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Eva S Engvall

from Buellton, CA
Age ~84
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Also known as:
Eva S Ruoslahti
Related to:
Harri I Ruoslahti, 63Harri I RuoslahtiErkki I Ruoslahti, 84
Connected to:
Kim M Engvall, 68Marilyn Engvall, 89Robert U Engvall, 48Brian C Engvik, 32Dorothy M Engwald, 80Clarence W Engwall, 91Jamie L Engwer, 36Debra Enholm, 69Goran E Enhorning, 100Michael Eni

Eva Engvall Phones & Addresses

  • Buellton, CA
  • 17657 Los Morros, Rancho Santa Fe, CA 92067
  • Santa Ynez, CA
  • San Diego, CA
  • Santa Barbara, CA

Work

Company: Sanford burnham prebys medical discovery institute Position: Professor emerita

Industries

Research

Resumes

Resumes

Eva Engvall Photo 1

Professor Emerita

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Location:
Rancho Santa Fe, CA
Industry:
Research
Work:
Sanford Burnham Prebys Medical Discovery Institute
Professor Emerita

Publications

Us Patents

Merosin Fragments And Uses Thereof

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US Patent:
56249055, Apr 29, 1997
Filed:
Feb 23, 1995
Appl. No.:
8/393250
Inventors:
Eva Engvall - Rancho Santa Fe CA
Ilmo Leivo - Helsinki, FI
Assignee:
La Jolla Cancer Research Foundation - La Jolla CA
International Classification:
A61K 3800
A61K 3839
G01N 33567
C07K 1478
US Classification:
514 21
Abstract:
This invention provides a purified protein, having an apparent molecular weight of about 800 kDa, designated merosin. Also provided is an isolated nucleic acid sequence which encodes merosin. The invention further provides antibodies, vectors, and the expression of recombinant proteins by use of a host vector system. The invention also provides the use of merosin to promote neurite growth and for certain diagnostic applications.

Changes In Laminin Subunit Composition Are Diagnostic Of Fukuyama Congenital Muscular Dystrophy

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US Patent:
57802440, Jul 14, 1998
Filed:
Feb 14, 1994
Appl. No.:
8/196828
Inventors:
Eva Engvall - Rancho Santa Fe CA
Kiichi Arahata - Tokyo, JP
Assignee:
La Jolla Cancer Research Foundation - La Jolla CA
International Classification:
G01N 3353
US Classification:
435 721
Abstract:
The present invention relates to a method for detecting altered expression or localization of a cytoskeleton/basal lamina protein in a tissue sample obtained from an individual, wherein the altered expression or localization are associated with a muscular dystrophy such as Fukuyama congenital muscular dystrophy (FCMD). The invention provides an immunohistochemical method for detecting the expression and localization in a tissue, such as muscle, of laminin M (merosin), which is a protein component of the basal lamina, wherein certain defined changes are diagnostic of individuals predisposed to FCMD. The invention also provides a prenatal diagnostic screening procedure, using a tissue such as placenta, wherein the screening procedure can identify an individual predisposed to FCMD. The invention further provides methods for identifying an individual predisposed to other muscular dystrophies such as Walker-Warburg Syndrome (WWS) and muscle-eye-brain disease of the Finnish type (MEB).

Adhesion Receptor For Laminin And Its Use

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US Patent:
51808099, Jan 19, 1993
Filed:
May 25, 1989
Appl. No.:
7/357354
Inventors:
Erkki I. Ruoslahti - Rancho Santa Fe CA
Eva Engvall - Rancho Santa Fe CA
Kurt R. Gehlsen - San Diego CA
Assignee:
La Jolla Cancer Research Foundation - La Jolla CA
International Classification:
C07K 1506
C07K 1514
C07K 320
C07K 1702
US Classification:
530350
Abstract:
An adhesion receptor for laminin is provided. The receptor is isolated from cell or tissue extracts and fractionated on an affinity column composed of cell attachment-promoting fragments of laminin coupled to Sepharose. TM. in the presence of divalent cations. This receptor can be used to prepare specific antibodies for the analysis of the amount of laminin receptor expressed by cells and has other applications in cellular and tumor biology.

Merosin Fragments And Uses Thereof

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US Patent:
58374965, Nov 17, 1998
Filed:
Jun 2, 1995
Appl. No.:
8/460309
Inventors:
Eva Engvall - Escondido CA
Ilmo Leivo - Helsinki, FI
Assignee:
La Jolla Cancer Research Foundation - La Jolla CA
International Classification:
C12P 2106
C07K 100
US Classification:
435 693
Abstract:
This invention provides an isolated nucleic acid molecule encoding a subunit of a protein, the protein having an apparent molecular weight of about 800 kD, designated merosin. Also provided are isolated nucleic acid molecules which encode merosin fragments. Anti-merosin antibodies, vectors for the recombinant production of merosin, and the expression of recombinant proteins by use of a host vector system also are provided. The invention further provides the use of merosin to promote neurite growth and for certain diagnostic applications.

Merosin, Nucleic Acids Encoding, Fragments And Uses Thereof

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US Patent:
54441587, Aug 22, 1995
Filed:
Jul 8, 1993
Appl. No.:
8/087642
Inventors:
Eva Engvall - Escondido CA
Joshua Sanes - St. Louis MO
Assignee:
La Jolla Cancer Research Foundation - La Jolla CA
Washington University - St. Louis MO
International Classification:
A61K 3814
A61K 3816
C07K 1478
US Classification:
530395
Abstract:
A substantially pure heterotrimeric laminin variant comprising the structure M-X-B2, wherein M is the M polypeptide of merosin; X is selected from the group consisting of the B1 chain of laminin and S-laminin; and B2 is the B2 chain of laminin.

Nucleic Acids Encoding Merosin

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US Patent:
58722319, Feb 16, 1999
Filed:
Sep 22, 1993
Appl. No.:
8/125077
Inventors:
Eva Engvall - Escondido CA
Ilmo Leivo - Helsinki, FI
Assignee:
La Jolla Cancer Research Foundation - La Jolla CA
International Classification:
C07H 2102
C07H 1900
C12P 2106
C12N 1500
US Classification:
536 231
Abstract:
This invention provides an isolated nucleic acid molecule encoding a subunit of a protein, the protein having an apparent molecular weight of about 800 kD, designated merosin. Also provided are isolated nucleic acid molecules which encode merosin fragments. Anti-merosin antibodies, vectors for the recombinant production of merosin, and the expression of recombinant proteins by use of a host vector system also are provided. The invention further provides the use of merosin to promote neurite growth and for certain diagnostic applications.

Method For The Purification Of Collagens

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US Patent:
43917496, Jul 5, 1983
Filed:
Oct 19, 1981
Appl. No.:
6/313326
Inventors:
Eva S. Engvall - Olivenhain CA
Erkki I. Ruoslahti - Olivenhain CA
Assignee:
La Jolla Cancer Research Foundation - La Jolla CA
International Classification:
A61K 3516
C07G 700
C08H 106
C09H 100
US Classification:
2601237
Abstract:
Collagen affinity matrices are prepared, useful for separating collagenous substances from other high molecular weight proteinaceous substances. Fibronectin is fragmentated chemically or by enzymatic digestion, etc. Fragments of fibronectin, which retain the collagen-binding site but are severed from other binding sites of intact fibronectin, are selected and coupled to solid support material.

Isbn (Books And Publications)

Extracellular Matrix Components

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Author

Eva Engvall

ISBN #

0121821463

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Eva Engvall Photo 2

Eva Engvall

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Eva S Engvall from Buellton, CA, age ~84 Get Report