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Howard H Bengele

from Hingham, MA
Age ~87
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Also known as:
Howard H Benegel, Howard H Bengel, Bengele Howard, Howard E
Phone and address:
207 Linden Ponds Way UNIT T33, Hingham, MA 02043
(781) 749-2478
Connected to:
Paul B Bengelink, 46Howard E Bengelsdorf, 75Christopher A Benger, 44James M Benger, 41John G Benger, 68Laura A Bengero, 62Ryan Bengert, 98Cheryl A Bengford, 60Joanna J Bengford, 55Jack D Benggio, 53

Howard Bengele Phones & Addresses

  • 207 Linden Ponds Way UNIT T33, Hingham, MA 02043 (781) 749-2478
  • 207 Linden Ponds Way, Hingham, MA 02043
  • 5 Historical Way, Canton, MA 02021
  • 207 Linden Ponds Way UNIT T33, Hingham, MA 02043

Resumes

Resumes

Howard Bengele Photo 1

Howard Bengele

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Location:
Hingham, MA
Industry:
Pharmaceuticals
Work:
Amag Pharmaceuticals 1984 - 2001
Director Pharmacology and Toxicology
Howard Bengele Photo 2

Howard Bengele

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Location:
Hingham, MA
Industry:
Telecommunications
Work:
Linde Pods
Retired

Publications

Us Patents

Heat Stable Colloidal Iron Oxides Coated With Reduced Carbohydrates And Uses Thereof

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US Patent:
7553479, Jun 30, 2009
Filed:
Mar 11, 2003
Appl. No.:
10/386394
Inventors:
Ernest V. Groman - Brookline MA, US
Kenneth G. Paul - Holliston MA, US
Timothy B. Frigo - Waltham MA, US
Howard Bengele - Canton MA, US
Jerome M. Lewis - Newton MA, US
Assignee:
AMAG Pharmaceuticals, Inc. - Cambridge MA
International Classification:
A61B 5/055
A61K 49/00
A61K 33/26
A61K 31/70
A61K 31/715
US Classification:
424 93, 424 9351, 424646, 424647, 424648, 514 23, 514 54, 514 59
Abstract:
Compositions, methods of making the compositions, and methods of using the compositions are provided for an enhanced magnetic resonance imaging agent and a hematinic agent, the agents comprising carboxyalkylated reduced polysaccharides coated ultrasmall superparamagnetic iron oxides. Methods of use of the carboxymethyl reduced dextran as a plasma extender are provided.

Polyol And Polyether Iron Oxide Complexes As Pharmacological And/Or Mri Contrast Agents

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US Patent:
7871597, Jan 18, 2011
Filed:
Apr 9, 2003
Appl. No.:
10/410527
Inventors:
Ernest V. Groman - Brookline MA, US
Kenneth G. Paul - Holliston MA, US
Timothy B. Frigo - Waltham MA, US
Howard Bengele - Canton MA, US
Jerome M. Lewis - Newton MA, US
Assignee:
AMAG Pharmaceuticals, Inc. - Lexington MA
International Classification:
A61B 5/055
A01N 43/04
A61K 31/715
US Classification:
424 93, 424 9351, 514 23, 514 54, 514 59
Abstract:
Pharmacological compositions, and methods for administration, of the type employing an iron oxide complex with a polyol or polyether. The methods of administration may comprise parenteral administration of an effective dose of the complex formulated in a biocompatible liquid delivered at a rate of from about 1 mL/sec to less than 1 mL/min and wherein upon administration the complex provides minimal detectable free iron in a subject, and minimal incidence of anaphylaxis. The pharmacological compositions are of the type employing a polyol or polyether iron oxide complex, which, upon parenteral administration to a subject, are substantially immunosilent, provide minimal anaphylaxis and minimal free iron, and undergo minimal dissolution in vivo.

Polyol And Polyether Iron Oxide Complexes As Pharmacological And/Or Mri Contrast Agents

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US Patent:
8501158, Aug 6, 2013
Filed:
Dec 8, 2010
Appl. No.:
12/963308
Inventors:
Ernest V. Groman - Brookline MA, US
Kenneth G. Paul - Holliston MA, US
Timothy B. Frigo - Waltham MA, US
Howard Bengele - Canton MA, US
Jerome M. Lewis - Mewton MA, US
Assignee:
AMAG Pharmaceuticals, Inc. - Lexington MA
International Classification:
A61B 5/055
A01N 43/04
A61K 31/715
US Classification:
424 93, 424 9351, 514 23, 514 54, 514 59
Abstract:
Pharmacological compositions, and methods for administration, of the type employing an iron oxide complex with a polyol or polyether. The methods of administration may comprise parenteral administration of an effective dose of the complex formulated in a biocompatible liquid delivered at a rate of from about 1 mL/sec to less than 1 mL/min and wherein upon administration the complex provides minimal detectable free iron in a subject, and minimal incidence of anaphylaxis. The pharmacological compositions are of the type employing a polyol or polyether iron oxide complex, which, upon parenteral administration to a subject, are substantially immunosilent, provide minimal anaphylaxis and minimal free iron, and undergo minimal dissolution in vivo.

