Jason P Dexter

20090155871, Jun 18, 2009

Jan 16, 2007

12/160770

Pengcheng Patrick Fu - Honolulu HI, US
Jason Dexter - Honolulu HI, US

UNIVERSITY OF HAWAII - Honolulu HI

C12P 7/06
C12N 15/11
C12N 15/00
C12N 1/21

435161, 536 232, 4353201, 4352523

The present invention relates to methods and systems for the production of ethanol by cyanobacteria. More specifically, the methods can be used to produce ethanol using genetically engineered light responsive cyanobacteria.

20190263871, Aug 29, 2019

Jul 20, 2017

16/307783

Jason DEXTER - Olean NY, US

C07K 14/195
C12N 1/12
C12N 9/50
C12N 15/52
C12N 1/20
C12N 15/03
C12N 15/82

The invention comprises a photoautotrophic organism, generally having simpler nutritional requirements than heterotrophic organisms, utilized as a chassis for the heterologous expression and function of enzymes, or derivatives of said enzymes, that show activity toward the degradation/detoxification of toxins known to be associated with and specific to harmful algal blooms. As an example, a cyanobacterial strain (sp. PCC 6803) modified to express sp. USTB-05 MlrA enzyme functionality, showing the capability of degrading microcystins (results shown here) and nodularins, is presented. Under modelled natural conditions, results indicate that heterologous enzymatic activity against microcystin-LR is more stable over time when utilizing a photoautotrophic chassis in comparison to use of a heterotrophic bacterial strain. In addition, both the viability and cell density of the photoautotrophic host is maintained for a significantly longer period of time, compared to a heterotrophic host.