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James R Brookeman

from Charlottesville, VA
Age ~84
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Also known as:
James B Brookeman, James Brokeman
Phone and address:
1800 Dairy Rd, Charlottesville, VA 22903
(434) 979-3724
Related to:
James Joseph Mcdermott, 75Katharine A Brookeman, 48
Connected to:
Constance M Brookens, 70Gary N Brookens, 69Holly A Brookens, 38Norris E Brookens, 95Rebecca E Brookens, 53Richard R Brookens, 71Andy M Brooker, 74Asa G Brooker, 29Ashley C Brookes, 36Bradley K Brookes, 62

James Brookeman Phones & Addresses

  • 1800 Dairy Rd, Charlottesvle, VA 22903 (434) 979-3724
  • 1929 Lewis Mountain Rd, Charlottesville, VA 22903 (804) 979-3724
  • Key Biscayne, FL
  • Gainesville, FL

Work

Company: University of virginia Position: Prof

Education

Degree: Bsc, PhD School / High School: University of St. Andrews 1960 to 1968 Specialities: Physics, NMR,MRI

Industries

Higher Education

Resumes

Resumes

James Brookeman Photo 1

Professor

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Location:
Charlottesville, VA
Industry:
Higher Education
Work:
University of Virginia
Prof
Education:
University of St. Andrews 1960 - 1968
Bsc, PhD, Physics, NMR,MRI

Publications

Us Patents

Diagnostic Procedures Using Direct Injection Of Gaseous Hyperpolarized 129Xe And Associated Systems And Products

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US Patent:
6630126, Oct 7, 2003
Filed:
Mar 12, 2001
Appl. No.:
09/804369
Inventors:
Bastiaan Driehuys - Durham NC
Dennis Fujii - Downingtown PA
James R. Brookeman - Charlottesville VA
Klaus D. Hagspiel - Charlottesville VA
Assignee:
Medi-Physics, Inc. - Princeton NJ
University of Virginia Patent Foundation - Charlottesville VA
International Classification:
A61B 5055
US Classification:
424 93, 600420
Abstract:
A method of screening for pulmonary embolism uses gaseous phase polarized Xe which is injected directly into the vasculature of a subject. The gaseous Xe can be delivered in a controlled manner such that the gas substantially dissolves into the vasculature proximate to the injection site. Alternatively, the gas can be injected such that it remains as a gas in the bloodstream for a period of time (such as about 8-29 seconds). The injectable formulation of polarized Xe gas is presented in small quantities of (preferably isotopically enriched) hyperpolarized Xe and can provide high-quality vasculature MRI images or NMR spectroscopic signals with clinically useful signal resolution or intensity. One method injects the polarized Xe as a gas into a vein and also directs another quantity of polarized gas into the subject via inhalation. In this embodiment, the perfusion uptake allows arterial signal information and the injection (venous side) allows venous signal information.

Exchange-Based Nmr Imaging And Spectroscopy Of Hyperpolarized Xenon-129

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US Patent:
6775568, Aug 10, 2004
Filed:
Apr 12, 2001
Appl. No.:
09/832880
Inventors:
Kai Ruppert - Santa Rosa CA
James R. Brookeman - Charlottesville VA
Assignee:
University of Virginia Patent Foundation - Charlottesville VA
International Classification:
A61B 505
US Classification:
600410, 600420, 324313, 424 93
Abstract:
A method and an apparatus for using hyperpolarized xenon-129 and magnetic resonance imaging or spectroscopy as a probe to non-invasively and non-destructively characterize important properties of certain structures or materials with high spatial and temporal resolution, resulting in high-resolution magnetic resonance images wherein the associated signal intensities reflect a property of interest of at least one of the compartments. Hyperpolarized xenon-129 is introduced into two compartments between which xenon-129 can be exchanged, for example, into the blood vessels of mammal organs and the tissue of said organ or into compartments within inorganic objects. Due to chemical shift and applied magnetic field strength, the hyperpolarized xenon-129 introduced into the first compartment has a different resonant frequency from the hyperpolarized xenon-129 introduced into the second compartment.

Method And System For Rapid Magnetic Resonance Imaging Of Gases With Reduced Diffusion-Induced Signal Loss

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US Patent:
7034533, Apr 25, 2006
Filed:
May 14, 2003
Appl. No.:
10/514272
Inventors:
James R. Brookeman - Charlottesville VA, US
Assignee:
University of Virginia Patent Foundation - Charlottesville VA
International Classification:
G01V 3/00
US Classification:
324318, 324309
Abstract:
A methodology, system and computer program product for designing and optimizing a rapid magnetic resonance imaging pulse sequence for creating images of a gas or gas-filled structure with substantially reduced diffusion-induced signal attenuation during the course of data acquisition compared to that for currently available magnetic resonance imaging techniques is disclosed. The methodology and system allows desirable combinations of image signal-to-noise ration, spatial resolution and temporal resolution to be achieved that were heretofore not possible. For example, magnetic resonance imaging of hyperpolarized noble gases, which recently has shown significant promise for several medical imaging applications, particularly imaging of the human lung, can be improved. Pulse sequences designed according to the subject methods permit signal levels to be achieved that are up to ten times higher than those possible with the gradient-echo methods now commonly used for hyperpolarized-gas imaging. This signal increase can be traded for substantially lower does, and hence much lower cost, of the hyperpolarized-gas agent.

