represented by Formula I:.