Gerard A Cangelosi

20120094285, Apr 19, 2012

Dec 10, 2009

13/133889

Gerard A Cangelosi - Seattle WA, US
John Scott Meschke - Bothell WA, US
Kris Weigel - Seattle WA, US

Seattle Biomedical Research Institute - Seattle WA
University of Washington - Seattle WA

C12Q 1/68

435 611, 435 615, 435 612

Disclosed are compositions and methods for detecting the presence of viable cells in a sample. Included are compositions and methods for increasing the sensitivity of a nucleic acid amplification test for determining the presence of at least one target microorganism in a sample. Also disclosed are compositions and methods for detecting ribosomal RNA precursors (pre-rRNA) as dynamic indicators of viable microorganisms in a sample.

57703736, Jun 23, 1998

Nov 8, 1996

8/745638

Theresa B. Britschgi - Seattle WA
Gerard A. Cangelosi - Seattle WA

Becton Dickinson and Company - Franklin Lakes NJ

C12Q 168

435 6

The invention relates to methods and oligonucleotide probe compositions useful for determining antibiotic resistance in Mycobacteria. Included are methods for freeing intact precursor ribosomal RNA from mycobacterial cells and for assaying the levels of pre-rRNA in the cells. Also claimed are methods useful in discovering new anti-mycobacterial therapeutic agents.

57766940, Jul 7, 1998

Jul 2, 1997

8/886999

Diana K. Sheiness - Bothell WA
Trevor H. Adams - Buckinghamshire, GB2
Michael R. Stamm - Bothell WA
Gerard A. Cangelosi - Seattle WA
Theresa B. Britschgi - Seattle WA
Connie K. Dix - Arlington WA

Becton Dickinson Company - Franklin Lakes NJ

C12Q 168
C07H 2104

435 6

The present invention relates, in general, to diagnostic kits for selectively detecting a prokaryotic microorganism and a eukaryotic microorganism in a sample wherein the cells of such microorganisms are lysed by combining the sample with a lysis solution and contacting the nucleic acid released from the microorganisms with selective nucleic acid probes through hybridization techniques. The present invention can be used for detecting microorganisms associated with vaginal disorders, e. g. , Gardnerella vaginalis, Trichomonas vaginalis and Candida albicans. These kits may be used in a medical practitioner's private office or in a more structured clinical environment, such as a hospital, a commercial clinical microbiology laboratory or the like.

57260214, Mar 10, 1998

Nov 27, 1996

8/757180

Theresa B. Britschgi - Seattle WA
Gerard A. Cangelosi - Seattle WA

Becton Dickinson and Company - Franklin Lakes NJ

C12Q 168
C12Q 100

435 6

The invention relates to methods and compositions useful for rapidly freeing precursor ribosomal RNA from mycobacterial cells. The methods and compositions further result in detectable levels of ribosomal RNA precursors that are not degraded.

59586893, Sep 28, 1999

May 21, 1997

8/861096

Christopher A. Scholin - Monterey CA
Gerard A. Cangelosi - Seattle WA
Paul V. Haydock - Seattle WA

Monterey Bay Aquarium Research Institute - Moss Landing CA

C12Q 168
C07H 2102
C07H 2104
C12N 1500

435 6

The present invention provides compositions, methods, and kits for detecting species of Pseudo-nitzschia from a marine sample. Oligonucleotide probes for rRNA hypervariable regions of the Psuedo-nitzschia species: P. australis, P. pungens, P. multiseries, P. pseudodelicatissima, P. heimii, P. fraudulenta, P. delicatissima, and P. americana are provided as well as a oligonucleotide probe for a conserved region of ribosomal RNA from Pseudo-nitzschia.

57120951, Jan 27, 1998

Jun 7, 1995

8/485602

Theresa B. Britschgi - Seattle WA
Gerard A. Cangelosi - Seattle WA

Becton Dickinson and Company - Franklin Lakes NJ

C12Q 168
C07H 2104
C07H 2102

435 6

The invention relates to methods and oligonucleotide probe compositions useful for determining antibiotic resistance in Mycobacteria. Included are methods for freeing intact precursor ribosomal RNA from mycobacterial cells and for assaying the levels of pre-rRNA in the cells. Also claimed are methods useful in discovering new anti-mycobacterial therapeutic agents.