US Patent:
20190256842, Aug 22, 2019
Inventors:
- Cambridge MA, US
Jacob Charles Carlson - Somerville MA, US
Ahmed Hussein Badran - Somerville MA, US
Kevin Michael Esvelt - Cambridge MA, US
Assignee:
President and Fellows of Harvard College - Cambridge MA
International Classification:
C12N 15/10
C40B 50/06
C40B 10/00
C12N 15/01
C12N 7/00
Abstract:
Strategies, systems, methods, reagents, and kits for phage-assisted continuous evolution are provided herein. These include strategies, systems, methods, reagents, and kits allowing for stringency modulation to evolve weakly active or inactive biomolecule variants, negative selection of undesired properties, and/or positive selection of desired properties.