Inventors:
Victor A. Cruz - Newark NJ
W. Michael Nichols - Fanwood NJ
Albert F. Sorg - Columbia NJ
George E. Tortarolo - Bridgewater NJ
William Bess - Edison NJ
Neema Kulkarni - Randolph NJ
Assignee:
Warner Lambert Company - Morris Plains NJ
International Classification:
A61K 3144
Abstract:
The present invention is directed to pharmaceutical compositions containing triprolidine and an ionic additive that improves the measured availability of the triprolidine in the tablet, as indicated by standard USP assay for triprolidine in pharmaceutical compositions. The invention also provides a process for producing compositions having improved triprolidine availability and a process for improving the performance of a pharmaceutical composition in a dissolution assay measuring triprolidine availability. The ionic additive can be, for example, an alkali metal salt, such as sodium chloride or potassium chloride.