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Farren J Isaacs

from Stamford, CT
Age ~50
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Also known as:
Farren Hillary Isaacs, Isaacs J Farren, Isaacs Jeffrey Marion Tr, Justin Isaacs Farren, Isaac Farren
Phone and address:
72 West Ln, Stamford, CT 06905
Related to:
Rozanne Bernstein, 77Heather R Elias, 38Naithan EliasKaren Elias, 70Stanley Bernstein, 73
Connected to:
Abby M Isaacs, 45Alyson H Isaacs, 64Alyssa M Isaacs, 42Anwar A Isaacs, 38Audrey E Isaacs, 30Billy J Isaacs, 53Brenda H Isaacs, 49Cara R Isaacs, 39Cari L Isaacs, 39Catherine C Isaacs, 55

Farren Isaacs Phones & Addresses

  • 72 West Ln, Stamford, CT 06905
  • 116 Morgan St #337A, Stamford, CT 06905
  • 200 Freeman St #1 200, Brookline, MA 02446 (617) 731-8444
  • 110 Babcock St #17, Brookline, MA 02446 (617) 713-0113
  • Paradise Valley, AZ
  • 111 E Linger Ln, Phoenix, AZ 85020 (602) 997-5592
  • Sewickley, PA
  • 116 Morgan St APT 337, Stamford, CT 06905

Education

Degree: High school graduate or higher

Business Records

Name / Title
Company / Classification
Phones & Addresses
Farren J. Isaacs
Cto
ENEVOLV, INC
Commercial Physical Research Engineering Services · Nonclassifiable Establishments
83 Cambridge Pkwy, Cambridge, MA 02142
83 Cambridge Pkwy Unit W806, Cambridge, MA 02142
85 High St, Boston, MA 02129
116 Morgan St #37, Stamford, CT 06905

Publications

Us Patents

Multiplex Automated Genome Engineering

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US Patent:
8569041, Oct 29, 2013
Filed:
Mar 5, 2012
Appl. No.:
13/411712
Inventors:
George M. Church - Brookline MA, US
Harris H. Wang - Cambridge MA, US
Farren J. Isaacs - Brookline MA, US
Assignee:
President and Fellows of Harvard College - Cambridge MA
International Classification:
C12M 1/36
US Classification:
4352851, 4352861, 4352885
Abstract:
The present invention relates to automated methods of introducing multiple nucleic acid sequences into one or more target cells.

Cis/Trans Riboregulators

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US Patent:
20070136827, Jun 14, 2007
Filed:
Nov 14, 2003
Appl. No.:
10/535128
Inventors:
James Collins - Newton MA, US
Farren Isaacs - Brookline MA, US
Charles Cantor - Del Mar CA, US
Daniel Dwyer - Brookline MA, US
Assignee:
TRUSTEES OF BOSTON UNIVERSITY - Boston MA
International Classification:
A01K 67/027
C07H 21/04
C12N 15/09
C12N 5/06
US Classification:
800014000, 435325000, 435455000, 536023200
Abstract:
The present invention provides nucleic acid molecules, DNA constructs, plasmids, and methods for post-transcriptional regulation of gene expression using RNA molecules to both repress and activate translation of an open reading frame. Repression of gene expression is achieved through the presence of a regulatory nucleic acid element (the cis-repressive RNA or crRNA) within the 5′ untranslated region (5′ UTR) of an mRNA molecule. The nucleic acid element forms a hairpin (stem/loop) structure through complementary base pairing. The hairpin blocks access to the mRNA transcript by the ribosome, thereby preventing translation. In particular, in embodiments of the invention designed to operate in prokaryotic cells, the stem of the hairpin secondary structure sequesters the ribosome binding site (RBS). In embodiments of the invention designed to operate in eukaryotic cells, the stem of the hairpin is positioned upstream of the start codon, anywhere within the 5′ UTR of an mRNA. A small RNA (trans-activating RNA, or taRNA), expressed in trans, interacts with the crRNA and alters the hairpin structure. This alteration allows the ribosome to gain access to the region of the transcript upstream of the start codon, thereby activating transcription from its previously repressed state.

Multiplex Automated Genome Engineering

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US Patent:
20090317910, Dec 24, 2009
Filed:
Apr 21, 2009
Appl. No.:
12/427478
Inventors:
George M. Church - Brookline MA, US
Harris H. Wang - Cambridge MA, US
Farren J. Isaacs - Brookline MA, US
Assignee:
President and Fellows of Harvard College - Cambridge MA
International Classification:
C12N 15/00
US Classification:
435440
Abstract:
The present invention relates to automated methods of introducing multiple nucleic acid sequences into one or more target cells.