Polyol And Polyether Iron Oxide Complexes As Pharmacological And/Or Mri Contrast Agents

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US Patent:
8591864, Nov 26, 2013
Filed:
Jan 4, 2013
Appl. No.:
13/734339
Inventors:
Kenneth G. Paul - Holliston MA, US
Timothy B. Frigo - Waltham MA, US
Howard Bengele - Canton MA, US
Jerome M. Lewis - Newton MA, US
Assignee:
AMAG Pharmaceuticals, Inc. - Lexington MA
International Classification:
A61B 5/055
A01N 43/04
A61K 31/715
US Classification:
424 93, 424 9351, 514 23, 514 54, 514 59
Abstract:
Iron oxide complexes, pharmacological compositions and unit dosage thereof, and methods for their administration, of the type employing an iron oxide complex with a polyol, are disclosed. The pharmacological compositions employ a polysaccharide iron oxide complex, wherein the polysaccharide is a modified polyol such as a carboxyalkylated reduced dextran. The complex is stable to terminal sterilization by autoclaving. The compositions are suitable for parenteral administration to a subject for the treatment of iron deficiencies or as MRI contrast agent. The complex is substantially immunosilent, provide minimal anaphylaxis and undergo minimal dissolution in vivo. The pharmacological compositions of the complex contain minimal free iron which can be quantified by a variety of methods.

Heat Stable Colloidal Iron Oxides Coated With Reduced Carbohydrates And Carbohdrate Derivatives

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US Patent:
6599498, Jul 29, 2003
Filed:
Mar 8, 2000
Appl. No.:
09/521264
Inventors:
Ernest V. Groman - Brookline MA
Kenneth G. Paul - Holliston MA
Timothy B. Frigo - Waltham MA
Howard Bengele - Canton MA
Jerome M. Lewis - Newton MA
Assignee:
Advanced Magnetics, Inc. - Cambridge MA
International Classification:
A61B 5055
US Classification:
424 934, 424 935, 424493, 514 54, 514 59
Abstract:
Compositions, methods of making the compositions, and methods of using the compositions are provided for an enhanced magnetic resonance imaging agent and a hematinic agent, the agents comprising carboxyalkylated reduced polysaccharides coated ultrasmall superparamagnetic iron oxides. Methods of use of the carboxymethyl reduced dextran as a plasma extender are provided.

Polyol And Polyether Iron Oxide Complexes As Pharmacological And/Or Mri Contrast Agents

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US Patent:
20140296509, Oct 2, 2014
Filed:
Jun 11, 2014
Appl. No.:
14/301757
Inventors:
- , unknown
Kenneth G. Paul - Holliston MA, US
Timothy B. Frigo - Waltham MA, US
Howard Bengele - Canton MA, US
Jerome M. Lewis - Newton MA, US
International Classification:
A61K 49/12
US Classification:
536113
Abstract:
Iron oxide complexes, pharmacological compositions and unit dosage thereof, and methods for their administration, of the type employing an iron oxide complex with a polyol, are disclosed. The pharmacological compositions employ a polysaccharide iron oxide complex, wherein the polysaccharide is a modified polyol such as a carboxyalkylated reduced dextran. The complex is stable to terminal sterilization by autoclaving. The compositions are suitable for parenteral administration to a subject for the treatment of iron deficiencies or as MRI contrast agent. The complex is substantially immunosilent, provide minimal anaphylaxis and undergo minimal dissolution in vivo. The pharmacological compositions of the complex contain minimal free iron which can be quantified by a variety of methods.

Polyol And Polyether Iron Oxide Complexes As Pharmacological And/Or Mri Contrast Agents

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US Patent:
20140178310, Jun 26, 2014
Filed:
Jul 9, 2013
Appl. No.:
13/937923
Inventors:
- , unknown
Kenneth G. Paul - Holliston MA, US
Timothy B. Frigo - Waltham MA, US
Howard Bengele - Canton MA, US
Jerome M. Lewis - Newton MA, US
International Classification:
A61K 49/18
A61K 47/36
A61K 33/26
US Classification:
424 9323, 424647, 424493
Abstract:
Iron oxide complexes, pharmacological compositions and unit dosage thereof, and methods for their administration, of the type employing an iron oxide complex with a polyol, are disclosed. The pharmacological compositions employ a polysaccharide iron oxide complex, wherein the polysaccharide is a modified polyol such as a carboxyalkylated reduced dextran. The complex is stable to terminal sterilization by autoclaving. The compositions are suitable for parenteral administration to a subject for the treatment of iron deficiencies or as MRI contrast agent. The complex is substantially immunosilent, provide minimal anaphylaxis and undergo minimal dissolution in vivo. The pharmacological compositions of the complex contain minimal free iron which can be quantified by a variety of methods.
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Howard H Bengele from Hingham, MA, age ~87 Get Report