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Frederick A Dombrose

from Charlotte, NC
Age ~79

Frederick Dombrose Phones & Addresses

  • 5220 Windfern Ct, Charlotte, NC 28226 (704) 543-1640 (704) 341-8558
  • Sylvania, OH
  • Chapel Hill, NC
  • Ventura, CA
  • Raleigh, NC
  • Lucas, OH
  • Miami, FL

Publications

Us Patents

Immunoassay For F1.2 Prothrombin Fragment

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US Patent:
6541275, Apr 1, 2003
Filed:
Feb 3, 1988
Appl. No.:
07/151735
Inventors:
Juan A. Ruiz - Miami FL
James R. Maynard - Miami FL
Frederick Dombrose - Ventura CA
Assignee:
Dade Behring Inc. - Deerfield IL
International Classification:
G01N 33543
US Classification:
436518, 435 74, 435 794, 436547, 436548, 5303879
Abstract:
According to the present invention highly specific-low affinity antibodies are generated which allow for the assay of F1. 2 in bodily fluids that also contain prothrombin or other plasma proteins. Antibodies having the necessary properties for this assay are made using synthetic polypeptides which mimic the carboxy terminus of F1. 2.

Immunoassays For And Monoclonal Antibodies To Prothrombin Activation Peptide F1.2

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US Patent:
58306811, Nov 3, 1998
Filed:
Dec 30, 1993
Appl. No.:
8/175482
Inventors:
Marcie J. Hursting - Durham NC
Bryan T. Butman - Walkersville NC
Jerald P. Steiner - Bahama NC
Bryant M. Moore - Bahama NC
Frederick A. Dombrose - Ventura CA
Assignee:
Akzo Nobel N.V. - Arnhem
International Classification:
G01N 3353
US Classification:
435 794
Abstract:
Monoclonal antibodies and fragments thereof, with binding specificity for an epitope on the carboxy terminus of prothrombin activation peptide F1. 2, which can be used in immunoassays to predict thrombosis by measuring the extent of activation of prothrombin. These monoclonal antibodies are also included in a kit for performing such immunoassays.
Frederick A Dombrose from Charlotte, NC, age ~79 Get Report