Multiplex Genome Engineering In Eukaryotes

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US Patent:
20210222155, Jul 22, 2021
Filed:
Apr 27, 2017
Appl. No.:
16/097091
Inventors:
- New Haven CT, US
Farren Isaacs - Stamford CT, US
International Classification:
C12N 15/10
Abstract:
Compositions and methods for gene editing are provided. The methods employ an oligo-based annealing mechanism that is rooted in the process of DNA replication rather than homologous recombination (HR). Oligo incorporation efficiencies are comparable and often exceed those of CRISPR/cas9 editing without the need for double strand breaks (DSBs). By relying on the multiplex annealing of oligos rather than DSBs the process is highly scalable across a genomic region of interest and can generate many scarless modifications of a chromosome simultaneously. Combinatorial genomic diversity can be generated across a population of cells in a single transformation event; genomic landscapes can be traversed through successive iterations of the process, and genome-wide changes can be massively parallelized and amplified through systematic strain mating.

Processes And Host Cells For Genome, Pathway, And Biomolecular Engineering

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US Patent:
20190309289, Oct 10, 2019
Filed:
Jun 11, 2019
Appl. No.:
16/437018
Inventors:
- Medford MA, US
James E. SPOONAMORE - Medford MA, US
Ilan E. WAPINSKI - Medford MA, US
Farren J. ISAACS - Medford MA, US
Gregory B. FOLEY - Medford MA, US
International Classification:
C12N 15/10
C12N 15/85
C12N 15/11
C12N 15/81
C12N 15/70
Abstract:
The present disclosure provides compositions and methods for genomic engineering.

Phosphopeptide-Encoding Oligonucleotide Libraries And Methods For Detecting Phosphorylation-Dependent Molecular Interactions

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US Patent:
20190256843, Aug 22, 2019
Filed:
Feb 18, 2019
Appl. No.:
16/278610
Inventors:
- New Haven CT, US
- Santa Clara CA, US
Farren Isaacs - Stamford CT, US
Jeffrey R. Sampson - San Jose CA, US
International Classification:
C12N 15/10
Abstract:
The present invention relates to libraries of phosphopeptide-encoding oligonucleotides and methods of preparing such libraries. The present invention also relates to methods of detecting, visualizing, or screening for phosphorylation-dependent protein-protein interactions using recombinant phosphopeptides and/or phosphopeptide-encoding oligonucleotides. The present invention also relates to sets or kits of oligonucleotides having regions that encode phosphopeptides.

Processes And Host Cells For Genome, Pathway, And Biomolecular Engineering

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US Patent:
20180320170, Nov 8, 2018
Filed:
Mar 1, 2018
Appl. No.:
15/909191
Inventors:
- Cambridge MA, US
James E. Spoonamore - Cambridge MA, US
Ilan N. Wapinski - Cambridge MA, US
Farren J. Isaacs - Cambridge MA, US
Gregory B. Foley - Cambridge MA, US
International Classification:
C12N 15/10
C12N 15/81
C12N 15/70
C12N 15/11
C12N 15/85
Abstract:
The present disclosure provides compositions and methods for genomic engineering.

Cis/Trans Riboregulators

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US Patent:
20180142247, May 24, 2018
Filed:
Nov 30, 2016
Appl. No.:
15/364659
Inventors:
- Boston MA, US
Farren J. Isaacs - Brookline MA, US
Charles R. Cantor - Del Mar CA, US
Daniel J. Dwyer - Brookline MA, US
Assignee:
TRUSTEES OF BOSTON UNIVERSITY - Boston MA
International Classification:
C12N 15/67
C12Q 1/6897
C12N 15/11
Abstract:
The present invention provides nucleic acid molecules, DNA constructs, plasmids, and methods for post-transcriptional regulation of gene expression using RNA molecules to both repress and activate translation of an open reading frame. Repression of gene expression is achieved through the presence of a regulatory nucleic acid element (the cis-repressive RNA or crRNA) within the 5′ untranslated region (5′ UTR) of an mRNA molecule. The nucleic acid element forms a hairpin (stem/loop) structure through complementary base pairing. The hairpin blocks access to the mRNA transcript by the ribosome, thereby preventing translation. In particular, in embodiments of the invention designed to operate in prokaryotic cells, the stem of the hairpin secondary structure sequesters the ribosome binding site (RBS). In embodiments of the invention designed to operate in eukaryotic cells, the stem of the hairpin is positioned upstream of the start codon, anywhere within the 5′ UTR of an mRNA. A small RNA (trans-activating RNA, or taRNA), expressed in trans, interacts with the crRNA and alters the hairpin structure. This alteration allows the ribosome to gain access to the region of the transcript upstream of the start codon, thereby activating transcription from its previously repressed state.
Control profile
Farren J Isaacs from Stamford, CT, age ~50 Get Report