Method And Apparatus For Spin-Echo-Train Mr Imaging Using Prescribed Signal Evolutions

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US Patent:
7164268, Jan 16, 2007
Filed:
Dec 21, 2001
Appl. No.:
10/451124
Inventors:
James R. Brookeman - Charlottesville VA, US
Assignee:
University of Virginia Patent Foundation - Charlottesville VA
International Classification:
G01V 3/00
A61B 5/055
US Classification:
324307, 600410, 600413, 600428, 324309, 324318
Abstract:
A magnetic resonance imaging “MRI” method and apparatus for lengthening the usable echo-train duration and reducing the power deposition for imaging is provided. The method explicitly considers the t1 and t2 relaxation times for the tissues of interest, and permits the desired image contrast to be incorporated into the tissue signal evolutions corresponding to the long echo train. The method provides a means to shorten image acquisition times and/or increase spatial resolution for widely-used spin-echo train magnetic resonance techniques, and enables high-field imaging within the safety guidelines established by the Food and Drug Administration for power deposition in human MRI.

Optimized High-Speed Magnetic Resonance Imaging Method And System Using Hyperpolarized Noble Gases

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US Patent:
7174200, Feb 6, 2007
Filed:
Apr 12, 2002
Appl. No.:
10/474571
Inventors:
Michael Salerno - Palo Alto CA, US
James R. Brookeman - Charlottesville VA, US
Assignee:
University of Virginia Patent Foundation - Charlottesville VA
International Classification:
B61B 5/05
US Classification:
600420, 600431, 600407, 424 93
Abstract:
A system and method for using hyperpolarized noble gases together with an appropriately designed and optimized magnetic resonance imaging pulse sequence to rapidly acquire static or dynamic magnetic resonance images. The strong magnetic resonance signal from hyperpolarized gases, combined with the present magnetic resonance imaging technique, presents the opportunity for the imaging of gases with both high spatial and high temporal resolution. One potential application for such a method is the direct, dynamic visualization of gas flow, which would be extremely useful for characterizing a variety of fluid systems. In the medical field, one such system of substantial importance is the lung. The system and method provides for visualizing regional ventilatory patterns throughout the respiratory cycle with high temporal and high spatial resolution. The low sensitivity to susceptibility artifacts permits good image quality to be obtained in various orientations. Depending on the application, temporal resolution can be traded for anatomical coverage.

Exchange-Weighted Xenon-129 Nuclear Magnetic Resonance System And Related Method

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US Patent:
7805176, Sep 28, 2010
Filed:
Mar 9, 2005
Appl. No.:
10/592200
Inventors:
Kai Ruppert - Havertown PA, US
James R. Brookeman - Charlottesville VA, US
Assignee:
University of Virginia Patent Foundation - Charlottesville VA
International Classification:
A61B 5/05
US Classification:
600407, 600409, 600410
Abstract:
Method and system that provides, among other things, the capability for using hyperpolarized xenon-129 as a probe to non-invasively and non-destructively characterize important properties of certain structures or materials into which hyperpolarized xenon-129 can be introduced and wherein the xenon exists in two or more chemically-shifted states that are in exchange High-resolution MR images can be generated in a fraction of a second wherein the associated signal intensities reflect material properties that characterize the gas exchange among the different states. For example, in the human or animal lung, the system and related method can exploit the differences in gas-exchange characteristics between healthy and diseased lung tissue to generate high-resolution, high signal-to-noise cross-sectional MR images that permit non-invasive regional detection of variations in lung tissue structure with a combination of spatial and temporal resolution that is unmatched by any current imaging modality.

Method And Apparatus For Spin-Echo-Train Mr Imaging Using Prescribed Signal Evolutions

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US Patent:
RE44644, Dec 17, 2013
Filed:
Jan 15, 2009
Appl. No.:
12/354471
Inventors:
James R. Brookeman - Charlottesville VA, US
Assignee:
University of Virginia Patent Foundation - Charlottesville VA
International Classification:
G01R 33/50
A61B 5/055
G01V 3/00
US Classification:
324307, 324314, 324309, 324318, 600410, 600413, 600425, 600428
Abstract:
A magnetic resonance imaging “MRI” method and apparatus for lengthening the usable echo-train duration and reducing the power deposition for imaging is provided. The method explicitly considers the t1 and t2 relaxation times for the tissues of interest, and permits the desired image contrast to be incorporated into the tissue signal evolutions corresponding to the long echo train. The method provides a means to shorten image acquisition times and/or increase spatial resolution for widely-used spin-echo train magnetic resonance techniques, and enables high-field imaging within the safety guidelines established by the Food and Drug Administration for power deposition in human MRI.

System And Method For Improved Detection And Assessment Of Changes In Lung-Tissue Structure

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US Patent:
20070197903, Aug 23, 2007
Filed:
Mar 9, 2005
Appl. No.:
10/592186
Inventors:
John Mugler - Charlottesville VA, US
James Brookeman - Charlottesville VA, US
Jaime Mata - Richmond VA, US
Talissa Altes - Philadelphia PA, US
International Classification:
A61B 5/05
US Classification:
600420000
Abstract:
A method and system is described for measuring the apparent diffusion coefficient of Xe129 in the lung as a means to detect and assess changes in lung-tissue structure such as those that occur in certain pulmonary diseases. The main steps of this process include: polarizing the Xe129 gas; introducing said gas into the lung; acquiring sets of Xe 129 M R signals with various diffusion sensitizations; calculating Xe 129 ADC values; and evaluating said ADC values by comparison of the values in a region of interest to those in different regions of the lung or to normative values.
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James R Brookeman from Charlottesville, VA, age ~84 Get Report