Inventors:
Joseph J. Ferretti - Oklahoma City OK
Horst Malke - Oklahoma City OK
Assignee:
Board of Regents of the University of Okla. - Norman OK
International Classification:
C12N 1500
C12N 970
C12N 120
C07H 1512
Abstract:
A recombinant vector adapted for transformation of a suitable microorganism host to produce and secrete streptokinase. The recombinant vector comprises a plasmid into which a polydeoxyribonucleotide fragment from Streptococcus equisimilis H46A which codes for streptokinase synthesis and secretion has been inserted. The transformant microorganism including this recombinant plasmid vector produces streptokinase suitable for clinical fibrinolytic usage after purification.