George Thomas Mathai

20030224387, Dec 4, 2003

Dec 26, 2002

10/327868

Sandeep Kunwar - Hillsborough CA, US
Sobha Pisharody - Castro Valley CA, US
George Mathai - Castro Valley CA, US
Kristian Scaboo - Castro Valley CA, US

C12Q001/68
G01F001/64
G01N027/26
G01N033/50

435/006000, 205/777500

The present invention relates to a method for selectively modifying electrodes of an array of electrodes. The array of electrodes may be used as a sensor or biosensor to determine the presence of and/or identity of each of a plurality of analyte molecules. In accordance with the present invention, electrodes of each of a number N subsets of electrodes of an array of electrodes are contacted with a respective liquid, each of which comprises a respective, different molecule. For each subset of the N subsets of electrodes, at least one of the member electrodes is deprotected to allow molecules of the respective liquid to associate with the deprotected electrode. The steps of contacting subsets of electrodes and deprotecting selected electrodes is repeated until each electrode in the array has been associated with a predetermined molecule.

20040023253, Feb 5, 2004

Dec 26, 2002

10/335482

Sandeep Kunwar - Hillsborough CA, US
George Mathai - Castro Valley CA, US

C12Q001/68
C12M001/34

435/006000, 435/287200, 205/777500

A biosensor comprising a plurality of devices on a substrate. Each device in the plurality of devices occupying a different region on the substrate. Each device in the plurality of devices comprises a first electrically conducting material, a spacer, and a second electrically conducting material. The first electrically conducting material is overlaid on a first portion of the different region on the substrate occupied by a device and the spacer is overlaid on a second portion of the different region on the substrate that is occupied by the device. The first electrically conducting material and the spacer abut each other. The second electrically conducting material is overlaid on a portion of the spacer.

20040146863, Jul 29, 2004

Oct 2, 2001

09/970087

Sobha Pisharody - Dublin CA, US
Sandeep Kunwar - Redwood City CA, US
George Mathai - Dublin CA, US

C12Q001/68

435/006000, 205/777500

This invention provides novel sensors that facilitate the detection of essentially any analyte. In general, the biosensors of this invention utilize a binding agent (e.g. biomolecule) to specifically bind to one or more target analytes. In preferred embodiments, the biomolecules spans a gap between two electrodes. Binding of the target analyte changes conductivity of the sensor thereby facilitating ready detection of the binding event and thus detection and/or quantitation of the bound analyte. A molecular sensing apparatus comprising.

20040248282, Dec 9, 2004

Jul 16, 2004

10/480409

Kunwar Sandeep - Redwood City CA, US
George Mathai - Castro Valley CA, US

C12M001/34
C12Q001/68

435/287200, 435/006000

This invention provides novel sensors that facilitate the detection of essentially any analyte. In general, the biosensors of this invention utilize a binding agent (e.g. biomolecule) to specifically bind to one or more target analytes. In preferred embodiments, the biomolecules spans a gap between two electrodes. Binding of the target analyte changes conductivity of the sensor thereby facilitating ready detection of the binding event and thus detection and/or quantitation of the bound analyte.

20050130296, Jun 16, 2005

Sep 14, 2004

10/941176

Sobha Pisharody - Dublin CA, US
Sandeep Kunwar - Redwood City CA, US
George Mathai - Dublin CA, US

C12M001/34
C12Q001/68

435287200, 422082020, 435006000

This invention provides novel sensors that facilitate the detection of essentially any analyte. In general, the biosensors of this invention utilize a binding agent (e.g. biomolecule) to specifically bind to one or more target analytes. In preferred embodiments, the biomolecules spans a gap between two electrodes. Binding of the target analyte changes conductivity of the sensor thereby facilitating ready detection of the binding event and thus detection and/or quantitation of the bound analyte. A molecular sensing apparatus comprising.